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Chemical Structure| 495382-05-3 Chemical Structure| 495382-05-3

Structure of 495382-05-3

Chemical Structure| 495382-05-3

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Product Details of [ 495382-05-3 ]

CAS No. :495382-05-3
Formula : C8H8BrNOS
M.W : 246.12
SMILES Code : O=C(C1=CC=C(Br)S1)NC2CC2
MDL No. :MFCD03071662

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Application In Synthesis of [ 495382-05-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 495382-05-3 ]

[ 495382-05-3 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 495382-05-3 ]
  • [ 68175-07-5 ]
  • [ 1195774-61-8 ]
YieldReaction ConditionsOperation in experiment
2.5% With caesium carbonate;copper(I) oxide; 4,7-dimethoxy-1,10-phenanthroline; In dimethyl sulfoxide; at 110 - 115℃; for 24h; Charged imidazopyridines (XI or XII) (5.115 mmoles), 2-bromo-thiophene-2-carboxamide (VIII) (3.938 mmoles), cesium carbonate (7.161 mmoles), cuprous oxide (0.307 mmoles), 4,7-dimethoxy-l,10-phenathroline (0.716 mmoles), PEG (5.1 15 mmoles) and DMSO to the RB flask fitted with thermo well and condenser. The reaction mass was heated to 110- <n="42"/>1 15 C under magnetic stirring for 24 hours. After completion, it was cooled to room temperature, dichloromethane (500 ml) added and filtered through a celite bed, washed the bed with dichloromethane (100 ml X 2), distilled off the solvent completely under reduced pressure. Aq. ammonia (10 ml) was added and extracted with ethyl acetate (250 ml X 3). Dry the ethyl acetate layer with sodium sulfate, distilled completely to get the crude compound. The crude compound is then purified by using silica gel 60-120 mesh column chromatography and DCM: MeOH 100-5 percent as mobile phase and further by preparative HPLC method to get the pure compounds (XIII, XIV).
  • 2
  • [ 2851-13-0 ]
  • [ 495382-05-3 ]
  • [ 1314090-87-3 ]
  • 3
  • [ 495382-05-3 ]
  • [ 20223-87-4 ]
  • [ 1314091-26-3 ]
 

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