There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | ||||||
{[ item.p_purity ]} | {[ item.pr_size ]} | Inquiry |
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]} |
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price) ]} | {[ item.pr_usastock ]} | in stock Inquiry - | {[ item.pr_chinastock ]} | {[ item.pr_remark ]} in stock Inquiry - | Login | Inquiry |
Please Login or Create an Account to: See VIP prices and availability
CAS No. : | 4500-20-3 | MDL No. : | MFCD00456899 |
Formula : | C12H15NO | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | JTLAHVRPWDIEMU-UHFFFAOYSA-N |
M.W : | 189.25 | Pubchem ID : | 343882 |
Synonyms : |
|
Signal Word: | Danger | Class: | 4.1 |
Precautionary Statements: | P280-P210-P240-P264-P270-P301+P310-P330-P370+P378-P403+P233-P405-P501 | UN#: | 1325 |
Hazard Statements: | H228-H302-H317-H319-H341-H351 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96% | With polyphosphoric acid at 120℃; for 4h; | |
91% | With trifluorormethanesulfonic acid; 4 A molecular sieve; hydroxylamine hydrochloride; tetrabutylammonium perrhenate In nitromethane for 1h; Heating; | |
91% | With trifluorormethanesulfonic acid; hydroxylamine hydrochloride; tetrabutylammonium perrhenate In acetonitrile for 1h; Heating; |
With thionyl chloride In 1,4-dioxane at 20℃; for 0.5h; | ||
With thionyl chloride In 1,4-dioxane at 20℃; for 0.5h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With diborane In tetrahydrofuran for 4h; Ambient temperature; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine In dichloromethane; Petroleum ether at -40℃; | ||
With triethylamine In dichloromethane; Petroleum ether at -50℃; for 2h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With dicyclohexyl-carbodiimide In dichloromethane |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With hydroxylamine hydrochloride In ethanol at 50 - 60℃; for 0.25h; | |
97% | With hydroxylamine hydrochloride; sodium acetate In ethanol; water | 34.1 Preparation of (4-[1-((3S)-3-methylpiperazinyl)(1Z)-2-aza-2-(4-phenylcyclohexyl)vinyl]amino}phenyl)-N-[2-(2,4-dichlorophenyl)ethyl]carboxamide Step 1. Preparation of 1-(hydroxyimino)-4-phenylcyclohexane. A mixture of 4-phenylcyclohexanone (28.7 mmol), hydroxylamine hydrochloride (36.0 mmol), and sodium acetate (60.95 mmol) in ethanol and water was heated at 70° C. overnight. Ethanol was removed, and the residue was dissolved in water and ethyl acetate. The aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with brine, dried, and concentrated to give 1-(hydroxyimino)-4-phenylcyclohexane (97%). |
86% | With ammonium chloride In ethanol for 1h; Ambient temperature; |
85% | With hydroxylamine hydrochloride; silica gel; <i>tert</i>-butyl alcohol for 0.183333h; | |
74% | With hydroxylamine hydrochloride; sodium acetate In methanol; water at 60℃; | |
With sodium hydroxide; hydroxylamine hydrochloride In ethanol Heating; | ||
With pyridine; hydroxylamine hydrochloride In ethanol Heating; | ||
With hydroxylamine hydrochloride; sodium acetate In ethanol at 80℃; for 1h; | ||
106 g | With hydroxylamine hydrochloride; potassium hydroxide In ethanol; water for 2h; Reflux; | 1 Example 1.Preparation of 4-Phenylcyclohexanone oxime 1 4-phenylcyclohexanone (100 g, 0.57 mol)Hydroxylamine hydrochloride (100 g, 1.44 mol) and 50% aqueous potassium hydroxide solution (150 mL) were added to ethanol (50 mL).The resulting mixture was heated to reflux for 2 hours.After concentration under vacuum, water was added and stirred to give a white precipitate.After collecting the filter cake by filtration, the crude product of the target product is obtained.The crude product was recrystallized from ethanol to give 4-phenylcyclohexanone oxime 1 (106 g, 0.56 mol).It is a white solid. |
With hydroxylamine hydrochloride; sodium acetate In methanol; water at 20℃; for 1h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With peracetic acid; sodium dihydrogenphosphate; sulfuric acid; acetic acid; urea In acetonitrile Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With peracetic acid; sodium dihydrogenphosphate; sulfuric acid; acetic acid; urea In acetonitrile Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium In ethanol | ||
With ethanol; sodium |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
(i) H2, Raney-Ni, (ii) /BRN= 471389/; Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
(i) H2, Raney-Ni, (ii) /BRN= 471389/; Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine In diethyl ether at 0℃; for 1h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Rk.m.Na/EtOH; | ||
Rk.m.H2/PtO2; | ||
Hydr. m. Raney-Ni W4, 100grad, 100at -> 65percent cis-4-Phenyl-cyclohexylamin, 35percent trans-Isomeres; |
Δ, Na, abs. A. -> trans-4-Phenylcyclohexylamin; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | With aluminium trichloride; 1-benzyl-4-aza-1-azoniabicyclo[2.2.2]octane dichromate at 20℃; for 0.0119444h; | |
95% | With 1-benzyl-4-aza-1-azoniabicyclo[2.2.2]octane dichromate In dichloromethane for 0.0119444h; Irradiation; | |
95% | With aluminium trichloride; benzyltriphenylphosphonium chlorochromate In acetonitrile for 0.666667h; Heating; |
88% | Stage #1: 4-phenylcyclohexanone oxime With 4-cyano-3-fluorophenoxymethyl-Merrifield's resin; potassium <i>tert</i>-butylate In tetrahydrofuran; dimethyl sulfoxide at 55℃; for 4h; Stage #2: With trifluoroacetic acid In water at 55℃; for 1h; Further stages.; | |
85% | With bismuth(III) chloride; benzyltriphenylphosphonium peroxymonosulfate In acetonitrile for 0.666667h; Heating; | |
80% | With bismuth(III) chloride; benzyltriphenylphosphonium peroxymonosulfate In dichloromethane for 0.0666667h; microwave irradiation; | |
75% | With ammonium dichromate(VI); water; silica gel; zirconium(IV) chloride at 80℃; for 0.5h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium <i>tert</i>-butylate In N,N-dimethyl-formamide at 20℃; for 1h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium <i>tert</i>-butylate In N,N-dimethyl-formamide at 20℃; for 1h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
83% | Stage #1: 4-phenyl-cyclohexanol With chromium(VI) oxide; aluminum oxide; <i>tert</i>-butyl alcohol for 0.166667h; Stage #2: With hydroxylamine hydrochloride for 0.116667h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96% | With pyridine In ethanol at 20℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96% | With TEA In tetrahydrofuran at 0℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With iron In tetrahydrofuran at 20℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2; petroleum ether / 2 h / -50 °C 2: LiBH(s-Bu)3 / tetrahydrofuran / 2 h / Ambient temperature | ||
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2; petroleum ether / -40 °C 2: NaBH4 / tetrahydrofuran / Ambient temperature |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2; petroleum ether / 2 h / -50 °C 2: LiBH(s-Bu)3 / tetrahydrofuran / 2 h / Ambient temperature | ||
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2; petroleum ether / -40 °C 2: NaBH4 / tetrahydrofuran / Ambient temperature | ||
Multi-step reaction with 2 steps 1: Et3N / CH2Cl2; petroleum ether / -40 °C 2: 85 percent / LiBH(sec-C4H9)3 / tetrahydrofuran / Ambient temperature |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: DCC / CH2Cl2 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: B2H6 / tetrahydrofuran / 4 h / Ambient temperature 2: NaHCO3 aq. / diethyl ether / 0.25 h |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: (i) H2, Raney-Ni, (ii) /BRN= 471389/ 2: KOH / aq. ethanol / 180 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: Na / ethanol 2: Py |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: (i) H2, Raney-Ni, (ii) /BRN= 471389/ 2: KOH / aq. ethanol / 180 °C 3: Py |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: Na / ethanol 2: benzene |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: (i) H2, Raney-Ni, (ii) /BRN= 471389/ 2: KOH / aq. ethanol / 180 °C 3: benzene |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: Na / ethanol 2: Py 3: NaOH / aq. ethanol / Heating |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: (i) H2, Raney-Ni, (ii) /BRN= 471389/ 2: KOH / aq. ethanol / 180 °C 3: Py / benzene 4: NaOH / aq. ethanol / Heating |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: Na / ethanol 2: benzene |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: (i) H2, Raney-Ni, (ii) /BRN= 471389/ 2: KOH / aq. ethanol / 180 °C 3: benzene |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: Na / ethanol 2: benzene |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: (i) H2, Raney-Ni, (ii) /BRN= 471389/ 2: KOH / aq. ethanol / 180 °C 3: Py / benzene |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: Na / ethanol 2: Py |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: (i) H2, Raney-Ni, (ii) /BRN= 471389/ 2: KOH / aq. ethanol / 180 °C 3: Py / benzene |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With hydrogenchloride In 1,4-dioxane; methanol; ethanol | 34.2 Preparation of (4-[1-((3S)-3-methylpiperazinyl)(1Z)-2-aza-2-(4-phenylcyclohexyl)vinyl]amino}phenyl)-N-[2-(2,4-dichlorophenyl)ethyl]carboxamide Step 2. Preparation of 4-phenylcyclohexylamine. A mixture of 1-(hydroxyimino)-4-phenylcyclohexane (17.4 mmol) and Raney Nickel (300 mg) in ethanol was hydrogenated (90 psi) at 50° C. for 40 hours. The mixture was filtered through a pad of Celite, washed with MeOH, and concentrated. The residue was dissolved in MeOH, treated with HCl (4 N in dioxane, 20 mmol), and concentrated to give 4-phenylcyclohexylamine hydrochloride (100%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydroxylamine hydrochloride In ethanol | 77 Example 77 Example 77 4-phenylcyclohexanone oxime A mixture of 8.08 g. of 4-phenylcyclohexanone (obtained as in Example 76), 8 g. of hydroxylamine hydrochloride and 16 ml. of 45% aqueous potassium hydroxide solution in 100 ml. of ethanol, is heated at reflux for about 4 hours. The mixture is concentrated under vacuum and then diluted with water. The precipitated solid is collected on a filter and recrystallized from Skellysolve B to give 7.5 g. of 4-phenylcyclohexanone oxime having a melting point of 110° to 112° C. Anal. Calcd. for C12 H15 NO: C, 76.15; H, 7.99; N, 7.40. Found: C, 75.91; H, 8.04; N, 7.24. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
64% | Stage #1: 4-phenylcyclohexanone oxime; acetic anhydride With triethylphosphine In toluene for 22h; Heating; Stage #2: With potassium carbonate In methanol at 20℃; for 0.5h; Further stages.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96% | In toluene Inert atmosphere; Reflux; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | With sodium hydrogensulfate monohydrate; molybdenum(V) chloride; sodium cyanoborohydride In ethanol for 0.7h; Reflux; | |
92% | With sodium tetrahydroborate at 20℃; for 0.0333333h; neat (no solvent, solid phase); | |
85% | With iron oxide; zirconium(IV) chloride; sodium cyanoborohydride In neat (no solvent) at 20℃; for 0.0833333h; | A typical procedure for solvent-free reductionof benzaldehyde oxime to benzylamine with NaBH3CN/ZrCl4/nano Fe3O4 system General procedure: A mixture of benzaldehyde oxime (0.121 g, 1 mmol) and nano Fe3O4 (0.046 g, 0.2 mmol) (nano particle size≈70 nm) was ground in a porcelain mortar. ZrCl4 (0.233 g,1 mmol) was then added and grinding the mixture was continued for a moment at room temperature. The mortar was heated in an oil bath until the temperature of reaction mixture reaches 75-80 °C. NaBH3CN (0.314 g, 5 mmol) wasthen added portion wisely and the mixture was ground for15 min at 75-80 °C. After completion of the reaction, H2O(5 mL) was added and the mixture was stirred for 5 min. The mixture was extracted with EtOAc (2 × 5 mL) and then dried over anhydrous Na2SO4. Evaporation of the solvent affords the pure liquid benzylamine in 93 % yield (0.1 g, Table 2, entry 1). |
85% | With zirconium(IV) chloride; sodium cyanoborohydride In neat (no solvent) at 20℃; for 0.0833333h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 6 steps 1: thionyl chloride / 1,4-dioxane / 0.5 h / 20 °C 2: sodium hydroxide / ethanol / 12 h / 120 °C / Sealed tube 3: thionyl chloride / 0.5 h / 0 °C 4: triethylamine / dichloromethane / 0.5 h / 0 °C 5: sodium hydroxide / methanol / 0.5 h 6: dmap; copper(II) trifluoroacetate; iodosylbenzene / dichloromethane / 4 h / 100 °C / Sealed tube |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: thionyl chloride / 1,4-dioxane / 0.5 h / 20 °C 2: sodium hydroxide / ethanol / 12 h / 120 °C / Sealed tube |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: thionyl chloride / 1,4-dioxane / 0.5 h / 20 °C 2: sodium hydroxide / ethanol / 12 h / 120 °C / Sealed tube 3: thionyl chloride / 0.5 h / 0 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: thionyl chloride / 1,4-dioxane / 0.5 h / 20 °C 2: sodium hydroxide / ethanol / 12 h / 120 °C / Sealed tube 3: thionyl chloride / 0.5 h / 0 °C 4: triethylamine / dichloromethane / 0.5 h / 0 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 5 steps 1: thionyl chloride / 1,4-dioxane / 0.5 h / 20 °C 2: sodium hydroxide / ethanol / 12 h / 120 °C / Sealed tube 3: thionyl chloride / 0.5 h / 0 °C 4: triethylamine / dichloromethane / 0.5 h / 0 °C 5: sodium hydroxide / methanol / 0.5 h |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: thionyl chloride / 1,4-dioxane / 0.5 h / 20 °C 2: triethylamine / dichloromethane / 13 h / 0 - 20 °C 3: 2,5-di-tert-butyl-p-benzoquinone; palladium(II) trifluoroacetate; racemic methyl phenyl sulfoxide; zinc(II) trifluoroacetate; di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / dichloromethane; 1,4-dioxane / 24 h / 20 °C / Inert atmosphere; Sealed tube |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: thionyl chloride / 1,4-dioxane / 0.5 h / 20 °C 2: triethylamine / dichloromethane / 13 h / 0 - 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
93% | With Pd(OH)x/LDH In N,N-dimethyl acetamide at 130℃; for 3h; Schlenk technique; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
18 % de | With sodium tetrahydroborate; molybdenum(VI) oxide In methanol at 0℃; for 2h; Overall yield = 67 mg; |
[ 914934-36-4 ]
2-Phenylcyclopropanecarbaldehyde oxime
Similarity: 0.86
[ 1788-31-4 ]
1,3-Diphenylpropan-2-one oxime
Similarity: 0.83
[ 914934-36-4 ]
2-Phenylcyclopropanecarbaldehyde oxime
Similarity: 0.86
[ 1788-31-4 ]
1,3-Diphenylpropan-2-one oxime
Similarity: 0.83