Alternatived Products of [ 51407-46-6 ]
Product Details of [ 51407-46-6 ]
CAS No. : | 51407-46-6 |
MDL No. : | MFCD01940896 |
Formula : |
C13H18O
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
190.28
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Pubchem ID : | - |
Synonyms : |
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Application In Synthesis of [ 51407-46-6 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 51407-46-6 ]
- 1
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[ 51407-46-6 ]
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[ 38861-78-8 ]
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[ 15687-27-1 ]
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[ 40150-92-3 ]
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[ 105899-75-0 ]
Yield | Reaction Conditions | Operation in experiment |
1: 85 % Chromat.
2: 7 % Chromat.
3: 2 % Chromat.
4: 1 % Chromat. |
With oxygen; manganese(II) stearate; 3-chloro-benzenecarboperoxoic acid In decane at 0℃; for 2h; other reagents and solvents, var. temperature, var. pressures; |
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- 2
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[ 36039-36-8 ]
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[ 51407-46-6 ]
Yield | Reaction Conditions | Operation in experiment |
91% |
With Dess-Martin periodane In dichloromethane Inert atmosphere; |
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80% |
With oxalyl dichloride; dimethyl sulfoxide; triethylamine In dichloromethane at -78℃; |
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74% |
With Dess-Martin periodane In dichloromethane at 20℃; for 1h; Inert atmosphere; |
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54% |
With oxalyl dichloride; dimethyl sulfoxide In dichloromethane at -78℃; for 1h; |
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With oxalyl dichloride; dimethyl sulfoxide; triethylamine 1) -65 deg C, CH2Cl2, 5 min; Multistep reaction; |
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327 mg |
With pyridinium chlorochromate In dichloromethane for 1.5h; Inert atmosphere; Schlenk technique; |
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Reference:
[1]Friest, Jacob A.; Maezato, Yukari; Broussy, Sylvain; Blum, Paul; Berkowitz, David B.
[Journal of the American Chemical Society, 2010, vol. 132, # 17, p. 5930 - 5931]
[2]Galletti, Paola; Emer, Enrico; Gucciardo, Gabriele; Quintavalla, Arianna; Pori, Matteo; Giacomini, Daria
[Organic and Biomolecular Chemistry, 2010, vol. 8, # 18, p. 4117 - 4123]
[3]Tassano, Erika; Faber, Kurt; Hall, Mélanie
[Advanced Synthesis and Catalysis, 2018, vol. 360, # 14, p. 2742 - 2751]
[4]Neibecker, Denis; Reau, Regis; Lecolier, Serge
[Journal of Organic Chemistry, 1989, vol. 54, # 22, p. 5208 - 5210]
[5]Chiarino; Ferrario; Pellacini; Sala
[Journal of Heterocyclic Chemistry, 1989, vol. 26, # 3, p. 589 - 593]
[6]Huang, Huan-Ming; Bellotti, Peter; Erchinger, Johannes E.; Paulisch, Tiffany O.; Glorius, Frank
[Journal of the American Chemical Society, 2022, vol. 144, # 4, p. 1899 - 1909]
- 3
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[ 51407-46-6 ]
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[ 51146-56-6 ]
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[ 51146-57-7 ]
- 4
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[ 41283-72-1 ]
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[ 51407-46-6 ]
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[ 36039-36-8 ]
Yield | Reaction Conditions | Operation in experiment |
1: 65%
2: 15% |
With diisobutylaluminium hydride In diethyl ether; hexane at -78℃; |
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1: 65%
2: 15% |
With diisobutylaluminium hydride In diethyl ether; hexane at -78℃; |
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Reference:
[1]Giacomini, Daria; Galletti, Paola; Quintavalla, Arianna; Gucciardo, Gabriele; Paradisi, Francesca
[Chemical Communications, 2007, # 39, p. 4038 - 4040]
[2]Galletti, Paola; Emer, Enrico; Gucciardo, Gabriele; Quintavalla, Arianna; Pori, Matteo; Giacomini, Daria
[Organic and Biomolecular Chemistry, 2010, vol. 8, # 18, p. 4117 - 4123]
- 5
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[ 51523-49-0 ]
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[ 51407-46-6 ]
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[ 60601-66-3 ]
Yield | Reaction Conditions | Operation in experiment |
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In ethanol |
1 EXAMPLE 1
EXAMPLE 1 α-(4-Isobutylphenyl)propionaldehyde (8.6 g., 0.045 mole) and 8.4 g. (0.045 mole) of 2-cyclohexylmethylpiperidine were dissolved in 200 ml. of absolute ethanol in a Parr hydro-generator and the mixture reduced with hydrogen over 703 mg. of palladium-on-charcoal. Reduction was complete in about 15 hours, and the mixture was filtered and the filtrate evaporated to dryness to give 16.3 g. of crude product which was chromatographed on 300 g. of alumina using 10% ether/90% hexane as eluent. There was thus obtained 10.0 g. of 2-cyclohexylmethyl-1-[2-(4-isobutylphenyl)propyl]piperidine as a colorless oil. The hydrochloride salt melts at 132° - 160°C. |
- 6
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[ 36039-36-8 ]
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[ 38861-78-8 ]
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[ 51407-46-6 ]
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[ 15687-27-1 ]
Yield | Reaction Conditions | Operation in experiment |
1: 15%
2: 15%
3: 44% |
With sodium tungstate; dihydrogen peroxide; tetra(n-butyl)ammonium hydrogensulfate at 90℃; |
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- 7
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[ 51407-46-6 ]
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[ 51146-56-6 ]
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[ 51146-57-7 ]
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[ 114937-30-3 ]
- 8
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[ 623-53-0 ]
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[ 38861-78-8 ]
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[ 51407-46-6 ]
- 9
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[ 51407-46-6 ]
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[ 64758-90-3 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1: diethyl ether / 3 h / 0 - 20 °C / Inert atmosphere
2: pyridinium chlorochromate; mesoporous silica / dichloromethane / 3 h / 20 °C / Inert atmosphere |
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