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Chemical Structure| 4352-30-1 Chemical Structure| 4352-30-1

Structure of 4352-30-1

Chemical Structure| 4352-30-1

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Product Details of [ 4352-30-1 ]

CAS No. :4352-30-1
Formula : C7H13ClO2S
M.W : 196.69
SMILES Code : O=S(CC1CCCCC1)(Cl)=O
MDL No. :MFCD03452748
InChI Key :BNZZPMGQCWZOPS-UHFFFAOYSA-N
Pubchem ID :3871475

Safety of [ 4352-30-1 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3265
Packing Group:

Application In Synthesis of [ 4352-30-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4352-30-1 ]

[ 4352-30-1 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 4352-30-1 ]
  • [ 18650-39-0 ]
  • [ 242459-56-9 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In dichloromethane; PREPARATION 25 Methyl (2S)-1-[(Cyclohexylmethyl)sulfonyl]-2-piperidinecarboxylate Triethylamine (22.15 ml) was added to a solution of (2S)-2-(methoxycarbonyl)piperidine hydrochloride (10 g) [see Preparation 24] and cyclohexylmethanesulfonyl chloride (16.42 g) [King. J. F. et al,. J. Am. Chem. Soc., 1992, 114(5), 1743-9] in dichloromethane (100 ml). The reaction mixture was stirred for 18 hours after which time the solvent was removed under reduced pressure and the residue diluted with ethyl acetate. The organic layer was washed with water, brine, dried over magnesium sulphate and the solvent was removed under reduced pressure. The crude product was purified by column chromatography on silica gel eluding with a solvent gradient of 95:5 changing to 80:20, by volume, hexane:ethyl acetate to afford methyl (2S)-1-[(cyclohexylmethyl)sulfonyl]-2-piperidinecarboxylate (11.9 g) as a white solid. 1H-NMR (CDCl3) delta: 4.70 (1H, d), 3.75 (3H, s), 3.70 (1H, d), 3.20 (1H, t), 2.80 (2H, d), 2.20 (1H, d), 2.00-1.00 (16H, m).
  • 2
  • [ 61477-39-2 ]
  • [ 4352-30-1 ]
  • C18H35NO5S2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In tetrahydrofuran; at 0 - 20℃; for 16h; To a solution of <strong>[61477-39-2](3S)-3-aminobutan-1-ol</strong> (200 mg, 2.24 mmol) and triethylamine (0.79 mL, 5.61 mmol) in tetrahydrofuran (7 mL) at 0 °C was slowly added cyclohexylmethanesulfonyl chloride (1.0 g, 5.16 mmol) and the reaction was stirred at room temperature for 16 hours. Methyl tert-butyl ether (20 mL) was then added to precipitate triethylamine hydrochloride and the salt was removed by filtration. The filtrate was then concentrated to give crude bis-sulfonylated intermediate.
  • 3
  • [ 61477-39-2 ]
  • [ 4352-30-1 ]
  • C18H35NO5S2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In tetrahydrofuran; at 20℃; for 16h; To a solution of <strong>[61477-39-2](3S)-3-aminobutan-1-ol</strong> (200 mg, 2.24 mmol) and triethylamine (0.79 mL, 5.61 mmol) in tetrahydrofuran (7 mL) at 0° C. was slowly added cyclohexylmethanesulfonyl chloride (1.0 g, 5.16 mmol) and the reaction was stirred at room temperature for 16 hours. Methyl tert-butyl ether (20 mL) was then added to precipitate triethylamine hydrochloride and the salt was removed by filtration. The filtrate was then concentrated to give crude bis-sulfonylated intermediate
 

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