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Chemical Structure| 51674-77-2 Chemical Structure| 51674-77-2

Structure of 51674-77-2

Chemical Structure| 51674-77-2

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Product Details of [ 51674-77-2 ]

CAS No. :51674-77-2
Formula : C7H4ClN3
M.W : 165.58
SMILES Code : ClC1=NC=NC2=CC=CN=C12
MDL No. :MFCD10566748
InChI Key :PVTHTRIHQGKZNE-UHFFFAOYSA-N
Pubchem ID :13101639

Safety of [ 51674-77-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 51674-77-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 51674-77-2 ]

[ 51674-77-2 ] Synthesis Path-Downstream   1~3

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  • [ 51674-77-2 ]
  • [ 50608-99-6 ]
  • [ 171347-62-9 ]
YieldReaction ConditionsOperation in experiment
57% With methanesulfonic acid; triethylamine; aniline; In methanol; ethanol; chloroform; acetone; 4-Anilinopyrido[3,2-d]pyrimidine mesylate. A solution of 4-chloropyrido[3,2-d]pyrimidine (84 mg, 0.5 mmol), aniline (56 mg, 0.6 mmol) and triethylamine (62 mg, 0.6 mmol) in EtOH (2 mL) are refluxed under N2 with stirring for 2 h. The crude reaction mixture is purified on a preparative tlc plate (silica), eluding once with 3% MeOH in CHCl3. The major band is extracted, and evaporated to dryness under reduced pressure, and the residual solid is dissolved in acetone, (5 mL), filtered, and methanesulfonic acid (32 muL, 0.5 mmol) is added slowly with swirling. The precipitate is collected by suction filtration, rinsed with acetone and dried in a vacuum oven to give 4-anilinopyrido[3,2-d]pyrimidine mesylate (91 mg, 57%) as dull yellow needles. 1 H NMR (DMSO) delta 11.75 (1H, slbrs), 9.11 (1H, dd, J=1.5, 4.3 Hz), 8.97 (1H, s), 8.32 (1H, dd, J=1.5, 8.4 Hz), 8.12 (1H, dd, J=4.3, 8.5 Hz), 7.88 (2H, d, J=8.2 Hz), 7.49 (2E, t, J=8.0 Hz), 7.32 (1H, t, J=7.0 Hz), 2.34 (3H, s).
 

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