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Chemical Structure| 460747-73-3 Chemical Structure| 460747-73-3

Structure of 460747-73-3

Chemical Structure| 460747-73-3

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Product Details of [ 460747-73-3 ]

CAS No. :460747-73-3
Formula : C9H15N
M.W : 137.22
SMILES Code : C[C@H]1N(CCC#C)CCC1
MDL No. :MFCD09029633

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Application In Synthesis of [ 460747-73-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 460747-73-3 ]

[ 460747-73-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 2296-23-3 ]
  • [ 460747-73-3 ]
  • [ 460747-72-2 ]
  • 2
  • [ 460746-47-8 ]
  • [ 460747-73-3 ]
  • [ 460746-46-7 ]
YieldReaction ConditionsOperation in experiment
With diisopropylamine;bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In acetonitrile; at 20℃; The solution from Example 2A (3.02 g, 22.0 mmol) in CH3CN (49.5 ML) was purged with nitrogen and treated with the product from Example 1A (3.21 g, 10.0 mmol), CuI (38 mg, 0.2 mmol), PdCl2 (Ph3P)2 (70 mg, 0.2 mmol), and diisopropylamine (8.4 ml, 60 mmol).The mixture was stirred at room temperature under nitrogen until reaction was near complete by HPLC. The reaction mixture was concentrated to about 30 ML, treated with toluene (100 ML), washed with 5% NaHCO3 (2*100 ML), and 10% NH4Cl (2*100 ML).The organic layer was separated, filtered through a pad of Celite, and extracted with (CH3SO3H:N-methylpyrrolidinone:H2O, 10:20:70) (2*100 ML).The aqueous layer was extracted with IPAC (2*100 ML), basified with 50% NaOH, and extracted with IPAC (2*100).The organic layer was washed with 5% NaHCO3 (2*100 ML), 25% brine (100 ML), and treated with active carbon, silica gel (6.0 g), and Na2SO3 (1.0 g).The mixture was stirred at room temperature for 1 hour and filtered. The filtrate was concentrated to dryness to provide the title compound.
 

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