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Chemical Structure| 4750-28-1 Chemical Structure| 4750-28-1

Structure of 4750-28-1

Chemical Structure| 4750-28-1

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Product Details of [ 4750-28-1 ]

CAS No. :4750-28-1
Formula : C12H10ClNO2S
M.W : 267.73
SMILES Code : O=S(C1=CC=CC=C1)(NC2=CC=C(Cl)C=C2)=O
MDL No. :MFCD00541864

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Application In Synthesis of [ 4750-28-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4750-28-1 ]

[ 4750-28-1 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 98-10-2 ]
  • [ 14752-66-0 ]
  • [ 4750-28-1 ]
YieldReaction ConditionsOperation in experiment
81% With dichloro bis(acetonitrile) palladium(II); silver(I) acetate; In 1,4-dioxane; dimethyl sulfoxide; at 120℃; for 24h;Inert atmosphere; Schlenk technique; General procedure: Under the argon atmosphere, a Schlenk tube (15 mL) equipped with a magnetic bar was loaded with the sulfonamide 1 (0.5 mmol), sodium arylsulfinates 2 (0.6 mmol, 1.2 equiv.), Pd(MeCN)2Cl2 (6.5 mg, 5 mol%) and AgOAc (166.9 mg, 1.0 mmol) in one portion. Then, the mixture of 1,4-dioxane/DMSO (3.5 mL in a 9:1 ratio) was added to obtain a clear solution and the reaction mixture was allowed to stir at 120 C for 24 h. After cooling to room temperature, the mixture was filtered through a short celite pad and washed with dichloromethane (15 mL 3). The filtrate was concentrated and the oily crude product was purified by column chromatography using silica gel (200-300 mesh) as stationary phase and a petroleum ether and ethyl acetate (3/1) as eluent to give the N-aryl sulfonamides 3 in noted yields.
  • 2
  • [ 15181-11-0 ]
  • [ 4750-28-1 ]
  • 2-(tert-butyl)-6-chloro-4-methyl-9-(phenylsulfonyl)carbazole [ No CAS ]
  • 3
  • [ 15181-11-0 ]
  • [ 4750-28-1 ]
  • N-(2′,4′-di-tert-butyl-5-chloro-6′-methyl-[1,1′-biphenyl]-2-yl)benzenesulfonamide [ No CAS ]
 

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