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Chemical Structure| 4771-08-8

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Product Details of [ 4771-08-8 ]

CAS No. :4771-08-8
Formula : C13H10N2O3
M.W : 242.23
SMILES Code : O=C(NC1=CC=CC([N+]([O-])=O)=C1)C2=CC=CC=C2
MDL No. :MFCD00043537

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 4771-08-8 ]

[ 4771-08-8 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 4771-08-8 ]
  • [ 16091-26-2 ]
YieldReaction ConditionsOperation in experiment
89.8% With iron; ammonium chloride In ethanol; water for 2 h; Reflux Compound 10a was dissolved in EtOH (20 ml), and an aqueous solution of iron powder (2.5 g) and ammonium chloride (0.53 g, 10 mmol) was added and the reaction was refluxed for 2 hours. Followed by hot filter, collected filtrate spin dry. The solid was dissolved in acetone and the filtrate was collected by filtration and the solution was spin-dried to give compound 11a in 89.8percent yield.
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[4] Patent: CN106699755, 2017, A, . Location in patent: Paragraph 0103; 0195; 0196.
[5] Journal of Chemical Research, 2006, # 4, p. 223 - 224.
[6] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 9, p. 3088 - 3115.
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[8] Chemische Berichte, 1874, vol. 7, p. 498.
[9] Helvetica Chimica Acta, 1937, vol. 20, p. 691,699.
[10] Journal fuer Praktische Chemie (Leipzig), 1986, vol. 328, # 4, p. 497 - 514.
[11] Journal of Medicinal Chemistry, 1986, vol. 29, # 3, p. 417 - 423.
[12] Arzneimittel-Forschung/Drug Research, 1999, vol. 49, # 2, p. 81 - 87.
[13] Chemical Communications, 2005, # 43, p. 5438 - 5440.
[14] Journal of Organic Chemistry, 2009, vol. 74, # 11, p. 4272 - 4277.
[15] Journal of Medicinal Chemistry, 2012, vol. 55, # 4, p. 1559 - 1571.
[16] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 16, p. 3968 - 3973.
[17] European Journal of Medicinal Chemistry, 2017, vol. 136, p. 372 - 381.
 

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