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Chemical Structure| 433-97-6 Chemical Structure| 433-97-6

Structure of 433-97-6

Chemical Structure| 433-97-6

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Product Details of [ 433-97-6 ]

CAS No. :433-97-6
Formula : C8H5F3O2
M.W : 190.12
SMILES Code : O=C(O)C1=CC=CC=C1C(F)(F)F
MDL No. :MFCD00002476
InChI Key :FBRJYBGLCHWYOE-UHFFFAOYSA-N
Pubchem ID :9899

Safety of [ 433-97-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 433-97-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 433-97-6 ]

[ 433-97-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 17672-21-8 ]
  • [ 433-97-6 ]
  • methyl 2-(2-(trifluoromethyl)phenyl)benzo[d]oxazole-4-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
31% With polyphosphoric acid; at 140℃; for 3h; Step 1) Preparation of methyl 2-(2-(trifluoromethyl)phenyl)benzo[d]oxazole-4- carboxylate (6):Methyl 2-amino-3-hydroxybenzoate (4; 0.5 g, 3 mmol) and 2- (trifluoromethyl)benzoic acid (5; 0.57 g, 3 mmol) was taken up in 20 mL of PPA. The reaction mixture was stirred at 140 0C for 3 h. The reaction mixture was cooled to about 100 0C and diluted carefully with 50 mL of water. The resulting solids were collected by filtration and dried. Purification by chromatography afforded methyl 2-(2-(trifluoromethyl)phenyl)benzo[d]oxazole-4-carboxylate 6 (0.3 g, 31%). MS(ESI) calcd for CI6HI0F3NO3: 321.04; found: 322 [M+H].
  • 2
  • [ 17408-16-1 ]
  • [ 433-97-6 ]
  • C17H12F3NO5 [ No CAS ]
 

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