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Chemical Structure| 491615-37-3 Chemical Structure| 491615-37-3

Structure of 491615-37-3

Chemical Structure| 491615-37-3

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Product Details of [ 491615-37-3 ]

CAS No. :491615-37-3
Formula : C13H13N3O
M.W : 227.26
SMILES Code : O=C(NCC1=CC=CN=C1)C2=CC=C(N)C=C2
MDL No. :MFCD02223637

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Application In Synthesis of [ 491615-37-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 491615-37-3 ]

[ 491615-37-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 491615-37-3 ]
  • [ 1030626-87-9 ]
  • [ 1030626-90-4 ]
YieldReaction ConditionsOperation in experiment
With 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; sodium t-butanolate;tris-(dibenzylideneacetone)dipalladium(0); In 1,4-dioxane; at 110℃; for 0.516667h;Microwave irradiation; A.8 4-(5-Chloro-[l,2, 4]triazolo[l, 5-a]pyridin-8-ylamino)-N-pyridin-3-ylmethyl-benzamide[0335] A solution of 8-bromo-5-chloro-[l,2,4]triazolo[l,5-a]pyridine (100 mg, 0.43 mmol), 4-Amino-N-pyridin-3-ylmethyl-benzamide (108 mg, 0.48 mmol), sodium-tert-butoxide (58 mg, 0.6 mmol), tris(dibenzylideneacetone)dipalladium (0) (39 mg, 40 mumol) and Xantphos (50 mg, 90 mumol) in dioxane is degassed for one minute by nitrogen bubbling and then irradiated in a sealed tube in a microwave (CEM Explorer) under a nitrogen atmosphere for 30 minutes at 110 0C. The solvent is evaporated and the crude is dissolved in dichloromethane and filtered in order to remove the palladium <n="73"/>catalyst. The residue is purified by flash chromatography (silica gel, dichloromethane/7N NH3 in methanol 95:5) affording the title compound (117 mg) as a solid.
 

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