426463-05-0|2-Chloro-5-iodo-3-nitropyridine| Ambeed

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Quality Control of [ 426463-05-0 ] Purity: 97% SDS Specification

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Product Details of [ 426463-05-0 ]

CAS No. :	426463-05-0
Formula :	C₅H₂ClIN₂O₂
M.W :	284.44
SMILES Code :	[O-][N+](=O)C1=CC(I)=CN=C1Cl
MDL No. :	MFCD04038568
InChI Key :	PIJMRJPJERUFNI-UHFFFAOYSA-N
Pubchem ID :	1514294

Safety of [ 426463-05-0 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Computational Chemistry of [ 426463-05-0 ] Show Less

Physicochemical Properties

Num. heavy atoms	11
Num. arom. heavy atoms	6
Fraction Csp3	0.0
Num. rotatable bonds	1
Num. H-bond acceptors	3.0
Num. H-bond donors	0.0
Molar Refractivity	50.79
TPSA ? Topological Polar Surface Area: Calculated from Ertl P. et al. 2000 J. Med. Chem.	58.71 Å²

Lipophilicity

Log P_o/w (iLOGP)? iLOGP: in-house physics-based method implemented from Daina A et al. 2014 J. Chem. Inf. Model.	1.32
Log P_o/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry	2.29
Log P_o/w (WLOGP)? WLOGP: Atomistic method implemented from Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.	2.25
Log P_o/w (MLOGP)? MLOGP: Topological method implemented from Moriguchi I. et al. 1992 Chem. Pharm. Bull. Moriguchi I. et al. 1994 Chem. Pharm. Bull. Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.	1.63
Log P_o/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	0.91
Consensus Log P_o/w? Consensus Log P_o/w: Average of all five predictions	1.68

Water Solubility

Log S (ESOL):? ESOL: Topological method implemented from Delaney JS. 2004 J. Chem. Inf. Model.	-3.38
Solubility	0.118 mg/ml ; 0.000413 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble
Log S (Ali)? Ali: Topological method implemented from Ali J. et al. 2012 J. Chem. Inf. Model.	-3.16
Solubility	0.197 mg/ml ; 0.000691 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	-2.97
Solubility	0.307 mg/ml ; 0.00108 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble

Pharmacokinetics

GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg	High
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg	Yes
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) and tested on 415 molecules (test set) 10-fold CV: ACC=0.72 / AUC=0.77 External: ACC=0.88 / AUC=0.94	No
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.83 / AUC=0.90 External: ACC=0.84 / AUC=0.91	Yes
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.80 / AUC=0.86 External: ACC=0.80 / AUC=0.87	No
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) and tested on 2075 molecules (test set) 10-fold CV: ACC=0.78 / AUC=0.85 External: ACC=0.71 / AUC=0.81	No
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) and tested on 1068 molecules (test set) 10-fold CV: ACC=0.79 / AUC=0.85 External: ACC=0.81 / AUC=0.87	No
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) and tested on 2579 molecules (test set) 10-fold CV: ACC=0.77 / AUC=0.85 External: ACC=0.78 / AUC=0.86	No
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from Potts RO and Guy RH. 1992 Pharm. Res.	-6.41 cm/s

Druglikeness

Lipinski? Lipinski (Pfizer) filter: implemented from Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev. MW ≤ 500 MLOGP ≤ 4.15 N or O ≤ 10 NH or OH ≤ 5	0.0
Ghose? Ghose filter: implemented from Ghose AK. et al. 1999 J. Comb. Chem. 160 ≤ MW ≤ 480 -0.4 ≤ WLOGP ≤ 5.6 40 ≤ MR ≤ 130 20 ≤ atoms ≤ 70	None
Veber? Veber (GSK) filter: implemented from Veber DF. et al. 2002 J. Med. Chem. Rotatable bonds ≤ 10 TPSA ≤ 140	0.0
Egan? Egan (Pharmacia) filter: implemented from Egan WJ. et al. 2000 J. Med. Chem. WLOGP ≤ 5.88 TPSA ≤ 131.6	0.0
Muegge? Muegge (Bayer) filter: implemented from Muegge I. et al. 2001 J. Med. Chem. 200 ≤ MW ≤ 600 -2 ≤ XLOGP ≤ 5 TPSA ≤ 150 Num. rings ≤ 7 Num. carbon > 4 Num. heteroatoms > 1 Num. rotatable bonds ≤ 15 H-bond acc. ≤ 10 H-bond don. ≤ 5	0.0
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat implemented from Martin YC. 2005 J. Med. Chem.	0.55

Medicinal Chemistry

PAINS? Pan Assay Interference Structures: implemented from Baell JB. & Holloway GA. 2010 J. Med. Chem.	0.0 alert
Brenk? Structural Alert: implemented from Brenk R. et al. 2008 ChemMedChem	4.0 alert: heavy_metal
Leadlikeness? Leadlikeness: implemented from Teague SJ. 1999 Angew. Chem. Int. Ed. 250 ≤ MW ≤ 350 XLOGP ≤ 3.5 Num. rotatable bonds ≤ 7	No; 1 violation:MW<0.0
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties, trained on 12'782'590 molecules and tested on 40 external molecules (r² = 0.94)	2.43

Application In Synthesis of [ 426463-05-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 426463-05-0 ]
Downstream synthetic route of [ 426463-05-0 ]

[ 426463-05-0 ] Synthesis Path-Upstream 1~1

1
[ 426463-05-0 ]
[ 426463-09-4 ]

Yield	Reaction Conditions	Operation in experiment
92%	With hydrogenchloride; iron In ethanol; hexane; water; ethyl acetate	5-Iodo-3-amino-2-chloropyridine 5-iodo-3-nitro-2-chloropyridine (230 mg, 0.809 mmol), ethanol (1 mL), water (6 drops), and concentrated HCl (0.020 mL) were stirred at room temperature for 10 min. Iron (500 mg, 8.95 mmol) was then added in small portions and the reaction round bottom flask was placed into a 100° C. oil bath for 20 min. The iron was removed by filtration, washed with ethanol, then the combined ethanol layers were concentrated under reduced pressure. The crude residue was purified by flash chromatography using 9:1 hexane: ethyl acetate to give 5-iodo-3-amino-2-chloropyridine (190 mg, 92percent) as a colorless solid. mp 129° C.; ¹H NMR (CDCl₃) δ (ppm) 4.15 (br s, 2H), 7.34 (d, J=2.0 Hz, 1H), 7.96 (d, J=2.0 Hz, 1H); ¹³C NMR (CDCl₃) δ (ppm) 91.41, 129.67, 136.31, 140.77, 143.90. Analytical Calculated for C₅H₄N₂lCl: C, 23.60; H, 1.58; N, 11.01; Found: C, 23-66; H, 1.52; N, 10.98.

References: [1] Journal of Organic Chemistry, 2011, vol. 76, # 23, p. 9841 - 9844.
[2] Journal of Medicinal Chemistry, 2002, vol. 45, # 21, p. 4755 - 4761.
[3] Patent: US6538010, 2003, B1, .
[4] Bioorganic & Medicinal Chemistry Letters, 2003, vol. 13, # 3, p. 525 - 528.

[ 426463-05-0 ] Synthesis Path-Downstream 1~35

1
[ 623-33-6 ]
[ 426463-05-0 ]
[ 957193-63-4 ]

Yield	Reaction Conditions	Operation in experiment
82 - 94%	With triethylamine; In ethanol; at 80℃; for 4.0h;	Example 1. (5-Iodo-3-nitro-pyridin-2-ylamino)-acetic acid ethyl ester2-Chloro-5-iodo-3-m'tro-pyridine (13 g) was dissolved in ethanol. Glycine ethyl ester HCl was added (5.0 eq) followed by triethylamine (5.0 eq). The reaction mixture was heated to 8O0C for four (4) hours. The reaction mixture was concentrated to dryness and triturated with H2O to give the title compound as a white solid (82-94% yield). M.p. 2000C (dec), LCMS: m/z = 352.08 (M+H+), 1H-NMR (CDCl3, 400 MHz) delta 1.30 (t, J= 7.1 Hz, 3H), 4.25 (q, J= 7.1 Hz, 2H), 4.33 (d, J= 5.6 Hz, 2 H), 8.44 (bs, IH), 8.52 ( d, J= 2.0 Hz, IH), 8.69 ( d, J= 2.0 Hz, IH).

References: [1]Bioorganic and Medicinal Chemistry,2010,vol. 18,p. 4351 - 4362.
[2]Patent: WO2007/130468,2007,A2 .Location in patent: Page/Page column 84.

2
[ 15028-41-8 ]
[ 426463-05-0 ]
[ 957194-63-7 ]

Yield	Reaction Conditions	Operation in experiment
78%	With triethylamine; In ethanol; at 150℃; for 0.5h;Microwave irradiation;	2-(5-Iodo-3-nitro-pyridin-2-ylamino)-2-methyl-propionic acid methyl ester2-Chloro-5-iodo-3-nitro-pyridine (1.61 g) was dissolved in ethanol. Methyl a- aminoisobutyrate HCl was added (2.4 eq) followed by triethylamine (2.4 eq). The reaction mixture was heated to 1500C in a microwave oven for 30 minutes. The reaction mixture was concentrated to dryness and triturated with H2O. Silica gel chromatography of the resulting brown solid afforded the title compound as a bright yellow crystalline solid (78 % yield based on recovered starting material). M.p. 121-122 0C, 1H-NMR (CDCl3, 400 MHz) delta 1.56 (s, 3H), 1.66 (s, 3H), 3.67 (s, 3H), 8.53 (s, IH), 8.47 (d, J= 2.0 Hz, IH), 8.68 (d, J= 2.3 Hz, IH).

References: [1]Patent: WO2007/130468,2007,A2 .Location in patent: Page/Page column 120.

3
[ 6332-56-5 ]
[ 426463-05-0 ]

References: [1]Bioorganic and medicinal chemistry letters,2003,vol. 13,p. 525 - 528.
[2]Patent: US2014/94456,2014,A1 .
[3]Patent: WO2015/153683,2015,A1 .
[4]Patent: WO2005/121140,2005,A1 .

4
[ 426463-05-0 ]
7-tert-butoxycarbonyl-2-exo-(3'-amino-2'-chloro-5'-pyridinyl)-7-azabicyclo[2.2.1]heptane [ No CAS ]

References: [1]Bioorganic and medicinal chemistry letters,2003,vol. 13,p. 525 - 528.
[2]Journal of Medicinal Chemistry,2002,vol. 45,p. 4755 - 4761.

5
[ 426463-05-0 ]
[ 524070-13-1 ]

References: [1]Bioorganic and medicinal chemistry letters,2003,vol. 13,p. 525 - 528.

6
[ 426463-05-0 ]
(+/-)-5-azidoepibatidine [ No CAS ]

References: [1]Bioorganic and medicinal chemistry letters,2003,vol. 13,p. 525 - 528.
[2]Bioorganic and medicinal chemistry letters,2003,vol. 13,p. 525 - 528.

7
[ 426463-05-0 ]
2-(5-<i>tert</i>-butoxycarbonylamino-6-chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]heptane-7-carboxylic acid <i>tert</i>-butyl ester [ No CAS ]

References: [1]Bioorganic and medicinal chemistry letters,2003,vol. 13,p. 525 - 528.

8
[ 4214-75-9 ]
[ 426463-05-0 ]

References: [1]Journal of Medicinal Chemistry,2002,vol. 45,p. 4755 - 4761.
[2]Patent: US2015/11548,2015,A1 .
[3]Patent: WO2013/53983,2013,A1 .

9
[ 426463-05-0 ]
[ 426463-39-0 ]