Home Cart Sign in  
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 43064-12-6 Chemical Structure| 43064-12-6

Structure of 43064-12-6

Chemical Structure| 43064-12-6

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 43064-12-6 ]

CAS No. :43064-12-6
Formula : C11H14ClN
M.W : 195.69
SMILES Code : [H]Cl.C1(C2=CC=CC=C2)=CCNCC1
MDL No. :MFCD00012752
InChI Key :POGWXTJNUCZEPR-UHFFFAOYSA-N
Pubchem ID :2723860

Safety of [ 43064-12-6 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H311-H331-H351
Precautionary Statements:P261-P280-P301+P310-P311
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 43064-12-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 43064-12-6 ]

[ 43064-12-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 43064-12-6 ]
  • [ 10272-49-8 ]
YieldReaction ConditionsOperation in experiment
99% carbon palladium; In methanol; Reference Example 8 4-Phenylpiperidine Hydrochloride 1,2,3,6-Tetrahydro-4-phenylpyridine hydrochloride (70 mg) was dissolved in methanol (1.4 ml), added with 10% palladium/carbon (35 mg) and stirred at 45 C. for 5 hours under hydrogen gas atmosphere. After insoluble matters were removed by filtration, the solvent was evaporated under reduced pressure to obtain 70.0 mg of the title compound. Yield: 99%. 1H-NMR(CD3OD) delta (ppm); 1.93 (2H, m), 2.06 (2H, m), 2.89 (1H, m), 3.13 (2H, m), 3.49 (2H, m), 7.20-7.34 (5H, m) MS (EI); m/z 161 (M+)
99% With palladium 10% on activated carbon; hydrogen; In methanol; at 20℃; for 4h;Inert atmosphere; To a stirred solution of 4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (300 mg, 1.53mmol) in MeOH (10 mL), 10% Pd-C (100 mg) was added at RT under argon atmosphere.The reaction mixture was flushed with H2 (3 times) and stirred under H2 atmosphere (balloon)for 4 h. After completion of the reaction (monitored by LCMS), the reaction mixture wasfiltered through a short pad of Celite and washed with MeOH (5 mL). The filtrate wasconcentrated under reduced pressure and the residue was washed with dry ether (2 x 5 mL) togive 4-phenylpiperidine hydrochloride (300 mg, 99%) as an off-white solid (hygroscopic).LCMS: m/z: 162.3 [M+Ht.
97% With hydrogen;5%-palladium/activated carbon; In methanol; under 1551.49 Torr; for 1h; 4-(4-Nitrophenyl)piperidine 4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride (10.38 g; 53.0 mmol) dissolved in methanol (160 ml) in the presence of palladium-on-charcoal (5%) (1.04 g) is hydrogenated under 30 psi of hydrogen for 1 hour.The medium is filtered through Celite and the filtrate is evaporated to dryness to give 4-phenylpiperidine hydrochloride (10.17 g; 97%).This intermediate (13 g; 65.7 mmol) is taken up in chloroform (430 ml), cooled to 0 C. and then treated with copper nitrate 2.5-hydrate (15.3 g; 65.7 mmol) for 15 minutes.The mixture is then added dropwise over 45 minutes to a solution of trifluoroacetic anhydride (65 ml; 460 mmol) in chloroform (70 ml).After stirring at 0 C. for 48 hours, the medium is poured onto ice, diluted with dichloromethane and neutralized by addition of concentrated sodium hydroxide (85 ml).The medium is extracted several times with dichloromethane and the organic phases are then combined, dried over magnesium sulfate, filtered and evaporated to dryness.The syrup obtained is purified by chromatography on a column of silica eluted with a 96.5/3/0.5 CH2Cl2/MeOH/NH4OH mixture to give pure compound 141A (8.35 g; 68%).
93% With hydrogen;10% palladium on activated carbon; In methanol; for 19h; 1,2,3,6-Tetrahydro-4-phenylpyridine hydrochloride (200 mg, 1.0 mmol) and 10% palladium-carbon (30 mg) were stirred in methanol (2 ml) for 19 hours in an atmosphere of hydrogen. The reaction solution was filtered and the resulting residue was thoroughly washed with methanol. Then the filtrate and washed solution were combined and evaporated under a reduced pressure to obtain 190 mg of the title compound (0.95 mmol, 93% in yield). 1H-NMR (CDCl3) delta 2.01-2.10 (2 H, m), 2.17-2.30 (2 H, m), 2.72-2.82 (1 H, m), 2.98-3.07 (2 H, m), 3.60-3.68 (2 H, m), 7.22-7.29 (3H, m), 7.31-7.37 (2 H, m); MW 197.71 (C11H16ClN); Mass spectrum EIMS m/z 161 (M)+
palladium; In methanol; ethyl acetate; Reference Example 4 4-Phenylpiperidine hydrochloride 1,2,5,6-Tetrahydro-4-phenylpyridine hydrochloride (125 g) and 12.0 g of 10 % palladium on carbon were suspended in 1 L of methanol, and the suspension was stirred at atmospheric pressure under a hydrogen atmosphere at room temperature for 5 hours. The insoluble material was removed through Celite, and the filtrate was concentrated under reduced pressure. The resulting residue was suspended in ethyl acetate and a small amount of ethanol, and the insoluble material was collected by filtration to give 60.3 g of 4-phenylpiperidine hydrochloride. 1H-NMR(DMSO-d6) delta ppm: 1.79-2.01 (4H, m), 2.73-3.08 (3H, m), 3.20-3.45 (2H, m), 7.10-7.40 (5H, m), 9.18 (2H, br-s)

 

Historical Records

Technical Information

Categories

Related Functional Groups of
[ 43064-12-6 ]

Aryls

Chemical Structure| 10338-69-9

A801760 [10338-69-9]

4-Phenyl-1,2,3,6-tetrahydropyridine

Similarity: 0.98

Chemical Structure| 28289-54-5

A749176 [28289-54-5]

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Similarity: 0.95

Chemical Structure| 13314-67-5

A335858 [13314-67-5]

1,2,3,6-Tetrahydro-4-(4-methylphenyl)-1-(phenylmethyl)pyridine

Similarity: 0.91

Chemical Structure| 38025-45-5

A821285 [38025-45-5]

1-Benzyl-4-phenyl-1,2,3,6-tetrahydropyridine

Similarity: 0.91

Chemical Structure| 103855-00-1

A410130 [103855-00-1]

4-(4-Bromophenyl)-1,2,3,6-tetrahydropyridine hydrochloride

Similarity: 0.89

Related Parent Nucleus of
[ 43064-12-6 ]

Pyridines

Chemical Structure| 23007-85-4

A211071 [23007-85-4]

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

Similarity: 0.98

Chemical Structure| 10338-69-9

A801760 [10338-69-9]

4-Phenyl-1,2,3,6-tetrahydropyridine

Similarity: 0.98

Chemical Structure| 28289-54-5

A749176 [28289-54-5]

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Similarity: 0.95

Chemical Structure| 13314-67-5

A335858 [13314-67-5]

1,2,3,6-Tetrahydro-4-(4-methylphenyl)-1-(phenylmethyl)pyridine

Similarity: 0.91

Chemical Structure| 38025-45-5

A821285 [38025-45-5]

1-Benzyl-4-phenyl-1,2,3,6-tetrahydropyridine

Similarity: 0.91