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Chemical Structure| 478040-59-4 Chemical Structure| 478040-59-4

Structure of 478040-59-4

Chemical Structure| 478040-59-4

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Product Details of [ 478040-59-4 ]

CAS No. :478040-59-4
Formula : C8H5IN2O2
M.W : 288.04
SMILES Code : O=C(C1=CN2C=C(I)C=CC2=N1)O
MDL No. :MFCD02186210

Safety of [ 478040-59-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 478040-59-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 478040-59-4 ]

[ 478040-59-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 478040-59-4 ]
  • [ 108511-97-3 ]
  • [ 1168157-29-6 ]
YieldReaction ConditionsOperation in experiment
With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 50℃; for 16h; To a suspension of 200 mg of 6-iodoimidazo[1,2-a]pyridine-2-carboxylic acid and 266 mg of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride in 1 mL of anhydrous pyridine are added 175 mg of <strong>[108511-97-3]isoxazol-4-ylamine</strong>. The reaction mixture is stirred for 16 hours at 50° C. and then concentrated under reduced pressure. The residue is taken up in 10 mL of a mixture of chloroform and water (1/1). The solid is triturated with 3 mL of water, filtered off by suction and washed with 3 mL of water and then with 3 mL of ethyl ether, and dried to give 280 mg of 6-iodo-N-(isoxazol-4-yl)imidazo[1,2-a]pyridine-2-carboxamide in the form of a beige-coloured solid. 1H NMR spectrum (DMSO-d6, delta in ppm): 10.93 (broad s, 1H), 9.24 (broad s, 1H), 9.02 (broad s, 1H), 8.81 (broad s, 1H), 8.43 (broad s, 1H), 7.60-7.48 (m, 2H). Mass spectrum (APCI): m/z=258 [M+H]+.
 

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