503309-10-2|(2-Fluoro-4-(trifluoromethoxy)phenyl)boronic acid| Ambeed

Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

{[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

Quality Control of [ 503309-10-2 ] Purity: 98% SDS Specification

COA

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

NMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

CNMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

HPLC

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

LC-MS

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

1-2 Day Shipping
High Quality
Technical Support

Product Details of [ 503309-10-2 ]

CAS No. :	503309-10-2
Formula :	C₇H₅BF₄O₃
M.W :	223.92
SMILES Code :	FC(F)(F)OC1=CC=C(B(O)O)C(F)=C1
MDL No. :	MFCD11040275
InChI Key :	YQMMVZVQAHYXFZ-UHFFFAOYSA-N
Pubchem ID :	22065121

Safety of [ 503309-10-2 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 503309-10-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 503309-10-2 ]

[ 503309-10-2 ] Synthesis Path-Downstream 1~35

1
[ 168971-68-4 ]
[ 5419-55-6 ]
[ 503309-10-2 ]

Yield	Reaction Conditions	Operation in experiment
41%	With hydrogenchloride; n-butyllithium; In tetrahydrofuran;	Example I 2-Fluoro-4-trifluoromethoxybenzeneboronic Acid To a solution of n-butyllithium (2.5 M solution in hexanes, 14.1 mL) in THF (30 mL) at -98 C. was added a solution of 4-bromo-3-fluorotrifluoromethoxy-benzene in THF (3 mL). After stirring for 10 min. at -98 C., triisopropyl borate (4.88 mL, 3.98 g, 21 mmol) was added at a rate needed to keep the temperature below -97 C. The reaction mixture was allowed to warm to -30 C. over 30 minutes, re-cooled to -78 C. and stirred at this temperature for 30 min. Concentrated hydrochloric acid (2 mL) was added and the reaction mixture was concentrated under reduced pressure. Dilute hydrochloric acid (0.2 N, 15 mL) was added and the mixture was extracted with ether (320 mL). The combined ethereal layers were extracted with dilute sodium hydroxide (0.02 N, 330 mL). The combined aqueous extracts were cooled to 0 C., acidified to pH 3.5 using concentrated hydrochloric acid and extracted with ether (3*30 mL). The combined ethereal layers were then washed with water (15 mL) and brine (15 mL), dried over magnesium sulphate and concentrated under reduced pressure to leave 2.3 g of yellow solid. Recrystallisation from hexane afforded pink needles (1.25 g, 41%): mp 89-93 C.; 1H NMR (CDCl3) δ 7.89 (t, 1H), 7.07 (d, 1H), 6.94 (d, 1H), 5.11 (d, 2H); EI/MS 223 m/e (M-1).
43 g	With n-butyllithium; In tetrahydrofuran; toluene; at -78 - -70℃; for 4h;	Tripropan-2-yl borate (43.6 g, 232 mmol) was added to a solution of 4-bromo-3-fluorophenyl trifluoromethyl ether (50.0 g, 193 mmol) in toluene (400 mL) and tetrahydrofuran (100 mL), and the mixture was cooled to -78 C. n-Butyllithium (2.5 M solution; 92.7 mL, 232 mmol) was then added drop-wise, at a rate that maintained the reaction temperature below -60 C., and the reaction mixture was stirred at -70 C. for 4 hours. After the reaction mixture had been warmed to -20 C., it was quenched via addition of aqueous hydrochloric acid (2 M, 200 mL), and then stirred at room temperature (20 C.) for 40 minutes. The aqueous layer was extracted with ethyl acetate (3×50 mL), and the combined organic layers were washed with saturated aqueous sodium chloride solution (100 mL), dried over sodium sulfate, filtered, and concentrated in vacuo to afford the product (43 g) as a white solid, which was carried directly to the next step.

References: [1]Patent: US2003/134748,2003,A1 .
[2]Patent: US2016/222007,2016,A1 .Location in patent: Paragraph 0330; 0331.

2
[ 503309-10-2 ]
[ 1095989-19-7 ]
(5R)-3-[2'-fluoro-4'-(trifluoromethoxy)biphenyl-4-yl]methyl}-5-methyl-1,3-oxazolidin-2-one [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,p. 2524 - 2529.

3
[ 503309-10-2 ]
[ 1095989-26-6 ]
[ 1160658-03-6 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,p. 2524 - 2529.

4
[ 168971-68-4 ]
[ 503309-10-2 ]

References: [1]Journal of Medicinal Chemistry,2010,vol. 53,p. 8421 - 8439.

5
[ 503309-10-2 ]
[ 1228275-57-7 ]