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Chemical Structure| 51323-71-8 Chemical Structure| 51323-71-8

Structure of Dodecyl methane sulfonate
CAS No.: 51323-71-8

Chemical Structure| 51323-71-8

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Product Details of [ 51323-71-8 ]

CAS No. :51323-71-8
Formula : C13H28O3S
M.W : 264.42
SMILES Code : CS(=O)(OCCCCCCCCCCCC)=O

Safety of [ 51323-71-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H303-H315-H317-H318-H335-H413
Precautionary Statements:P261-P264-P271-P272-P273-P280-P302+P352-P304+P340+P312-P305+P351+P338+P310-P312-P333+P313-P403+P233-P405-P501

Application In Synthesis of [ 51323-71-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 51323-71-8 ]

[ 51323-71-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 51323-71-8 ]
  • [ 623-57-4 ]
  • [ 848982-36-5 ]
YieldReaction ConditionsOperation in experiment
67% General procedure: Sodium hydride (38.6 mmol, 1.54 g, 60percent in oil) was charged in a 250 mL two-neck RB flask under nitrogen atmosphere and anhydrous THF (20 mL) was added to remove oil. The resulting suspension was stirred for 10 minutes and then the stirring was stopped to settle the sodium hydride solids. The supernatant liquid was removed with syringe and a fresh THF (100 mL) was added. To this slurry, a solution of 3-(dimethylamino)-propane-1,2-diol (14.9 mmol, 1.77 g) in THF (15 mL) was added dropwise for 10 minutes at RT. The resulting suspension was heated to reflux for 24 h. Then, a solution of methanesulfonic acid dodecyl ester (38.6 mmol, 10.2 g) in THF (22 mL) was added and again the mixture was heated to reflux for 5 days. Then, it was cooled to RT and the mixture was filtered through a 3-cm plug of celite while washing with ethyl acetate (1.0 L). The filtrate was removed under vacuum and the residue was partitioned between diethyl ether (250 mL) and 0.2M aqueous sodium hydroxide solution (250 mL). The two layers were separated and the organic layer was washed with water (200 mL), brine solution (200 mL), and dried over anhydrous magnesium sulfate. Filtration and concentration gave the light brown oil (7.93 g) which was purified using an ISCO (150 g) flash column chromatography to obtain 4.51 g (67percent yield) of (rac)-2,3-bis(dodecyloxy-propyl)-N,N-dimethyl-amine as a light yellow oil. ES(+)-HRMS m/e calcd. for C29H61NO2 (M+H)+ 456.4775, obsd. 456.4785.
 

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