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Chemical Structure| 446880-80-4 Chemical Structure| 446880-80-4

Structure of 446880-80-4

Chemical Structure| 446880-80-4

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Product Details of [ 446880-80-4 ]

CAS No. :446880-80-4
Formula : C13H11BrN2O
M.W : 291.14
SMILES Code : CC1=CC=CC(C(CC2=CC(Br)=NC=C2)=O)=N1
MDL No. :MFCD11849148

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Application In Synthesis of [ 446880-80-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 446880-80-4 ]

[ 446880-80-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 568577-88-8 ]
  • [ 446880-80-4 ]
  • [ 656239-44-0 ]
YieldReaction ConditionsOperation in experiment
98% With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,2-dimethoxyethane; for 18h;Heating / reflux; To a solution of intermediate 15 (3g, 10.3 [MMOL)] in DME (100 mL) was added tetrakis [(TRIPHENYLPHOSPHINE) PALLADIUM (0)] (1.2g, 10% mol), intermediate 9 (3.86g, 13.4 [MMOL)] and [NA2CO3] [(2M,] 10.3 ml) and the mixture was heated under reflux for 18 hours. The cooled mixture was poured into water and extracted with [CH2CI2.] The organic phase was washed with water, dried over [NA2SO4] and filtered. Evaporation of the solvent in vacuo gave a crude oil which was purified by chromatography on silica gel (CH2CI2/MeOH, 97: 3) to give the title compound (3.77g, 98%); [APCI MS} [M/Z 374.] 13 [(MH+).]
 

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