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Chemical Structure| 459819-54-6 Chemical Structure| 459819-54-6

Structure of 459819-54-6

Chemical Structure| 459819-54-6

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Product Details of [ 459819-54-6 ]

CAS No. :459819-54-6
Formula : C17H22F3NO3
M.W : 345.36
SMILES Code : O=C(N1CCC(C2=CC=C(OC(F)(F)F)C=C2)CC1)OC(C)(C)C

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Application In Synthesis of [ 459819-54-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 459819-54-6 ]

[ 459819-54-6 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 459819-54-6 ]
  • [ 1004618-85-2 ]
YieldReaction ConditionsOperation in experiment
100% With hydrogenchloride In methanol at 20℃; for 3 h; (3) 4-(4-(trifluoromethoxy)phenyl)piperidine [0076] 4-(4-(trifluoromethoxy)phenyl)piperidine-1-formic acid tert-butyl ester (1.73 g, 5 mmol) was dissolved in methanol (15 ml), added HCl/MeOH saturated solution (15 ml), stirred for 3 h at room temperature, removed solvents under reduced pressure, residuals were washed by ethyl ether to give 1.4 g white solid, i.e. 4-(4-(trifluoromethoxy)phenyl)piperidine hydrochloride, yield was 100 percent.MS (ESI/LR): 246.1 [M+1]+.
References: [1] Patent: EP2573090, 2013, A1, . Location in patent: Paragraph 0075-0076.
 

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