4815-30-9|Diethyl 2-amino-4-methylthiophene-3,5-dicarboxylate| Ambeed

CAS No. :	4815-30-9
Formula :	C₁₁H₁₅NO₄S
M.W :	257.31
SMILES Code :	CCOC(=O)C1=C(C)C(C(=O)OCC)=C(N)S1
MDL No. :	MFCD00005450
InChI Key :	DGVXLHAJVRRLGV-UHFFFAOYSA-N
Pubchem ID :	78537

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319
Precautionary Statements:	P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Yield	Reaction Conditions	Operation in experiment
		Production Example 1 Ethyl 5-methyl-4-oxo-2-(thiophen-3-ylmethyl)-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylate 515 Milligrams of diethyl 5-amino-3-methylthiophene-2,4-dicarboxylate and 296 mg of 3-thiopheneacetonitrile were added to 8 mL of 4N hydrogen chloride-dioxane solution and stirred for 10 hours. Thereafter the liquid reaction mixture was poured on ice, and its pH was adjusted to 8 - 9 with 25% aqueous ammonia. Whereupon precipitated crystals were recovered by filtration and washed first with water, and then with hexane. The crude crystals were recrystallized from a liquid mixture of N,N-dimethylformamide and cyclohexane, to provide 397 mg of the title compound. 1H-NMR(DMSO-d6) δ: 1.30(3H,t,J=7, 1Hz),2.81(3H,s), 3.97(2H,s),4.30(2H,q,J=7.1Hz),7.0-7.6(3H,m),12.74(1H,br s) MS(m/z):334(M+)
	With hydrogenchloride; In 1,4-dioxane; cyclohexane; N,N-dimethyl-formamide;	1-a : Synthesis of ethyl 5-methyl-4-oxo-2-(thiophen-3-ylmethyl)-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylate To 8 mL of 4N hydrogen chloride in dioxane solution, 515 mg of diethyl 5-amino-3-methylthiophene-2,4-dicarboxylate and 296 mg of 3-thiopheneacetonitrile were added, and stirred for 10 hours. Thereafter the liquid reaction mixture was poured on ice, and its pH was adjusted to 8-9 with 25% aqueous ammonia. Whereupon precipitated crystals were recovered by filtration and washed with water and hexane, by the order stated. The crude crystals were recrystallized from a liquid mixture of N,N-dimethylformamide and cyclohexane, to provide 397 mg of the title compound. 1H-NMR(DMSO-d6)δ:1.30(3H,t,J=7.1Hz),2.81(3H,s),3.97(2H,s), 4.30(2H,q,J=7.1Hz),7.0-7.6(3H,m),12.74(1H,br s) MS(m/z):334(M+)

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Response
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P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
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P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
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P370 + P378	In case of fire:
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Disposal
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P501	Dispose of contents/container to ...
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Diethyl 2-amino-4-methylthiophene-3,5-dicarboxylate

CAS No.: 4815-30-9

Alternative Products

Product Details of [ 4815-30-9 ]

Safety of [ 4815-30-9 ]

Application In Synthesis of [ 4815-30-9 ]

[ 4815-30-9 ] Synthesis Path-Downstream 1~1

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed