4468-57-9|2-(2,3-Dimethoxyphenyl)acetonitrile| Ambeed

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Quality Control of [ 4468-57-9 ] Purity: 98% SDS Specification

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NMR

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Product Details of [ 4468-57-9 ]

CAS No. :	4468-57-9
Formula :	C₁₀H₁₁NO₂
M.W :	177.20
SMILES Code :	N#CCC1=CC=CC(OC)=C1OC
MDL No. :	MFCD00016387
InChI Key :	VAOKGCHIOACZHR-UHFFFAOYSA-N
Pubchem ID :	138263

Safety of [ 4468-57-9 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 4468-57-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 4468-57-9 ]

[ 4468-57-9 ] Synthesis Path-Downstream 1~35

1
[ 6280-87-1 ]
[ 4468-57-9 ]
[ 872306-79-1 ]

References: [1]Journal of the American Chemical Society,1947,vol. 69,p. 2929,2930.
Journal of the American Chemical Society,1948,vol. 70,p. 2072,2073.

2
[ 4468-57-9 ]
[ 3213-29-4 ]

References: [1]Bulletin de la Societe Chimique de France,1956,p. 1830,1832.
[2]Journal of the American Chemical Society,1964,vol. 86,p. 4959 - 4963.

3
[ 4468-57-9 ]
[ 90-53-9 ]

Yield	Reaction Conditions	Operation in experiment
88%	With water; sodium hydroxide; at 110℃; for 10.5h;	<strong>[4468-57-9]2,3-dimethoxyphenylacetonitrile</strong> (1120 mg, 6.3 mmol) and sodium hydroxide (1190 mg, 48 mmol) are dissolved in water (30 mL) and the mixture is stirred at 110 C. for 10.5 hours. The reaction solution is washed with diethyl ether, hydrochloric acid is added to the aqueous layer, and the mixture is extracted with ethyl acetate. The solvent is distilled off under reduced pressure and pale yellow liquid (1091 mg, 5.6 mmol) is obtained in 88% yield.

References: [1]Helvetica Chimica Acta,2003,vol. 86,p. 343 - 360.
[2]Patent: US2020/131193,2020,A1 .Location in patent: Paragraph 0196-0197.
[3]Canadian Journal of Chemistry,1982,vol. 60,p. 2678 - 2686.
[4]Journal of Organic Chemistry,1950,vol. 15,p. 548,549.
Organic Syntheses,1963,vol. Coll. Vol. IV,p. 760,762.
[5]Annales Pharmaceutiques Francaises,1949,vol. 7,p. 733,741.

4
[ 4468-57-9 ]
[ 91640-60-7 ]

References: [1]Journal of the American Chemical Society,1948,vol. 70,p. 2945,2948.
[2]Helvetica Chimica Acta,1964,vol. 47,p. 1340 - 1349.

5
[ 4468-57-9 ]
[ 5663-55-8 ]

References: [1]Journal of Organic Chemistry,1950,vol. 15,p. 548,549.
Organic Syntheses,1963,vol. Coll. Vol. IV,p. 760,762.

6
[ 4468-57-9 ]
[ 124-40-3 ]
[ 3494-01-7 ]

References: [1]Journal of the American Chemical Society,1938,vol. 60,p. 1789,1790.

7
[ 4468-57-9 ]
[ 107-99-3 ]
[ 231289-61-5 ]

References: [1]Tetrahedron Letters,1999,vol. 40,p. 3905 - 3908.
[2]Helvetica Chimica Acta,1949,vol. 32,p. 2489,2497.

8
[ 4468-57-9 ]
[ 107-13-1 ]
[ 76679-00-0 ]

References: [1]Chemical and Pharmaceutical Bulletin,1980,vol. 28,p. 2862 - 2867.
[2]Journal of the American Chemical Society,1948,vol. 70,p. 2945,2948.

9
[ 4468-57-9 ]
[ 51-75-2 ]
[ 408510-36-1 ]

References: [1]Journal of the Chemical Society,1946,p. 958,962.

10
[ 151-50-8 ]
[ 3893-01-4 ]
[ 4468-57-9 ]

References: [1]Helvetica Chimica Acta,2003,vol. 86,p. 343 - 360.
[2]Chemical and Pharmaceutical Bulletin,1980,vol. 28,p. 2862 - 2867.
[3]Annales Pharmaceutiques Francaises,1949,vol. 7,p. 733,741.
[4]Journal of the American Chemical Society,1964,vol. 86,p. 4959 - 4963.

11
[ 4468-57-9 ]
[ 17542-47-1 ]
4-(benzyl-methyl-amino)-2-(2,3-dimethoxy-phenyl)-butyronitrile [ No CAS ]

References: [1]Helvetica Chimica Acta,1949,vol. 32,p. 2489,2497.

12
[ 4468-57-9 ]
[ 74-88-4 ]
[ 62115-73-5 ]

References: [1]Journal of the American Chemical Society,1951,vol. 73,p. 4827.

13
[ 4468-57-9 ]
[ 143784-37-6 ]

References: [1]Tetrahedron Letters,1992,vol. 33,p. 4205 - 4208.

14
[ 4468-57-9 ]
[ 100-52-7 ]
[ 80472-43-1 ]

References: [1]Synthesis,1981,p. 913 - 915.

15
[ 4468-57-9 ]
[ 100-47-0 ]
N-(5-Phenyl-[1,3]dioxolo[4,5-g]isoquinolin-7-yl)-benzamidine; hydrochloride [ No CAS ]
2-(3,4-Dimethoxy-phenyl)-N-(5,6-dimethoxy-1-phenyl-isoquinolin-3-yl)-acetamidine; hydrochloride [ No CAS ]

References: [1]Tetrahedron Letters,1992,vol. 33,p. 4205 - 4208.

16
[ 4468-57-9 ]
[ 292638-85-8 ]
[ 26709-78-4 ]

References: [1]Chemical and pharmaceutical bulletin,1986,vol. 34,p. 2443 - 2447.
[2]Journal of Organic Chemistry,1971,vol. 36,p. 111 - 117.

17
[ 3893-01-4 ]
[ 4468-57-9 ]

References: [1]Canadian Journal of Chemistry,1982,vol. 60,p. 2678 - 2686.

18
[ 4468-57-9 ]
[ 105-58-8 ]
[ 83751-77-3 ]

References: [1]Helvetica Chimica Acta,1964,vol. 47,p. 1340 - 1349.

19
[ 4468-57-9 ]
N-[1-(2,3-Dimethoxy-benzyl)-5,6-dimethoxy-isoquinolin-3-yl]-2-(2,3-dimethoxy-phenyl)-acetamidine [ No CAS ]

References: [1]Russian Journal of Organic Chemistry,1994,vol. 30,p. 1867 - 1875.
Zhurnal Organicheskoi Khimii,1994,vol. 30,p. 1782 - 1790.

20
2-phenyl-4-<2.3-dimethoxy-benzyliden>-Δ²-oxazolinone-(5) [ No CAS ]
[ 4468-57-9 ]

References: [1]Journal of the Chemical Society,1944,p. 261,264.

21
[ 768-66-1 ]
[ 92-39-7 ]
[ 4468-57-9 ]
2-(2,2,6,6-tetramethylpiperidin-1-yl)-10H-phenothiazine [ No CAS ]
2-([3,4-dimethoxyphenyl]methyl)-10H-phenothiazine-1-carbonitrile [ No CAS ]

References: [1]Heterocycles,2000,vol. 53,p. 373 - 380.

22
[ 5653-67-8 ]
[ 4468-57-9 ]

References: [1]Helvetica Chimica Acta,2003,vol. 86,p. 343 - 360.
[2]Canadian Journal of Chemistry,1982,vol. 60,p. 2678 - 2686.
[3]Journal of the American Chemical Society,1964,vol. 86,p. 4959 - 4963.
[4]Beilstein Journal of Organic Chemistry,2014,vol. 10,p. 1919 - 1932.
[5]Patent: US2020/131193,2020,A1 .

23
[ 4468-57-9 ]
[ 27466-90-6 ]