There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
Structure of 50533-97-6
*Storage: {[sel_prStorage]}
*Shipping: {[sel_prShipping]}
The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
4.5
*For Research Use Only !
Change View
Size | Price | VIP Price | US Stock |
Global Stock |
In Stock | ||
{[ item.pr_size ]} |
Inquiry
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.discount_usd) ]} {[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} |
Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]} | Inquiry {[ item.pr_usastock ]} In Stock Inquiry - | {[ item.pr_chinastock ]} {[ item.pr_remark ]} In Stock 1-2 weeks - Inquiry - | Login | - + | Inquiry |
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days
1-2weeks
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price, item.pr_usd) ]}
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
In Stock
- +
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 50533-97-6 |
Formula : | C7H16N2 |
M.W : | 128.22 |
SMILES Code : | CN(C)C1CCNCC1 |
MDL No. : | MFCD00023144 |
InChI Key : | YFJAIURZMRJPDB-UHFFFAOYSA-N |
Pubchem ID : | 417391 |
GHS Pictogram: |
![]() |
Signal Word: | Danger |
Hazard Statements: | H314 |
Precautionary Statements: | P264-P271-P280-P301+P330+P331-P304+P340-P303+P361+P353-P305+P351+P338-P310-P363-P403+P233-P501 |
Class: | 8 |
UN#: | 2735 |
Packing Group: | Ⅲ |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With ammonium hydroxide; triethylamine; In N-methyl-acetamide; methanol; chloroform; water; | 5.3. (S)-5-(8-amino-7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-3-[1-[5-[4-(dimethyl_amino)piperidin-1-yl]-5-oxopentyl]pyrrolidin-3-yl]-1,3,4-oxadiazol-2-(3H)-one 0.24 g (0.51 mmol) of (S)-3-[5-[7-chloro-8-amino-2,3-dihydro-1,4-benzodioxin-5-yl]2-oxo-2,3-dihydro-1,3,4-oxadiazol-3-yl]pyrrolidine-1-pentanoic acid dissolved in 2.5 ml of dimethylformamide, and 0.14 ml (1.01 mmol) of triethylamine are introduced into a 25 ml three-necked round-bottomed flask. A solution of 0.16 g (1.01 mmol) of 1,1'-carbonylbis-1H-imidazole in 1.1 ml of dimethylformamide is added dropwise and the mixture is stirred at room temperature for 2 h 30 min. A solution of 0.76 mmol of 4-(dimethylamino)piperidine in 1.8 ml of dimethylformamide (prepared beforehand by heating a suspension of 0.16 g (0.76 mmol) of <strong>[4876-59-9]4-(dimethylamino)piperidine dihydrochloride</strong> in 1.8 ml of dimethylformamide and 0.28 ml (2.02 mmol) of triethylamine at 60 C. for 2 h) is added and the mixture is stirred at room temperature for 18 h. The reaction medium is poured into 30 ml of water and extracted with chloroform. The product is purified by chromatography on silica gel, eluding with a 95/5/0.5 and then 80/20/2 mixture of chloroform, methanol and aqueous ammonia. 0.08 g of product is thus obtained in the form of a sticky paste. [alpha]20D =+26 (c=0.4, CHCl3). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With N-ethyl-N,N-diisopropylamine; In ISOPROPYLAMIDE; at 100℃; for 4h; | 4-(Dimethylamino)piperidine (2.89 g) was added to a stirred solution of 2-ethoxy-4-fluoro- 1 -nitrobenzene (3.79 g) and DIPEA (7.1 mL) in DMA (17.5 mL). The mixture was then heated to 1000C for 4h. The mixture was then concentrated in vacuo and purified by SCX, eluting with 7M NH3/ MeOH to afford the title compound (6.10 g, 102 %) as a yellow solid; 1H NMR: 1.39 (5H, m), 1.82 (2H, d), 2.19 (6H, s), 2.36 (IH, m), 2.96 (2H, t), 4.00 (2H, d), 4.19 (2H, q), 6.50 (IH, dd), 6.58 (IH, d), 7.86 (IH, d); m/z: MH+ 294. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Example 102 (method 2) (Synthetic Intermediate)(2-Bromo-pyridin-4-yl)-[5-(4-dimethylamino-piperidin-1-yl)-1-(2-trimethylsilanyl- ethoxymethyl)-1 H-benzoimidazol-2-yl]-methanone (as a mixture with the 6- regioisomer). Starting with Example 25, Step 1 was performed by following procedures describe for Example 42. Step 2 and Step 3 were performed by following procedures describe for Example 48. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Example 102 (method 2) (Synthetic Intermediate)(2-Bromo-pyridin-4-yl)-[5-(4-dimethylamino-piperidin-1-yl)-1-(2-trimethylsilanyl- ethoxymethyl)-1 H-benzoimidazol-2-yl]-methanone (as a mixture with the 6- regioisomer). Starting with Example 25, Step 1 was performed by following procedures describe for Example 42. Step 2 and Step 3 were performed by following procedures describe for Example 48. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
81% | With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20℃; | 4-Bromopicolinaldehyde (300 mg, 1 .61 mmol) was dissolved in dichloroethane (30 mL). N,N-Dimethylpiperidin-4-amine (227 mg, 1.77 mmol) and sodium triacetoxyborohydride (1.025 g, 4.84 mmol) were added and the mixture was stirred at room temperature overnight. The mixture was partitioned between water and ethylacetate. The aqueous phase was basified to pH=10 with a diluted sodium hydroxide solution. The aqueous phase was then extracted with dichloromethane. The combined organics were dried over anhydrous magnesium sulphate, filtered and evaporated under reduced pressure to give 390 mg (81percent yield) of the title compound as an orange oil.LRMS (M+1): 298, 3001H NMR (400 MHz, Chloroform-d)oe ppm 1.59 (qd, J = 12.2, 3.8 Hz, 3H), 1.73?1.86(m, 2H), 2.02 ? 2.23 (m, 3H), 2.29 (s, 7H), 2.92 (d, J = 11.9 Hz, 2H), 3.61 (s, 2H), 7.33(dd, J = 5.3, 1.9 Hz, 1 H), 7.63 (d, J = 1.5 Hz, 1 H), 8.35 (d, J = 5.3 Hz, 1 H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
0.73 g | With potassium carbonate; In acetonitrile; | Add N,N-dimethylacridin-4-amine (0.586g) with K2CO3 (1.160 g) to a solution of <strong>[168173-56-6]2-bromo-5-(chloromethyl)pyridine</strong> (0.853 g) in acetonitrile (10 mL). Add water (30mL), extracted with EA (50 mL×3), the combined organic layers were dried with EtOAc, 730 g of 1-((6-bromopyridin-3-yl)methyl)-N,N-dimethylpiperidin-4-amine were obtained. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75% | tert-butyl (4-formyl-1 ,3-thiazol-2-yl)carbamate (200 mg, 0.88 mmol) in DMA (3 mL) was treated with N,N- dimethylpiperidin-4-amine (0.155 mL, 1.3 mmol) and stirred at rt over 1 h. AcOH (0.025 mL, 0.43 mmol) and sodium triacetoxyborohydride (465 mg, 2.19 mmol) were added to the reaction and stirred at rt for 20 h. The residue was partitioned between EtOAc and saturated aqueous NaHC03. The organic layer was dried over Na2S04 and evaporated to dryness. The crude was purified by column chromatography over silica gel (DCM:7N NH3 in MeOH = 9:1) to give the title compound as colourless oil (225 mg, 75%).1H NMR (500 MHz, DMSO-de) delta ppm 1.27 - 1.38 (m, 2 H) 1.47 (s, 9 H) 1.61 - 1.75 (m, 2 H) 1.87 - 2.03 (m, 3 H) 2.13 (s, 6 H) 2.78 - 2.89 (m, 2 H) 3.37 (s, 2 H) 6.85 (s, 1 H).HRMS (ESI+): calcd. for C16H29N4O2S [M + H]+341.2006; found 341.2008. |
A175565 [76272-56-5]
endo-3-Amine-9-methyl-9-azabicyclo[3,3,1]nonane
Similarity: 1.00
A375069 [73579-08-5]
1-Methyl-4-(methylamino)piperidine
Similarity: 1.00
A119999 [172281-90-2]
N,N-Dimethylpiperidin-4-amine hydrochloride
Similarity: 0.95
A125383 [4876-59-9]
4-(Dimethylamino)piperidine dihydrochloride
Similarity: 0.95
A375069 [73579-08-5]
1-Methyl-4-(methylamino)piperidine
Similarity: 1.00
A125383 [4876-59-9]
4-(Dimethylamino)piperidine dihydrochloride
Similarity: 0.95