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Chemical Structure| 4381-25-3 Chemical Structure| 4381-25-3
Chemical Structure| 4381-25-3

(S-Methylsulfonimidoyl)benzene

CAS No.: 4381-25-3

4.5 *For Research Use Only !

Cat. No.: A989431 Purity: 98%

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Product Details of [ 4381-25-3 ]

CAS No. :4381-25-3
Formula : C7H9NOS
M.W : 155.22
SMILES Code : N=S(C1=CC=CC=C1)(C)=O
MDL No. :MFCD00051933

Safety of [ 4381-25-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P264-P270-P301+P312-P330-P501

Application In Synthesis of [ 4381-25-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4381-25-3 ]

[ 4381-25-3 ] Synthesis Path-Downstream   1~9

  • 1
  • [ 62674-71-9 ]
  • [ 4381-25-3 ]
  • N-(6-methyl-2-pyridinyl)-S-methyl-S-phenylsulfoximine [ No CAS ]
  • 2
  • [ 769-26-6 ]
  • [ 4381-25-3 ]
  • N-(2,4,6-trimethyl-phenylethynyl)-S,S-methylphenylsulfoximine [ No CAS ]
  • 3
  • [ 32340-38-8 ]
  • [ 4381-25-3 ]
  • [ 1498210-68-6 ]
  • 4
  • [ 4381-25-3 ]
  • [ 31680-08-7 ]
  • C15H14N2O5S [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; In hexane; water; for 12h;Inert atmosphere; Reflux; General procedure: To a flame-dried 10 mL Schlenk tube under N2 was added NH-sulfoximine 1 (0.3 mmol), aldehyde 3 (4.0 equiv), and TBAI (20 mol%), followed by n-hexane (1 mL). TBHP (2.0 equiv, 70% aqueous solution) was added after the starting materials were dissolved. The reaction mixture was then heated to reflux. After completion, the reaction was cooled to room temperature and quenched with saturated Na2S2O3, extracted by EA. The organic layer was washed by saturated brine, dried over anhydrous sodium sulfate. After the mixture was filtered and evaporated, the residue was purified by flash column chromatography to afford the desired N-acylsulfoximine 3.
  • 5
  • [ 6563-13-9 ]
  • [ 4381-25-3 ]
  • 6-methoxy-2-[(methyl(oxo)(phenyl)-λ6-sulfanylidene)amino]quinoline 1-oxide [ No CAS ]
  • 6
  • [ 4381-25-3 ]
  • [ 175205-81-9 ]
  • (S)-methyl(phenyl)((4-(trifluoromethyl)pyridin-2-yl)imino)-λ6-sulfanone [ No CAS ]
  • 7
  • [ 4381-25-3 ]
  • [ 175205-81-9 ]
  • methyl(phenyl)((4-(trifluoromethyl)pyridin-2-yl)imino)-λ6-sulfanone [ No CAS ]
  • 8
  • [ 62830-55-1 ]
  • [ 4381-25-3 ]
  • N-(4-iodophenyl)-S-methyl-S-phenylsulfoximine [ No CAS ]
YieldReaction ConditionsOperation in experiment
86% With oxygen; potassium acetate; copper(I) bromide; In acetone; at 20℃; for 12h;Schlenk technique; General procedure: Under the oxygen atmosphere, a Schlenk tube (35 mL) equipped with a magnetic bar was loaded with the NH-sulfoximine 1 (0.5 mmo), arylhydrazine chloride (2.0 equiv.), Cu(OAc)2 (20 mol%), KOAc (2.0 equiv.) in dry acetone (4.0 mL). Then the mixture was allowed to stir at room temperature for 12 h. After the completion of the reaction, as monitored by TLC analysis, the mixture was filtered through a short celite pad and washed with dichloromethane (15 mL 3). The filtrate was concentrated, and the oily crude product was puried by column chromatography using silica gel (200-300 mesh) as stationary phase and a mixture of n-hexaneand ethyl acetate (2:1) as eluent to give the corresponding arylated products 3 or 5 (Rf = ca.0.3 otherwise noted).
  • 9
  • [ 2243-58-5 ]
  • [ 4381-25-3 ]
  • N-(2-naphthyl)-S-phenyl-S-methylsulfoximine [ No CAS ]
YieldReaction ConditionsOperation in experiment
88% With oxygen; potassium acetate; copper(I) bromide; In acetone; at 20℃; for 12h;Schlenk technique; General procedure: Under the oxygen atmosphere, a Schlenk tube (35 mL) equipped with a magnetic bar was loaded with the NH-sulfoximine 1 (0.5 mmo), arylhydrazine chloride (2.0 equiv.), Cu(OAc)2 (20 mol%), KOAc (2.0 equiv.) in dry acetone (4.0 mL). Then the mixture was allowed to stir at room temperature for 12 h. After the completion of the reaction, as monitored by TLC analysis, the mixture was filtered through a short celite pad and washed with dichloromethane (15 mL 3). The filtrate was concentrated, and the oily crude product was puried by column chromatography using silica gel (200-300 mesh) as stationary phase and a mixture of n-hexaneand ethyl acetate (2:1) as eluent to give the corresponding arylated products 3 or 5 (Rf = ca.0.3 otherwise noted).
 

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