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Chemical Structure| 445378-38-1 Chemical Structure| 445378-38-1

Structure of 445378-38-1

Chemical Structure| 445378-38-1

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Product Details of [ 445378-38-1 ]

CAS No. :445378-38-1
Formula : C5H8O2
M.W : 100.12
SMILES Code : OC1C=CCOC1
MDL No. :MFCD24394456

Safety of [ 445378-38-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 445378-38-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 445378-38-1 ]

[ 445378-38-1 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 445378-38-1 ]
  • [ 98166-23-5 ]
YieldReaction ConditionsOperation in experiment
97% With Dess-Martin periodane In dichloromethane at 0 - 20℃; for 5 h; 3,6-Dihydro-2H-pyran-3-ol (2.44 g,24.37 mmol) was dissolved in DCM (100 mL) and cooled to 0 °C before slowly adding Dess-Martin periodinane (10.34 g, 24.37 mmol). The reaction was allowed to slowly warm to room temperature over 5 h. The reaction was then filtered through celite. After- 79 -ATI-2514175vl concentrating the filtrate, the crude material was purified on a 100G SNAP Biotage column (0-80percent ethyl acetate in hexane) to give 2H-pyran-3(6H)-one (2.33 g, 23.75 mmol, 97 percent yield) as a colorless oil; 1H NMR (400 MHz, CDC13) δ ppm 7.07 - 7.17 (m, 1H), 6.15 - 6.25 (m, 1H), 4.39 (t, J=2.54 Hz, 2H), 4.19 (s, 2H).
References: [1] Patent: WO2012/145569, 2012, A1, . Location in patent: Page/Page column 79; 80.
[2] Angewandte Chemie - International Edition, 2005, vol. 44, # 33, p. 5306 - 5310.
[3] Synlett, 2006, # 4, p. 621 - 623.
[4] Patent: WO2014/134566, 2014, A2, . Location in patent: Paragraph 0547.
 

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