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Chemical Structure| 475473-26-8 Chemical Structure| 475473-26-8
Chemical Structure| 475473-26-8

CORM-3

CAS No.: 475473-26-8

CORM-3 is a water-soluble carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.

Synonyms: CORM-3

4.5 *For Research Use Only !

Cat. No.: A812133 Purity: 97%

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Product Details of CORM-3

CAS No. :475473-26-8
Formula : C5H4ClNO5Ru
M.W : 294.61
SMILES Code : O=C1C[NH2][Ru-3](Cl)([C+]=O)([C+]=O)([C+]=O)O1
Synonyms :
CORM-3
MDL No. :MFCD07364048

Safety of CORM-3

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Related Pathways of CORM-3

pyroptosis

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description Reference
H9c2 cells 100 µM 1 hour To evaluate H2O2-induced apoptosis and cell death, results showed that HO-1 TG myocytes were resistant to H2O2-induced cell death PMC2917269
Cardiomyocytes 100 µM 30 minutes To evaluate the effect of CORM-3 on mitochondrial membrane potential, results showed that CORM-3 pretreatment attenuated PAO-induced MPT PMC2917269
Primary hepatocytes 10 μM 24 hours To evaluate the effect of ethanol on hepatocyte death, it was found that ethanol increased the sensitivity of hepatocytes to TNF α-induced cell death, which was attenuated by the necroptosis inhibitor necrostatin-1 but not by caspase inhibitors. Induction of HO-1 or treatment with CORM-3 normalized the sensitivity of hepatocytes to TNF α-induced cell death. PMC4203703
Caco-2 cells 4.5 μM 4 hours To assess the anti-inflammatory effects of BSA–RuII(CO)2 complex, results showed downregulation of TNF-α, IL-6, and IL-10 expression levels. PMC4506567
HeLa cells 1.5 μM 30 minutes To evaluate the ability of BSA–RuII(CO)2 complex to release CO in HeLa cells, results showed a significant increase in intracellular fluorescence indicating CO release. PMC4506567
Human colon carcinoma cell line RKO 25 μM 1 hour To assess the cytotoxicity of CORM-3 on mammalian cells and its intracellular Ru accumulation. Results demonstrated that CORM-3 significantly reduced cell survival, correlating with intracellular Ru accumulation levels. PMC6067063
Escherichia coli K-12 strain MG1655 60 μM 1 hour To evaluate the antimicrobial activity of CORM-3 against E. coli and its intracellular Ru accumulation. Results showed that CORM-3 significantly inhibited bacterial growth and increased intracellular Ru levels, directly correlating with cytotoxicity. PMC6067063
Primary neurons 100 μM 3 hours pretreatment To evaluate the effect of CORM-3 on neurons under oxygen-glucose deprivation (OGD) conditions, results showed that CORM-3 inhibited OGD-induced IRE1 phosphorylation and inflammasome expression PMC6412161

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description Reference
Mice Myocardial infarction model Intraperitoneal injection 40 mg/kg Once daily for 24 days To evaluate the effect of CORM-3 on post-infarction LV remodeling, results showed that CORM-3 treatment attenuated LV dilatation and dysfunction PMC2917269
C57BL/6J mice Chronic ethanol-induced liver injury model Intraperitoneal injection 3 mg/kg Once daily for 5 days To evaluate the therapeutic effect of CORM-A1 on ethanol-induced liver injury, it was found that CORM-A1 reduced ethanol-induced increases in AST and ALT, decreased expression of inflammatory cytokines TNF α, IL6 and CXCL10, and reduced accumulation of the hepatocyte death marker M30 and expression of RIP3. PMC4203703
Balb/C athymic nude mice CT-26 colon carcinoma model Intravenous injection 3 mg/kg Single dose, sacrificed after 4 hours To evaluate CO release and accumulation from BSA–RuII(CO)2 complex in tumors, results showed CO levels at the tumor were threefold higher compared to blood. PMC4506567
Rats Spinal cord injury model 8 mg/kg CORM-3 alleviates neuron death by inhibiting the activation of caspase-1 and caspase-11 and the release of pro-inflammatory factors IL-1β and IL-18 PMC7753222
Sprague-Dawley rats Spinal cord injury model Tail vein injection 8 mg/kg/day Once daily until sacrifice To evaluate the effect of CORM-3 on neuron death and motor functional recovery after spinal cord injury, results showed that CORM-3 alleviated neuron death and improved motor functional recovery PMC6412161

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.37mL

0.67mL

0.34mL

16.86mL

3.37mL

1.69mL

33.71mL

6.74mL

3.37mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

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