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Chemical Structure| 442199-19-1 Chemical Structure| 442199-19-1

Structure of 442199-19-1

Chemical Structure| 442199-19-1

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Product Details of [ 442199-19-1 ]

CAS No. :442199-19-1
Formula : C14H20ClN3O3
M.W : 313.78
SMILES Code : O=C(N1CCC(OC2=NC=NC(Cl)=C2)CC1)OC(C)(C)C
MDL No. :MFCD09607595

Safety of [ 442199-19-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 442199-19-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 442199-19-1 ]

[ 442199-19-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 442199-19-1 ]
  • [ 387350-92-7 ]
  • [ 1145657-02-8 ]
YieldReaction ConditionsOperation in experiment
40% To a suspension of sodium hydride (0.25 g, 2 eq) in 10 mL of DMF, was added 5- methanesulfonyl-2,3-dihydro-lH-indole (0.63 g , 1 eq). The mixture was stirred at room temperature for 10 minutes then 3a (1 g, 3.19 mmol) was added. The resulting mixture was heated up to 80 0C for 18h. The reaction mixture was then allowed to cool down to room temperature and brine (200 mL) was added. The solution was extracted with DCM twice (200 mL then 50 mL). The combined extracts were washed with brine (2 x 50 mL), dried over magnesium sulfate and filtered. The solvent was removed under vacuum to give an oil which was purified by column chromatography (elution with 10-100% ethyl acetate and 0.1% TEA in hexanes) to give 0.61 g of 4a (40% yield), LCMS 475.2 (MH+).
 

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