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Chemical Structure| 468741-20-0 Chemical Structure| 468741-20-0

Structure of 468741-20-0

Chemical Structure| 468741-20-0

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Product Details of [ 468741-20-0 ]

CAS No. :468741-20-0
Formula : C11H15N3O3
M.W : 237.26
SMILES Code : NC1=C([N+]([O-])=O)C=C(N2CCOCC2)C=C1C
MDL No. :MFCD08236744

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Application In Synthesis of [ 468741-20-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 468741-20-0 ]

[ 468741-20-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 468741-20-0 ]
  • [ 134221-52-6 ]
  • [ 847776-30-1 ]
YieldReaction ConditionsOperation in experiment
64% To a stirred solution of 2-methyl-4-morpholin-4-yl-6-nitro-phenyl amine (0.290 g, 1.22 mmol) in methanol (40 mL) was added 10% palladium on carbon (180 mg) and the suspension flushed well with nitrogen, followed by hydrogen. The resulting suspension was stirred 8 hours at room temperature under an atmosphere of hydrogen (ca. 1 atm). The resulting suspension was filtered under nitrogen through a pad of Celite and washed with methanol (50 mL). This solution was cooled down to 0 C. and the <strong>[134221-52-6]4-chloro-2,6-dimethoxy-pyrimidine-5-carbaldehyde</strong> (N. Ple et al. J. Heterocyclic Chem., 28, 283, 1991 (0.272 g, 1.34 mmol) in methanol (50 ml) was added and the reaction mixture as stirred exposed to air at 23 C. for 18 hours. MeOH was evaporated in vacuo and the crude material was purified on silicagel dry column using CH2Cl2: Isopropanol (9:1) to give the title compound as a yellow solid. (0.304 g, 64%), HPLC: 98% (220 nm), LCMS (+ESI, M+H+) m/z 390, IR (KBr, cm-1) 3421, 2955, 2854, 1602, 1540, 1385; 1H NMR (400 MHz, DMSO) delta 6.70 (br s, 2H), 3.87 (s, 3H), 3.80 (s, 3H), 3.63 (m, 4H), 2.94 (m, 4H), 2.34 (s, 3H);
 

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