448968-52-3|5-(Bromomethyl)-2-nitropyridine| Ambeed

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Quality Control of [ 448968-52-3 ] Purity: 95% SDS Specification

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Product Details of [ 448968-52-3 ]

CAS No. :	448968-52-3
Formula :	C₆H₅BrN₂O₂
M.W :	217.02
SMILES Code :	O=[N+](C1=NC=C(CBr)C=C1)[O-]
MDL No. :	MFCD14584503
InChI Key :	RWMMMFKJDQNPTR-UHFFFAOYSA-N
Pubchem ID :	58122257

Safety of [ 448968-52-3 ]

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H302-H314
Precautionary Statements:	P501-P260-P270-P264-P280-P303+P361+P353-P301+P330+P331-P363-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P405
Class:	8
UN#:	3261
Packing Group:	Ⅱ

Application In Synthesis of [ 448968-52-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 448968-52-3 ]

[ 448968-52-3 ] Synthesis Path-Downstream 1~18

1
[ 448967-00-8 ]
[ 448968-52-3 ]
[ 448968-53-4 ]

Yield	Reaction Conditions	Operation in experiment
		1-Methyl-3-(6-nitro-pyridin-3-ylmethyl)-2,4-dioxo-1,2,3,4-tetrahydro-thieno[2,3-d]pyrimidine-6-carboxylic acid 4-methoxy-benzylamide Made by the procedure of Example 217 from 1-methyl-1,2,3,4-tetrahydro-thieno[2,3-d]pyrimidine-6-carboxylic acid 4-methoxy-benzylamide and <strong>[448968-52-3]5-(bromomethyl)-2-nitropyridine</strong>; mp 238-241 C.

References: [1]Patent: US2003/4172,2003,A1 .

2
[ 448967-04-2 ]
[ 448968-52-3 ]
[ 448968-54-5 ]

Yield	Reaction Conditions	Operation in experiment
		1-Methyl-3-(6-nitro-pyridin-3-ylmethyl)-2,4-dioxo-1,2,3,4-tetrahydro-thieno[2,3-d]pyrimidine-6-carboxylic acid (2-methoxy-pyridin-4-ylmethyl)-amide Made by the procedure of Example 217 from 1-methyl-2,4-dioxo-1,2,3,4-tetrahydro-thieno[2,3-d]pyrimidine-6-carboxylic acid (2-methoxy-pyridin-4-ylmethyl)-amide and <strong>[448968-52-3]5-(bromomethyl)-2-nitropyridine</strong>; mp 200-207 C.

References: [1]Patent: US2003/4172,2003,A1 .

3
[ 448968-52-3 ]
[ 448967-03-1 ]
[ 448968-51-2 ]

Yield	Reaction Conditions	Operation in experiment
		1-Methyl-3-(6-nitro-pyridin-3-ylmethyl)-2,4-dioxo-1,2,3,4-tetrahydro-thieno[2,3-d]pyrimidine-6-carboxylic acid 3-methoxy-benzylamide Made by the procedure of Example 217 from 1-methyl-1,2,3,4-tetrahydro-thieno[2,3-d]pyrimidine-6-carboxylic acid 3-methoxy-benzylamide and <strong>[448968-52-3]5-(bromomethyl)-2-nitropyridine</strong>; mp 213-215 C.

References: [1]Patent: US2003/4172,2003,A1 .

4
[ 448968-52-3 ]
[ 762-04-9 ]
diethyl [(6-nitropyridin-3-yl)methyl]phosphonate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
55%		Diethyl [(6-nitropyridin-3-yl)methyl]phosphonate (13a).To a suspensionof NaH (60% dispersion in mineral oil, 32.0 mg, 800 mmol) inTHF (2.0 mL) was added diethyl phosphite (118 mL, 913 mmol) at 0 C, and the mixture was stirred at 65 C for 1h. Aftercooled to 0 C, to the mixture was added 12a3 (86.8 mg, 400 mmol), and the mixture was stirred for overnight at the ambienttemperature. The solvent was removed under reducedpressure and the resulting residue was diluted with EtOAc. Then, the organicsolution was washed with H2O and brine, dried over Na2SO4,and concentrated under reduced pressure. The residue was purified bysilica-gel column chromatography to obtain 13a (60.0 mg, 219 mmol, 55%) as a dark orange solid. 1HNMR (400 MHz, CDCl3) d 1.26 (t, 6H, J = 7.3 Hz), 3.25 (d, 2H, 2JH-P = 22.2 Hz), 4.03-4.11 (m, 4H), 8.00 (td,1H, J = 2.2, 8.4 Hz), 8.22 (d, 1H, J =8.4 Hz), 8.51 (t, 1H, J = 2.2 Hz).

References: [1]Bioorganic and Medicinal Chemistry Letters,2015,vol. 25,p. 3676 - 3680.

5
[ 448968-52-3 ]
ethyl(N-methylphthalimid-5-yl)[(6-nitropyridin-3-yl)methyl]phosphonate [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2015,vol. 25,p. 3676 - 3680.

6
[ 448968-52-3 ]
ethyl(N-methylphthalimid-5-yl)[(6-aminopyridin-3-yl)methyl]phosphonate hydrochloride [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2015,vol. 25,p. 3676 - 3680.

7
[ 1074-38-0 ]
[ 448968-52-3 ]

References: [1]Journal of the American Chemical Society,2017,vol. 139,p. 4611 - 4614.

8
[ 1603-41-4 ]
[ 448968-52-3 ]

References: [1]Journal of the American Chemical Society,2017,vol. 139,p. 4611 - 4614.

9
[ 448968-52-3 ]
methyl (S)-2-amino-3-(6-nitropyridin-3-yl)propionate [ No CAS ]

References: [1]Journal of the American Chemical Society,2017,vol. 139,p. 4611 - 4614.

10
[ 448968-52-3 ]
methyl 3-(6-aminopyridin-3-yl)-(S)-2-((4,5-dimethoxy-2-nitrobenzyloxy)carbonylamino)propionate [ No CAS ]