4542-75-0|4,4'-Oxybis((bromomethyl)benzene)| Ambeed

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Quality Control of [ 4542-75-0 ] Purity: 95% SDS Specification

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Product Details of [ 4542-75-0 ]

CAS No. :	4542-75-0
Formula :	C₁₄H₁₂Br₂O
M.W :	356.05
SMILES Code :	BrCC1=CC=C(OC2=CC=C(CBr)C=C2)C=C1
MDL No. :	MFCD08063928
InChI Key :	QPSFOUFNVQVKKJ-UHFFFAOYSA-N
Pubchem ID :	10269629

Safety of [ 4542-75-0 ]

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H302-H335-H314
Precautionary Statements:	P260-P264-P270-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P403+P233-P405-P501
Class:	8
UN#:	3261
Packing Group:	Ⅱ

Application In Synthesis of [ 4542-75-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 4542-75-0 ]

[ 4542-75-0 ] Synthesis Path-Downstream 1~35

1
[ 100-97-0 ]
[ 4542-75-0 ]
[ 2215-76-1 ]

References: [1]Pharmaceutical Bulletin,1957,vol. 5,p. 619.

2
[ 1579-40-4 ]
[ 4542-75-0 ]

Yield	Reaction Conditions	Operation in experiment
93%	With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; at 80 - 90℃; for 6.5h;Inert atmosphere;	Prior to use, NBS was recrystallized from water and the carbon tetrachloride was bubbled with nitrogen, stirred for 45 min with sodium sulfate, and checked by 1H-NMR spectroscopy. To a stirred solution of 4,4'-oxybis(methylbenzene) (28) (5.0 g, 25.2 mmol, 1 eq.) and NBS (8.98 g, 50.4 mmol, 2 eq.) in carbon tetrachloride (125 mL) under nitrogen was added a catalytic amount of AIBN. The reaction mixture was heated to 80-90 C (reflux) and stirred for 6.5 h. The solution was then cooled and the succinimide was removed on a sintered glass filter funnel. The solvent was removed in vacuo to yield the desired product 29 as beige crystals (8.3 g, 93%). A portion (1.82 g) was purified by flash chromatography (10:1 hexane:EtOAc) to yield 29 as white crystals: mp 85-86 C (lit.29 mp 93-95 C). 1H NMR (CDCl3): δ 7.38 (d, 4H), 6.98 (d, 4H), 4.52 (s, 4H).
	With hydrogen bromide; dihydrogen peroxide; In 1,2-dichloro-ethane; for 12h;Cooling with ice; Irradiation;	82 g (1.2 mol) of 50% hydrogen peroxide was slowly added into a mixture of 109 g (0.55 mol) of 4,4'-oxybis(methylbenzene) and 370 g (2.2 mol) of hydrobromic acid in 1000 g of DCE under ice bath. The resulting mixture was irradiated by a visible light lamp (with a wavelength of about 400 nm) for 12 hours to form a crude product (in an organic layer). 4,4'-oxybis((bromomethyl)benzene) was obtained with a yield of 650% after removing the solvent from the crude product by evaporation.

References: [1]Arkivoc,2018,vol. 2018,p. 334 - 347.
[2]Pharmaceutical Bulletin,1957,vol. 5,p. 619.
[3]Journal of the Chemical Society,1961,p. 1604 - 1610.
[4]Chemistry - A European Journal,1997,vol. 3,p. 1537 - 1541.
[5]Patent: US2017/36981,2017,A1 .Location in patent: Paragraph 0176; 0177.

3
[ 4542-75-0 ]
[ 194-00-3 ]
2,2'-(oxydibenzyl)bis(2,7-diazapyrenium) dibromide [ No CAS ]

References: [1]Helvetica Chimica Acta,1987,vol. 70,p. 1 - 12.

4
[ 4542-75-0 ]
[ 13925-27-4 ]
C₄₆H₃₂N₆O₃ [ No CAS ]

References: [1]Journal of Heterocyclic Chemistry,1980,vol. 17,p. 433 - 437.

5
[ 4542-75-0 ]
[ 2129-89-7 ]
bis<4-<2-(diphenylphosphinyl)ethyl>phenyl>ether [ No CAS ]

References: [1]Bulletin of the Chemical Society of Japan,1993,vol. 66,p. 1837 - 1839.

6
[ 120-43-4 ]
[ 4542-75-0 ]
C₂₈H₃₈N₄O₅ [ No CAS ]

References: [1]Chemische Berichte,1994,vol. 127,p. 2267 - 2272.

7
[ 4542-75-0 ]
bis-(4-iodomethyl-phenyl)-ether [ No CAS ]

References: [1]Journal of the Chemical Society,1961,p. 1604 - 1610.

8
[ 4542-75-0 ]
[ 1579-40-4 ]

References: [1]Journal of the Chemical Society,1961,p. 1604 - 1610.

9
[ 4542-75-0 ]
[ 64-19-7 ]
[ 2416-40-2 ]

References: [1]Journal of the Chemical Society,1961,p. 1604 - 1610.

10
[ 110-85-0 ]
[ 4542-75-0 ]
1,3,7,9(1,4)-Tetrabenzena-2,8-dioxo-5,11(1,4)dipiperazinacyclodecaphane [ No CAS ]

References: [1]Liebigs Annalen,1995,p. 1611 - 1616.

11
[ 4542-75-0 ]
[ 121-45-9 ]
bis[p-(dimethoxyphosphorylmethyl)phenyl] ether [ No CAS ]

References: [1]Chemistry - A European Journal,1997,vol. 3,p. 1537 - 1541.

12
[ 4542-75-0 ]
{4-[4-(4,4,8,8-Tetramethyl-2-oxo-2λ⁵-[1,3,6,2]dioxazaphosphocane-6-carbonyl)-phenoxy]-phenyl}-(4,4,8,8-tetramethyl-2-oxo-2λ⁵-[1,3,6,2]dioxazaphosphocan-6-yl)-methanone [ No CAS ]
C₄₄H₅₂N₂O₁₀P₂ [ No CAS ]

References: [1]Tetrahedron,1998,vol. 54,p. 3817 - 3826.

15
[ 2350-43-8 ]
[ 4542-75-0 ]

References: [1]Macromolecules,2012,vol. 45,p. 1270 - 1280.
[2]Journal of the American Chemical Society,2003,vol. 125,p. 14972 - 14973.

16
[ 4542-75-0 ]
[ 104768-86-7 ]
[ 639825-43-7 ]

References: [1]Journal of the American Chemical Society,2003,vol. 125,p. 14972 - 14973.

17
[ 4542-75-0 ]
[ 609342-79-2 ]
[ 755017-79-9 ]

References: [1]Journal of the American Chemical Society,2004,vol. 126,p. 9196 - 9197.

18
[ 4542-75-0 ]
C₂₆H₃₈N₄O₇ [ No CAS ]

References: [1]Journal of the American Chemical Society,2004,vol. 126,p. 9196 - 9197.

19
[ 4542-75-0 ]
C₂₆H₃₀N₁₂O₇ [ No CAS ]

References: [1]Journal of the American Chemical Society,2004,vol. 126,p. 9196 - 9197.

20
[ 4542-75-0 ]
C₃₀H₂₈N₄O₄ [ No CAS ]

References: [1]Journal of the American Chemical Society,2003,vol. 125,p. 14972 - 14973.

21
[ 14387-30-5 ]
[ 4542-75-0 ]

References: [1]Journal of the American Chemical Society,2003,vol. 125,p. 14972 - 14973.

22
[ 4542-75-0 ]
bis[(tetrabutylammonium)-p-(methoxyphosphorylmethyl)phenyl] ether [ No CAS ]

References: [1]Chemistry - A European Journal,1997,vol. 3,p. 1537 - 1541.

23
[ 4542-75-0 ]
bis<4-(1-piperazinylmethyl)phenyl> ether [ No CAS ]

References: [1]Chemische Berichte,1994,vol. 127,p. 2267 - 2272.

24
[ 4542-75-0 ]
[ 160750-13-0 ]

References: [1]Chemische Berichte,1994,vol. 127,p. 2267 - 2272.

25
[ 4542-75-0 ]
[ 150587-68-1 ]

References: [1]Bulletin of the Chemical Society of Japan,1993,vol. 66,p. 1837 - 1839.

26
[ 4542-75-0 ]
[ 75208-04-7 ]

References: [1]Journal of Heterocyclic Chemistry,1980,vol. 17,p. 433 - 437.

27
[ 4542-75-0 ]
[ 75218-32-5 ]

References: [1]Journal of Heterocyclic Chemistry,1980,vol. 17,p. 433 - 437.

28
[ 4542-75-0 ]
[ 2362-18-7 ]

References: [1]Journal of the Chemical Society,1961,p. 1604 - 1610.

29
[ 4542-75-0 ]
[ 2215-89-6 ]