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Structure of 42498-38-4

Chemical Structure| 42498-38-4

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Product Details of [ 42498-38-4 ]

CAS No. :42498-38-4
Formula : C11H14BrNO
M.W : 256.14
SMILES Code : O=C(NC(C)(C)C)C1=CC=C(Br)C=C1
MDL No. :MFCD00462539
InChI Key :FZMGMDLGMVXWCF-UHFFFAOYSA-N
Pubchem ID :603258

Safety of [ 42498-38-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 42498-38-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 42498-38-4 ]

[ 42498-38-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 51907-18-7 ]
  • [ 42498-38-4 ]
  • N-tert-butyl-4-(7-hydroxy-6,7-dihydro-5H-[2]pyrindin-7-yl)benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
c) N-tert-Butyl-4-(7-hvdroxv.6,7-dihydro-5H-[21vyridin-7-yl)benzamide; 5.3 ml of n-butyllithium (1.6M in hexane) are added dropwise to a solution of 4.250 mmol of 4-bromo-N-tert-butylbenzamide in 70 ml of tetrahydrofuran at -78°C. After 30 minutes, a solution of 3.270 mmol of 5,6-dihydro-[2]pyridin-7-one [51907-18-7] in 10 ml of tetrahydrofuran is added dropwise. The reaction mixture is stirred at-78°C for 1 hour and at room temperature for 2 hours and then quenched with saturated aqueous ammonium chloride solution. The organic phase is separated off and the aqueous phase is extracted with ethyl acetate (2x). The combined organic phases are dried with sodium sulphate and evaporated. The title compound is obtained as a white foam from the residue by flash chromatography (Si02 60F). Rf = 0.29 (toluene: methanol = 85: 15), Rt = 5.00.
 

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