*Storage:
*Shipping:
4.5
*For Research Use Only !
Change View
Size | Price | US Stock | Global Stock | In Stock |
100mg | łÍî¶ÊÊ | Inquiry | Inquiry | |
250mg | łòǶÊÊ | Inquiry | Inquiry | |
1g | łËÍǶÊÊ | Inquiry | Inquiry |
US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks
łÍî¶ÊÊ
łòǶÊÊ
łËÍǶÊÊ
In Stock
- +
US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 478148-60-6 |
Formula : | C8H7NO2 |
M.W : | 149.15 |
SMILES Code : | OCC1=CC2=C(OC=C2)C=N1 |
MDL No. : | MFCD11109707 |
InChI Key : | UUKNFBHTKFKPEH-UHFFFAOYSA-N |
Pubchem ID : | 22047174 |
GHS Pictogram: | ![]() |
Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Num. heavy atoms | 11 |
Num. arom. heavy atoms | 9 |
Fraction Csp3 | 0.12 |
Num. rotatable bonds | 1 |
Num. H-bond acceptors | 3.0 |
Num. H-bond donors | 1.0 |
Molar Refractivity | 40.14 |
TPSA ? Topological Polar Surface Area: Calculated from | 46.26 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from | 1.66 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by | 0.4 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from | 1.17 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from | -0.24 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by | 1.74 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions | 0.95 |
Log S (ESOL):? ESOL: Topological method implemented from | -1.56 |
Solubility | 4.14 mg/ml ; 0.0278 mol/l |
Class? Solubility class: Log S scale | Very soluble |
Log S (Ali)? Ali: Topological method implemented from | -0.94 |
Solubility | 17.2 mg/ml ; 0.115 mol/l |
Class? Solubility class: Log S scale | Very soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by | -2.72 |
Solubility | 0.282 mg/ml ; 0.00189 mol/l |
Class? Solubility class: Log S scale | Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg | High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg | Yes |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) | No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) | Yes |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) | No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) | No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) | No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) | No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from | -6.93 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from | 0.0 |
Ghose? Ghose filter: implemented from | None |
Veber? Veber (GSK) filter: implemented from | 0.0 |
Egan? Egan (Pharmacia) filter: implemented from | 0.0 |
Muegge? Muegge (Bayer) filter: implemented from | 1.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat | 0.55 |
PAINS? Pan Assay Interference Structures: implemented from | 0.0 alert |
Brenk? Structural Alert: implemented from | 0.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from | No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) | 2.25 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | With sodium hydroxide In methanol; water | C14 (770 mg, 3.48 mmol) is dissolved in 10 mL MeOH. 2N NaOH (3 mL, 6 mmol) is added, and the reaction is stirred for 1.5 h at rt. The solution is concentrated in vacuo to a residue. Water (20 mL) is added to the residue and extracted with 4*10 mL CH2Cl2. The combined organic layer is dried over K2CO3, filtered, and then concentrated in vacuo to afford furo[2,3-c]pyridin-5-yl methanol (C16) as a white solid (90percent yield). Analysis calculated for C8H7NO2: C, 64.42; H, 4.73; N, 9.39. Found: C, 64.60; H. 4.56; N, 9.44. |
90% | With sodium hydroxide In methanol; water at 20℃; for 1.5 h; | C6 (770 mg, 3.48 mmol) is dissolved in 10 mL MEOH. 2N NAOH (3 mL, 6 mmol) is added, and the reaction is stirred for 1.5 h at rt. The solution is concentrated in vacuo to a residue. Water (20 mL) is added to the residue and extracted with 4 x 10 mL CH2C12. The combined organic layer is dried (K2CO3), filtered, and then concentrated in vacuo to afford furo [2,3-c] PYRIDIN-5-YL methanol (2 AS A WHITE SOLID (90percent yield). Analysis calculated for CSH7NO2 : C, 64.42 ; H, 4.73 ; N, 9.39. Found: C, 64.60 ; H, 4.56 ; N, 9.44. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75% | With hydrogenchloride; zinc In ethanol; water at 70℃; for 1 h; Heating / reflux | C4 (32.0 g, 174 mmol) is combined with zinc powder (34.2 g, 523 mmol) in absolute EtOH (900 mL), using an overhead stirrer. The mixture is heated to 70°C, HC1 (87.2 mL, 1.05 mol) is added slowly drop-wise, and the mixture is heated to reflux for 1 h. The mixture is cooled slightly, filtered to remove the metallic zinc and concentrated to near-dryness. The yellow oil is diluted with H20 (150 mL) and EtOAc (950 mL) and is treated slowly drop-wise with 20percent Na2C03 (310 mL) as the mixture is warmed to reflux. The vigorously stirred (using overhead stirrer) mixture is refluxed for 1 h, cooled slightly and the organics removed via cannula under reduced pressure. Additional EtOAc (600 mL) is added, the mixture is heated to reflux for 1 h, cooled slightly and the organics removed as above. More EtOAc (600 mL) is added, the mixture is stirred at rt overnight then heated to reflux for 1 h, cooled slightly and most of the organics removed as above. The remaining mixture is filtered through celite, rinsed with EtOAc until no additional product elutes, and the layers separated. The aqueous layer is further extracted with EtOAc (2 X 400 mL). The combined organics are dried (MGS04) and concentrated to a dark yellow solid (23.6 g). The crude material is chromatographed over 900 g slurry-packed silica gel, eluting with 60percent EtOAc/hexane (3 L), 70percent EtOAc/hexane (2 L), and finally 100percent EtOAc. The appropriate fractions are combined and concentrated in vacuo to'afford C7 (19.5 g, 75percent) as a white solid. Anal. Calcd for CgH7NO2 : C, 64.42 ; H, 4.73 ; N, 9. 39 ; Found: C, 64.60 ; H, 4.56 ; N, 9.44. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | at 20℃; | a-8) Preparation of furo[2,3-c]pyridin-5-yl methanol Furo[2,3-c]pyridin-5-yl methyl acetate (722 mg, 3.78 mmol) was dissolved in methanol (19 mL), added potassium carbonate (1.04 g, 7.56 mmol) at room temperature, and the mixture was stirred at room temperature overnight. The reaction solution was added 1N-aqueous solution of hydrochloric acid under ice-cold conditions, and extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate, and concentrated in vacuo. The obtained residue was purified by silica-gel column chromatography (hexane/ethyl acetate), and the title compound (521 mg (yield 92percent)) was obtained as a yellow oil. 1H-NMR (CDCl3) δ: 3.68 (1H, s), 4.85 (2H, s), 6.79 (1H, s), 7.54 (1H, s), 7.79 (1H, s), 8.83 (1H, s). |
70% | With sodium hydroxide In 1,4-dioxane; water | (d) Furo[2,3-c]pyridin-5-ylmethanol A solution of furo[2,3-c]pyridin-5-ylmethyl acetate (1.15 g) in 1,4-dioxane (30 ml) and water (10 ml) was treated with 2M sodium hydroxide (12 ml) then stirred at ambient temperature for 18hrs. The mixture was then partitioned between ethyl acetate and water. The organics were separated and dried then evaporated to dryness. This gave an oil (0.63 g, 70percent). MS (+ve ion electrospray) m/z 150 (MH+). |
70% | With sodium hydroxide; water In 1,4-dioxane at 20℃; for 18 h; | (d) Furo[2,3-c]pyridin-5-ylmethanol A solution of furo[2,3-c]pyridin-5-ylmethyl acetate (1.15 g) in 1,4-dioxane (30 ml) and water (10 ml) was treated with 2M sodium hydroxide (12 ml) then stirred at ambient temperature for 18 hrs. The mixture was then partitioned between ethyl acetate and water. The organics were separated and dried then evaporated to dryness. This gave an oil (0.63 g, 70percent). MS (+ve ion electrospray) m/z 150 (MH+). |
70% | With sodium hydroxide; water In 1,4-dioxane at 20℃; for 18 h; | (d) Furo[2,3-c]pyridin-5-ylmethanol; A solution of furo[2,3-clpyridin-5-ylmethyl acetate (1.15 g) in 1 ,4-dioxane(30 ml) and water (10 ml) was treated with 2M sodium hydroxide (12 ml) then stirred at ambient temperature for 18h. The mixture was then partitioned between <n="35"/>ethyl acetate and water. The organic fractions were separated and dried then evaporated to dryness. This gave an oil (0.63 g, 70percent).MS (+ve ion electrospray) m/z 150 (MH+). |
70% | With sodium hydroxide; water In 1,4-dioxane at 20℃; for 18 h; | (d) Furo[2,3-c]pyridin-5-ylmethanol; A solution of furo[2,3-c]pyridin-5-ylmethyl acetate (1.15 g) in 1,4-dioxane (30ml) and water (10ml) was treated with 2M sodium hydroxide (12ml) then stirred at ambient temperature for 18h. The mixture was then partitioned between ethyl acetate and water. The organic fractions were separated and dried then evaporated to dryness. This gave an oil (0.63g, 70percent). MS (+ve ion electrospray) m/z 150 (MH+). |
70% | With sodium hydroxide; water In 1,4-dioxane at 20℃; for 18 h; | (d) Furo [2,3 -c]pyridin-5 -ylmethanol; A solution of furo[2,3-c]pyridin-5-ylmethyl acetate (1.15 g) in 1,4-dioxane (30 ml) and water (10 ml) was treated with 2M sodium hydroxide (12 ml) then stirred at ambient temperature for 18hrs. The mixture was then partitioned between ethyl acetate and water. The organics were separated and dried then evaporated to dryness. This gave an oil (0.63 g, 70percent). MS (+ve ion electrospray) m/z 150 (MH+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
27% | for 18 h; Heating / reflux | (c) Furo[2,3-clpyridin-5-ylmethyl acetate; {5-Hydroxy-4-[(trimethylsilyl)ethynyl]-2-pyridinyl}methyl acetate, trifluoroacetate) (10 g, 22 mmol) was dissolved in pyridine (200 ml) and treated with copper(l) iodide (5.2 g, 27 mmol) then heated under reflux for 18hrs. The mixture was allowed to cool, evaporated to dryness and the residue partitioned between ethyl acetate and water. This mixture was filtered through kieselguhr to remove copper residues. The organic layer was separated from the filtrate, dried and chromatographed on silica gel, eluting with a gradient of 10 - 60percent ethyl acetate in 40-600C petroleum ether. This gave furo[2,3-c]pyridin-5-ylmethyl acetate (1.15 g, 27percent) and a less polar product [2-(trimethylsilyl)furo[2,3-clpyridin- 5-yl]methyl acetate (1.3 g, 23percent) as oils.MS (+ve ion electrospray) m/z 192 (MH+) and MS (+ve ion electrospray) m/z 264 (MH+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | With 2,2,6,6-tetramethyl-piperidine-N-oxyl; trichloroisocyanuric acid; In acetone; at 20℃; for 0.0833333h;Cooling with ice; | a-9) Preparation of furo[2,3-c]pyridine-5-carbaldehyde Furo[2,3-c]pyridin-5-yl methanol (521 mg, 3.49 mmol) was dissolved in acetone (17 mL), added 2,2,6,6-tetramethylpiperidine 1-oxyl (27 mg, 170 mumol) at room temperature. Then, the reaction solution was added 1,3,5-trichloro-2,4,6-triazinetrione (892 mg, 3.84 mmol) under ice-cold conditions, and stirred at the same temperature for 5 minutes. The reaction solution was concentrated in vacuo, added water and a saturated aqueous solution of sodium hydrogen carbonate under ice-cold conditions, extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated in vacuo. The obtained residue was purified by silica-gel column chromatography (hexane/ethyl acetate), and the title compound (488 mg (yield 95%)) was obtained as a yellow solid. 1H-NMR (CDCl3) delta: 6.98 (1H, dd, J=0.8, 2.2 Hz), 7.88 (1H, d, J=2.2 Hz), 8.32 (1H, d, J=0.8 Hz), 9.03 (1H, s), 10.18 (1H, s). |
86% | Oxalyl chloride (685AL, 7.8 mmol) is dissolved in 30 mL CH2C12 in a dry flask under N2. The flask is placed in a DRY-ICE/ACETONE bath, DMSO (1. 11 mL, 15. 6 mmol) in 5 mL CH2C12 is added drop-wise, and the mixture is stirred for 20 min. C7 (1.0 g, 6.7 mmol) in 10 mL CH2C12 is added, and the reaction is stirred 30 min at - 78C. TEA (4.7 mL, 33.5 mmol) is added, the reaction is allowed to warm to rt, is stirred 1 h, and is washed with 25 mL saturated NAHC03. The organic layer is dried (K2CO3), filtered, and concentrated in vacuo to an orange solid. The crude material is chromatographed over 50 g silica gel (230-400 mesh) eluting with 33% EtOAc/ hexane. The fractions with the desired compound are combined and concentrated to provide furo [2,3-c] PYRIDINE-5-CARBALDEHYDE (C8 AS A WHITE SOLID (86% YIELD). MS (EI) for C8HSNO2, NILZ : 147 (M) +. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75% | With hydrogenchloride; zinc; In ethanol; water; at 70℃; for 1h;Heating / reflux; | C4 (32.0 g, 174 mmol) is combined with zinc powder (34.2 g, 523 mmol) in absolute EtOH (900 mL), using an overhead stirrer. The mixture is heated to 70C, HC1 (87.2 mL, 1.05 mol) is added slowly drop-wise, and the mixture is heated to reflux for 1 h. The mixture is cooled slightly, filtered to remove the metallic zinc and concentrated to near-dryness. The yellow oil is diluted with H20 (150 mL) and EtOAc (950 mL) and is treated slowly drop-wise with 20% Na2C03 (310 mL) as the mixture is warmed to reflux. The vigorously stirred (using overhead stirrer) mixture is refluxed for 1 h, cooled slightly and the organics removed via cannula under reduced pressure. Additional EtOAc (600 mL) is added, the mixture is heated to reflux for 1 h, cooled slightly and the organics removed as above. More EtOAc (600 mL) is added, the mixture is stirred at rt overnight then heated to reflux for 1 h, cooled slightly and most of the organics removed as above. The remaining mixture is filtered through celite, rinsed with EtOAc until no additional product elutes, and the layers separated. The aqueous layer is further extracted with EtOAc (2 X 400 mL). The combined organics are dried (MGS04) and concentrated to a dark yellow solid (23.6 g). The crude material is chromatographed over 900 g slurry-packed silica gel, eluting with 60% EtOAc/hexane (3 L), 70% EtOAc/hexane (2 L), and finally 100% EtOAc. The appropriate fractions are combined and concentrated in vacuo to'afford C7 (19.5 g, 75%) as a white solid. Anal. Calcd for CgH7NO2 : C, 64.42 ; H, 4.73 ; N, 9. 39 ; Found: C, 64.60 ; H, 4.56 ; N, 9.44. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
23%; 27% | With pyridine;copper(l) iodide; for 18h;Heating / reflux; | (c) Furo[2,3-clpyridin-5-ylmethyl acetate; {5-Hydroxy-4-[(trimethylsilyl)ethynyl]-2-pyridinyl}methyl acetate, trifluoroacetate) (10 g, 22 mmol) was dissolved in pyridine (200 ml) and treated with copper(l) iodide (5.2 g, 27 mmol) then heated under reflux for 18hrs. The mixture was allowed to cool, evaporated to dryness and the residue partitioned between ethyl acetate and water. This mixture was filtered through kieselguhr to remove copper residues. The organic layer was separated from the filtrate, dried and chromatographed on silica gel, eluting with a gradient of 10 - 60% ethyl acetate in 40-600C petroleum ether. This gave furo[2,3-c]pyridin-5-ylmethyl acetate (1.15 g, 27%) and a less polar product [2-(trimethylsilyl)furo[2,3-clpyridin- 5-yl]methyl acetate (1.3 g, 23%) as oils.MS (+ve ion electrospray) m/z 192 (MH+) and MS (+ve ion electrospray) m/z 264 (MH+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | With methanol; potassium carbonate; at 20℃; | a-8) Preparation of furo[2,3-c]pyridin-5-yl methanol Furo[2,3-c]pyridin-5-yl methyl acetate (722 mg, 3.78 mmol) was dissolved in methanol (19 mL), added potassium carbonate (1.04 g, 7.56 mmol) at room temperature, and the mixture was stirred at room temperature overnight. The reaction solution was added 1N-aqueous solution of hydrochloric acid under ice-cold conditions, and extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate, and concentrated in vacuo. The obtained residue was purified by silica-gel column chromatography (hexane/ethyl acetate), and the title compound (521 mg (yield 92%)) was obtained as a yellow oil. 1H-NMR (CDCl3) delta: 3.68 (1H, s), 4.85 (2H, s), 6.79 (1H, s), 7.54 (1H, s), 7.79 (1H, s), 8.83 (1H, s). |
70% | With sodium hydroxide; In 1,4-dioxane; water; | (d) Furo[2,3-c]pyridin-5-ylmethanol A solution of furo[2,3-c]pyridin-5-ylmethyl acetate (1.15 g) in 1,4-dioxane (30 ml) and water (10 ml) was treated with 2M sodium hydroxide (12 ml) then stirred at ambient temperature for 18hrs. The mixture was then partitioned between ethyl acetate and water. The organics were separated and dried then evaporated to dryness. This gave an oil (0.63 g, 70%). MS (+ve ion electrospray) m/z 150 (MH+). |
70% | With sodium hydroxide; water; In 1,4-dioxane; at 20℃; for 18h; | (d) Furo[2,3-c]pyridin-5-ylmethanol A solution of furo[2,3-c]pyridin-5-ylmethyl acetate (1.15 g) in 1,4-dioxane (30 ml) and water (10 ml) was treated with 2M sodium hydroxide (12 ml) then stirred at ambient temperature for 18 hrs. The mixture was then partitioned between ethyl acetate and water. The organics were separated and dried then evaporated to dryness. This gave an oil (0.63 g, 70%). MS (+ve ion electrospray) m/z 150 (MH+). |
70% | With sodium hydroxide; water; In 1,4-dioxane; at 20℃; for 18h; | (d) Furo[2,3-c]pyridin-5-ylmethanol; A solution of furo[2,3-clpyridin-5-ylmethyl acetate (1.15 g) in 1 ,4-dioxane(30 ml) and water (10 ml) was treated with 2M sodium hydroxide (12 ml) then stirred at ambient temperature for 18h. The mixture was then partitioned between <n="35"/>ethyl acetate and water. The organic fractions were separated and dried then evaporated to dryness. This gave an oil (0.63 g, 70%).MS (+ve ion electrospray) m/z 150 (MH+). |
70% | With sodium hydroxide; water; In 1,4-dioxane; at 20℃; for 18h; | (d) Furo[2,3-c]pyridin-5-ylmethanol; A solution of furo[2,3-c]pyridin-5-ylmethyl acetate (1.15 g) in 1,4-dioxane (30ml) and water (10ml) was treated with 2M sodium hydroxide (12ml) then stirred at ambient temperature for 18h. The mixture was then partitioned between ethyl acetate and water. The organic fractions were separated and dried then evaporated to dryness. This gave an oil (0.63g, 70%). MS (+ve ion electrospray) m/z 150 (MH+). |
70% | With sodium hydroxide; water; In 1,4-dioxane; at 20℃; for 18h; | (d) Furo [2,3 -c]pyridin-5 -ylmethanol; A solution of furo[2,3-c]pyridin-5-ylmethyl acetate (1.15 g) in 1,4-dioxane (30 ml) and water (10 ml) was treated with 2M sodium hydroxide (12 ml) then stirred at ambient temperature for 18hrs. The mixture was then partitioned between ethyl acetate and water. The organics were separated and dried then evaporated to dryness. This gave an oil (0.63 g, 70%). MS (+ve ion electrospray) m/z 150 (MH+). |
With sodium hydroxide; water; In 1,4-dioxane; at 20℃; for 18h;Product distribution / selectivity; | (d) Furo[2,3-c]pyridin-5-ylmethanol[2-(Trimethylsilyl)furo[2,3-c]pyridin-5-yl]methyl acetate (1.3g, 4.9mmol) was dissolved in ethanol (50ml) and treated with potassium carbonate (0.82g, 5.9mmol) and heated under reflux for 18 hrs. The mixture was evaporated to dryness and the residue partitioned between ethyl acetate and water. The organic layer was dried, filtered and evaporated to yield the title compound (0.66g).Also to yield the desired compound: Furo[2,3-c]pyridin-5-ylrnethyl acetate (1.15g, mmol) was dissolved in 1,4-dioxane (30ml) and water (10ml) and treated with 2N sodium hydroxide solution (12ml) and stirred at RT for 18h. The mixture was then partitioned between ethyl acetate and water, the organic layer was dried and evaporated to dryness to provide the desired compound (0.63g). MS (ES+) m/z 150 (MH+, 90%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With hydrogen;palladium 10% on activated carbon; In ethanol; at 20℃; under 760.051 Torr; for 18h; | (e) 2,3-Dmydro<strong>[478148-60-6]furo[2,3-c]pyridin-5-ylmethanol</strong>Furo[2,3-c]pyridin-5-ylmethanol (1.29g, 8.7mmol) was dissolved in ethanol (50ml) and hydrogenated under 1 atmosphere of hydrogen at room temperature over 10% palladium on carbon for 18h. The mixture was filtered and the filtrate evaporated to dryness to provide the desired compound (1.3 Ig, 100%). MS (ES+) m/z 152 (MH+, 100%). |
100% | With hydrogen;palladium 10% on activated carbon; In ethanol; at 0℃; under 760.051 Torr; for 18h; | (e) 2,3-Dihydro<strong>[478148-60-6]furo[2,3-c]pyridin-5-ylmethanol</strong> Furo[2,3-c]pyridin-5-ylmethanol (1.29 g, 8.7 mmoles) was dissolved in ethanol (50 ml) and hydrogenated at S.T.P (standard temperature and pressure) over 10% palladium on charcoal paste for 18 hrs. The mixture was filtered through kieselguhr and the filtrate evaporated to dryness, to give (1.31 g, 100%). MS (+ve ion electrospray) m/z 152 (MH+). |
100% | With hydrogen;palladium 10% on activated carbon; In ethanol; at 20℃; for 18h; | (e) 2,3-Dihydro<strong>[478148-60-6]furo[2,3-c]pyridin-5-ylmethanol</strong>; Furo[2,3-c]pyridin-5-ylmethanol (1.29 g, 8.7 mmol) was dissolved in ethanol (50 ml) and hydrogenated at RT, 1 atmosphere over 10% palladium on charcoal paste for 18h. The mixture was filtered through kieselguhr and the filtrate evaporated to dryness, to give (1.31 g, 100%). MS (+ve ion electrospray) m/z 152 (MH+). |
100% | With hydrogen;palladium 10% on activated carbon; In ethanol; at 20℃; under 760.051 Torr; for 18h; | (e) 2,3-Dihydro<strong>[478148-60-6]furo[2,3-c]pyridin-5-ylmethanol</strong>; Furo[2,3-c]pyridm-5-ylmethanol (1.29g, 8.7 mmol) was dissolved in ethanol(50ml) and hydrogenated at rt, 1 atmosphere over 10% palladium on charcoal paste for18h. The mixture was filtered through kieselguhr and the filtrate evaporated to dryness, to give (1.3 Ig, 100%).MS (+ve ion electrospray) m/z 152 (MH+). |
100% | With hydrogen;palladium 10% on activated carbon; In ethanol; at 0℃; under 750.075 Torr; for 18h; | (e) 2,3-Dihydro<strong>[478148-60-6]furo[2,3-c]pyridin-5-ylmethanol</strong>; Furo[2,3-c]pyridin-5-ylmethanol (1.29 g, 8.7 mmoles) was dissolved in ethanol(50 ml) and hydrogenated at S. T. P (standard temperature and pressure) over 10% palladium on charcoal paste for 18hrs. The mixture was filtered through kieselguhr and the filtrate evaporated to dryness, to give (1.31 g, 100%). MS (+ve ion electrospray) m/z 152 (MH+). |
palladium on charcoal; In ethanol; | (e) 2,3-Dihydro<strong>[478148-60-6]furo[2,3-c]pyridin-5-ylmethanol</strong> Furo[2,3-c]pyridin-5-ylmethanol (1.29 g, 8.7 mmoles) was dissolved in ethanol (50 ml) and hydrogenated at S.T.P (standard temperature and pressure) over 10% palladium on charcoal paste for 18hrs. The mixture was filtered through kieselguhr and the filtrate evaporated to dryness, to give (1.31 g, 100%). MS (+ve ion electrospray) m/z 152 (MH+). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With ethanol; potassium carbonate; for 18h;Heating / reflux;Product distribution / selectivity; | (d) Furo[2,3-c]pyridin-5-ylmethanol[2-(Trimethylsilyl)furo[2,3-c]pyridin-5-yl]methyl acetate (1.3g, 4.9mmol) was dissolved in ethanol (50ml) and treated with potassium carbonate (0.82g, 5.9mmol) and heated under reflux for 18 hrs. The mixture was evaporated to dryness and the residue partitioned between ethyl acetate and water. The organic layer was dried, filtered and evaporated to yield the title compound (0.66g).Also to yield the desired compound: Furo[2,3-c]pyridin-5-ylrnethyl acetate (1.15g, mmol) was dissolved in 1,4-dioxane (30ml) and water (10ml) and treated with 2N sodium hydroxide solution (12ml) and stirred at RT for 18h. The mixture was then partitioned between ethyl acetate and water, the organic layer was dried and evaporated to dryness to provide the desired compound (0.63g). MS (ES+) m/z 150 (MH+, 90%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94% | With pyridine; at 20℃; for 18h; | FURO [2, 3-c] pyridin-5-ylmethanol (7.70 g, 51.63 mmol) is dissolved in pyridine (45 mL), treated with acetic anhydride (14.36 ML, 154.9 mmol) and stirred for 18 h at rt. The pyridine is removed in vacuo and the resulting residue dissolved in EtOAc (200 mL), washed with 50% saturated sodium bicarbonate (4 x 90 mL), dried (MGS04) and concentrated in vacuo to afford 9.32 g (94%) of furo [2,3-c] pyridin-5- ylmethyl acetate as a yellow oil. MS (EI) M/Z : 191 (M+), 277,148, 119,118, 86,84, 77,63, 51,50.. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | With sodium hydroxide; In methanol; water; | C14 (770 mg, 3.48 mmol) is dissolved in 10 mL MeOH. 2N NaOH (3 mL, 6 mmol) is added, and the reaction is stirred for 1.5 h at rt. The solution is concentrated in vacuo to a residue. Water (20 mL) is added to the residue and extracted with 4*10 mL CH2Cl2. The combined organic layer is dried over K2CO3, filtered, and then concentrated in vacuo to afford furo[2,3-c]pyridin-5-yl methanol (C16) as a white solid (90% yield). Analysis calculated for C8H7NO2: C, 64.42; H, 4.73; N, 9.39. Found: C, 64.60; H. 4.56; N, 9.44. |
90% | With sodium hydroxide; In methanol; water; at 20℃; for 1.5h; | C6 (770 mg, 3.48 mmol) is dissolved in 10 mL MEOH. 2N NAOH (3 mL, 6 mmol) is added, and the reaction is stirred for 1.5 h at rt. The solution is concentrated in vacuo to a residue. Water (20 mL) is added to the residue and extracted with 4 x 10 mL CH2C12. The combined organic layer is dried (K2CO3), filtered, and then concentrated in vacuo to afford furo [2,3-c] PYRIDIN-5-YL methanol (2 AS A WHITE SOLID (90% yield). Analysis calculated for CSH7NO2 : C, 64.42 ; H, 4.73 ; N, 9.39. Found: C, 64.60 ; H, 4.56 ; N, 9.44. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | C14 (770 mg, 3.48 mmol) is dissolved in 10 mL MeOH. 2N NaOH (3 mL, 6 mmol) is added, and the reaction is stirred for 1.5 h at rt. The solution is concentrated in vacuo to a residue. Water (20 mL) is added to the residue and extracted with 4*10 mL CH2Cl2. The combined organic layer is dried over anhydrous K2CO3, filtered, and concentrated in vacuo to afford furo[2,3-c]pyridin-5-yl methanol (C16) as a white solid (90% yield). Analysis calculated for C8H7NO2: C, 64.42; H, 4.73; N, 9.39. Found: C, 64.60; H, 4.56; N, 9.44. | |
469 mg (90%) | 5-Hydroxymethyl-2-trimethylsilyl-furo[2,3c]pyridine (770 mg, 3.48 mmol) is dissolved in 10 ml MeOH. 2N NaOH (3 ml, 6 mmol) is added, the reaction is stirred for 1.5 h at rt, and the mixture is concentrated in vacuo. The residue is partitioned between 1*20 ml water and CH2Cl2 (4*10 ml), and the combined organic layer is dried over K2CO3. The dried organic layer is concentrated in vacuo to afford 469 mg (90%) of furo[2,3-c]pyridin-5-yl methanol as a white solid. Analysis: Calculated for C8H7NO2: C, 64.42; H, 4.73; N, 9.39. Found: C, 64.60; H, 4.56; N, 9.44. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
86% | With triethanolamine; In dichloromethane; dimethyl sulfoxide; | Oxalyl chloride (685 muL, 7.8 mmol) is dissolved in 30 mL CH2Cl2 in a dry flask under N2. The flask is placed in a dry-ice/acetone bath, DMSO (1.11 mL, 15.6 mmol) in 5 mL CH2Cl2 is added drop-wise, and the mixture is stirred for 20 min. C16 (1.0 g, 6.7 mmol) in 10 mL CH2Cl2 is added, and the reaction is stirred 30 min at -78 C. TEA (4.7 mL, 33.5 mmol) is added, the reaction is allowed to warm to rt, is stirred 1 h, and is washed with 25 mL saturated NaHCO3. The organic layer is dried over anhydrous K2CO3, filtered, and is concentrated in vacuo to an orange solid. The crude material is chromatographed over 50 g silica gel (230-400 mesh) eluding with 33% EtOAc/hexane. The fractions with the desired compound are combined and concentrated to provide furo[2,3-c]pyridine-5-carbaldehyde (C17) as a white solid (86% yield). MS (EI) for C8H5NO2, m/z: 147 (M)+. |
850 mg (86%) | With triethylamine; In dichloromethane; dimethyl sulfoxide; | Oxalyl chloride (685 muL, 7.8 mmol) is dissolved in 30 ml CH2Cl2 in a dried flask under nitrogen. The solution is cooled in a dry ice/acetone bath, is treated drop-wise with DMSO (1.11 ml, 15.6 mmol) in 1*5 ml CH2Cl2, and the mixture is stirred for 20 min. The mixture is treated with furo[2,3-c]pyridin-5-yl methanol (1.0 g, 6.7 mmol) in 1*10 ml CH2Cl2, is stirred 30 min at in a dry ice/acetone bath, and is treated with Et3N (4.7 ml, 33.5 mmol). The reaction is allowed to warm to rt, is stirred 1 h, and is washed with 1*25 ml saturated NaHCO3. The organic layer is dried over K2CO3 and is concentrated in vacuo to an orange solid. The crude material is chromatographed over 50 g silica gel (230-400 mesh) eluding with 33% EtOAc/hexane. The appropriate fractions are combined and concentrated to provide 850 mg (86%) of furo[2,3-c]pyridine-5-carbaldehyde as a white solid. MS for C8H5NO2, (EI) m/z: 147 (M)+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
9.32 g (94%) | With acetic anhydride; In pyridine; ethyl acetate; | EXAMPLE 18 N-[(1S,2R,4R)-7-azabicyclo[2.2.1]hept-2-yl]-3-chlorofuro[2,3-c]pyridine-5-carboxamide dihydrochloride Furo[2,3-c]pyridin-5-ylmethanol (7.70 g, 51.63 mmol) is dissolved in pyridine (45 mL), treated with acetic anhydride (14.36 mL, 154.9 mmol) and stirred for 18 h at RT. The pyridine is removed under high vacuum, and the resulting residue is dissolved in EtOAc (200 mL), washed with 50% saturated sodium bicarbonate (4*90 mL), dried over MgSO4 and concentrated in vacuo to afford 9.32 g (94%) of furo[2,3-c]pyridin-5-ylmethyl acetate as a yellow oil. MS (EI) m/z: 191 (M+), 277, 148, 119, 118, 86, 84, 77, 63, 51, 50.. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
9.32 g (94%) | With acetic anhydride; In pyridine; ethyl acetate; | EXAMPLE 28 N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-3-chlorofuro[2,3-c]pyridine-5-carboxamide Dihydrochloride Preparation of the Acid: Furo[2,3-c]pyridin-5-ylmethanol (7.70 g, 51.63 mmol) is dissolved in pyridine (45 mL), treated with acetic anhydride (14.36 mL, 154.9 mmol) and stirred for 18 h at rt. The pyridine is removed in vacuo and the resulting residue dissolved in EtOAc (200 mL), washed with 50% saturated sodium bicarbonate (4*90 mL), dried over MgSO4 and concentrated in vacuo to afford 9.32 g (94%) of furo[2,3-c]pyridin-5-ylmethyl acetate as a yellow oil. MS (EI) m/z: 191 (M+), 277, 148, 119, 118, 86, 84, 77, 63, 51, 50. |
Tags: 478148-60-6 synthesis path| 478148-60-6 SDS| 478148-60-6 COA| 478148-60-6 purity| 478148-60-6 application| 478148-60-6 NMR| 478148-60-6 COA| 478148-60-6 structure
A299323 [655239-64-8]
5,6,7,8-Tetrahydroquinolin-3-ol
Similarity: 0.70
A268393 [2598-30-3]
8-Hydroxyquinoline-5-carbaldehyde
Similarity: 0.66
A297042 [478148-62-8]
Furo[2,3-c]pyridine-5-carboxylic acid
Similarity: 0.87
A108733 [478148-61-7]
Furo[2,3-c]pyridine-5-carboxaldehyde
Similarity: 0.85
A229772 [527681-61-4]
3,4-Dihydro-2H-pyrano[2,3-c]pyridine-6-carbaldehyde
Similarity: 0.74
A202100 [112372-15-3]
Furo[2,3-c]pyridine-2-carboxylic acid
Similarity: 0.70
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :
Total Compounds: mg
The concentration of the dissolution solution you need to prepare is mg/mL