[ CAS No. 41492-05-1 ] {[proInfo.proName]}

Name: 41492-05-1|1-Bromo-4-butylbenzene|98%
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Quality Control of [ 41492-05-1 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 41492-05-1 ]

Product Details of [ 41492-05-1 ]

CAS No. :	41492-05-1	MDL No. :	MFCD00040934
Formula :	C₁₀H₁₃Br	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	BRGVKVZXDWGJBX-UHFFFAOYSA-N
M.W :	213.11	Pubchem ID :	521059
Synonyms :

Calculated chemistry of [ 41492-05-1 ]

Physicochemical Properties

Num. heavy atoms :	11
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.4
Num. rotatable bonds :	3
Num. H-bond acceptors :	0.0
Num. H-bond donors :	0.0
Molar Refractivity :	53.53
TPSA :	0.0 Å²

Pharmacokinetics

GI absorption :	Low
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	Yes
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-4.46 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.9
Log Po/w (XLOGP3) :	4.42
Log Po/w (WLOGP) :	3.79
Log Po/w (MLOGP) :	4.26
Log Po/w (SILICOS-IT) :	3.98
Consensus Log Po/w :	3.87

Druglikeness

Lipinski :	1.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-4.15
Solubility :	0.015 mg/ml ; 0.0000705 mol/l
Class :	Moderately soluble
Log S (Ali) :	-4.14
Solubility :	0.0155 mg/ml ; 0.0000728 mol/l
Class :	Moderately soluble
Log S (SILICOS-IT) :	-4.86
Solubility :	0.00296 mg/ml ; 0.0000139 mol/l
Class :	Moderately soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	2.0
Synthetic accessibility :	1.29

Safety of [ 41492-05-1 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 41492-05-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 41492-05-1 ]
Downstream synthetic route of [ 41492-05-1 ]

[ 41492-05-1 ] Synthesis Path-Upstream 1~5

1
[ 41492-05-1 ]
[ 59662-46-3 ]

Reference： [1] Journal of Organometallic Chemistry, 2001, vol. 624, # 1-2, p. 208 - 216
[2] Journal of Organometallic Chemistry, 2001, vol. 624, # 1-2, p. 208 - 216
[3] Patent: WO2013/123456, 2013, A1,
[4] Patent: WO2017/84629, 2017, A1,
[5] Patent: WO2017/84630, 2017, A1,

2
[ 41492-05-1 ]
[ 79887-09-5 ]

Reference： [1] Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 2001, vol. 364, p. 711 - 718
[2] Bulletin of the Chemical Society of Japan, 2018, vol. 91, # 7, p. 1069 - 1074

3
[ 41492-05-1 ]
[ 1066-54-2 ]
[ 79887-09-5 ]

Reference： [1] Chemistry - A European Journal, 2018, vol. 24, # 57, p. 15303 - 15308

4
[ 121-43-7 ]
[ 41492-05-1 ]
[ 145240-28-4 ]

Yield	Reaction Conditions	Operation in experiment
38%	With hydrogenchloride; n-butyllithium In tetrahydrofuran; hexane	A. 4-Butyl-phenylboronic acid To a solution of 1-bromo-4-butylbenzene (6.24 g, 29.3 mmol) in tetrahydrofuran (32 mL) and ether (96 mL) at -78° C., n-butyllithium (1.6M in hexane, 21.9 mL, 35.1 mmol) was added dropwise. The mixture was stirred at -78° C. for 30 minutes and was added over 20 minutes to a solution of trimethyl borate (6.1 g, 58.6 mmol) in ether (64 mL) at -78° C. The mixture was stirred at -78° C. for 30 minutes and at room temperature overnight. 10percent aqueous hydrochloric acid (150 mL) was added, the mixture was shaken for 10 minutes, the ether layer was separated and the aqueous layer was extracted with ether (100 mL). The combined organic phases were extracted with 1N sodium hydroxide (3100 mL) and the combined aqueous extracts were washed once with ether, acidified to pH 1 with 6N hydrochloric acid and extracted with ether (3100 mL). The combined organic phases were washed with water, dried (magnesium sulfate) and concentrated to give compound A (2.0 g, 38percent).

Reference： [1] Patent: US5514696, 1996, A,
[2] Advanced Functional Materials, 2017, vol. 27, # 45,

5
[ 41492-05-1 ]
[ 145240-28-4 ]

Reference： [1] Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2002, vol. 515, # 1-2, p. 15 - 38
[2] Journal of Organic Chemistry, 2012, vol. 77, # 14, p. 5857 - 5860

[ 41492-05-1 ] Synthesis Path-Downstream 1~79

1
[ 778-28-9 ]
[ 18620-02-5 ]
[ 41492-05-1 ]

Reference： [1]Journal of the American Chemical Society,1935,vol. 57,p. 1311,1313

2
[ 41492-05-1 ]
[ 20651-71-2 ]

Reference： [1]Journal of the American Chemical Society,1959,vol. 81,p. 2149

3
[ 124-38-9 ]
[ 41492-05-1 ]
[ 20651-71-2 ]

Yield	Reaction Conditions	Operation in experiment
82%	With diethylzinc;palladium diacetate; tert-butyl XPhos; In hexanes; ISOPROPYLAMIDE; at 40℃; under 7600.51 Torr;	Example 2. Palladium-catalyzed carboxylations of aryl bromides withCO2 Observation of reagent effect. With the preferred conditions selected from the experimentation as disclosed in Example 1, a wide range of substituted aryl bromides bearing both electron-donating and electron-withdrawing groups were tested. Table 2 shows the yields obtained by different reagents running the following reaction: [Show Image] Wherein R represents any of the substituents listed in the final products of Table 2.Conditions: CO2 pressure = 10 atmPd(OAc)2 molar percentage = 5 mol %Compound of formula (I) with R1 = tert-butyl; R2, R3 and R4 = isopropyl; andR5, R6, R7, and R8 = H; molar percentage of compound of formula (I) = 10 mol %Organozinc derivative = diethylzinc (1.0 mmol, 1 M in hexanes)Initial amount of aryl halide = 0.5 mmol or 1.5 mmolSolvent: DMA / Hexanes (2:1)Temperature = 40 C

Reference： [1]Journal of the American Chemical Society,2009,vol. 131,p. 15974 - 15975
[2]Patent: EP2311788,2011,A1 .Location in patent: Page/Page column 6-7
[3]Zeitschrift fur Naturforschung. Teil B: Chemie, Biochemie, Biophysik, Biologie,1972,vol. 27,p. 774 - 779

4
[ 41492-05-1 ]
[ 1066-54-2 ]
[ 202524-78-5 ]

Yield	Reaction Conditions	Operation in experiment
80%	With copper(l) iodide; palladium diacetate; triethylamine; triphenylphosphine; at 80℃; for 4h;	To a solution of Pd(OAc)2 (13.5 mg, 0.06mmol), PPh3 (31.5 mg, 0.12 mmol), CuI (5.7 mg, 0.03 mmol), and <strong>[41492-05-1]1-bromo-4-butylbenzene</strong> (639 mg,3.00 mmol) in triethylamine (1 mL) was added a solution of trimethylsilylacetylene (324 mg, 3.30mmol). After the mixture was stirred at 80 oC for 4 h, the reaction mixture was acidified with 1NHCl aq. Water and EtOAc were added, and then the organic layer was separated. The aqueous layerwas extracted with EtOAc. The combined organic layer was washed with brine, dried over MgSO4,filtered through a pad of Celite, and then evaporated under reduced pressure. The residual brown oilwas chromatographed on silica gel with hexane/EtOAc = 100/1 (Rf = 0.43) to give1-(4-butylphenyl)-2-trimethylsilylacetylene (S8) as pale-yellow oil (550 mg, 2.40 mmol, 80 %). Theanalytical data were identical to the literature.S15 A suspension of S8 (550 mg, 2.40 mmol) andK2CO3 (495 mg, 3.58 mmol) in MeOH (12 mL) was stirred at room temperature for 4 h. Thereaction mixture was filtered through Celite with EtOAc, and the solvent of the filtrate was removedunder reduced pressure. Water and EtOAc were added, and then the organic layer was separated. Theaqueous layer was extracted with EtOAc. The combined organic layer was washed with brine, driedover MgSO4, filtered through a pad of Celite, and then evaporated under reduced pressure. Theresidual yellow oil was chromatographed on silica gel with hexane/EtOAc = 50/1 (Rf = 0.50) to give1-butyl-4-ethynylbenzene (S9) as pale-yellow oil (340 mg, 2.15 mmol, 90%). The analytical datawere identical to the literature.S16 To a solution of Pd(OAc)2 (8.8 mg, 0.039 mmol), PPh3 (20.5 mg,0.078 mmol), CuI (3.7 mg, 0.020 mmol), and S9 (416 mg, 1.95 mmol) in triethylamine (1 mL) wasadded a solution of 1-butyl-4-ethynylbenzene (340 mg, 2.15 mmol). After the mixture was stirred at80 oC for 4 h, the reaction mixture was acidified with 1N HCl aq. After the same work-up performedin the synthesis of S8, the residue was chromatographed on silica gel with hexane/EtOAc = 50/1 (Rf= 0.30) to give 4c as yellow solid (340 mg, 1.17 mmol, 60 %). The analytical data were identical tothe literature.S17

Reference： [1]Bulletin of the Chemical Society of Japan,2018,vol. 91,p. 1069 - 1074
[2]Journal of the Chemical Society. Perkin transactions I,1998,p. 1607 - 1611

5
[ 41492-05-1 ]
[ 109-73-9 ]
N-butyl-N-(4-butylphenyl)-4-butylaniline [ No CAS ]

Reference： [1]Journal of the American Chemical Society,1998,vol. 120,p. 3694 - 3703

6
[ 88-69-7 ]
[ 41492-05-1 ]
4-n-butyl-2'-isopropyldiphenyl ether [ No CAS ]

Reference： [1]Journal of the American Chemical Society,1999,vol. 121,p. 4369 - 4378

7
[ 201230-82-2 ]
[ 41492-05-1 ]
[ 20651-71-2 ]

Reference： [1]Russian Journal of Applied Chemistry,2005,vol. 78,p. 1844 - 1848
[2]Russian Journal of Organic Chemistry,1999,vol. 35,p. 1636 - 1639
[3]Russian Journal of Organic Chemistry,1998,vol. 34,p. 1464 - 1470

8
[ 41492-05-1 ]
[ 20651-73-4 ]

Yield	Reaction Conditions	Operation in experiment
50%	at 200℃; for 15h;

Reference： [1]Oehme, G. [Journal fur praktische Chemie (Leipzig 1954), 1984, vol. 326, # 5, p. 779 - 790]

9
[ 41492-05-1 ]
2-(4-n-butylphenyl)-1,10-phenanthroline [ No CAS ]
[ 356528-22-8 ]

Reference： [1]Journal of the American Chemical Society,2001,vol. 123,p. 6291 - 6299

10
[ 41492-05-1 ]
[ 145240-28-4 ]

Reference： [1]Mutation Research - Genetic Toxicology and Environmental Mutagenesis,2002,vol. 515,p. 15 - 38
[2]Journal of Organic Chemistry,2012,vol. 77,p. 5857 - 5860

11
[ 41492-05-1 ]
[ 25015-63-8 ]
[ 625458-85-7 ]

Reference： [1]Journal of the American Chemical Society,2010,vol. 132,p. 11825 - 11827
[2]Journal of Organic Chemistry,2008,vol. 73,p. 5589 - 5591
[3]Advanced Synthesis and Catalysis,2003,vol. 345,p. 580 - 583

12
[ 41492-05-1 ]
[ 3958-47-2 ]
[ 37909-95-8 ]

Reference： [1]Synthesis,2005,p. 485 - 492

13
[ 4325-82-0 ]
[ 41492-05-1 ]
1-butyl-4-(1,3-dimethylbut-2-enyloxy)-benzene [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2005,vol. 127,p. 8146 - 8149

14
[ 4664-01-1 ]
[ 41492-05-1 ]
3-(4-butyl-phenyl)-3-hydroxy-2,3-dihydro-pyrrolo[3,4-c]pyridin-1-one [ No CAS ]
[ 872216-48-3 ]

Reference： [1]Journal of Organic Chemistry,2005,vol. 70,p. 10502 - 10510

15
[ 41492-05-1 ]
[ 115-19-5 ]
[ 155906-12-0 ]

Yield	Reaction Conditions	Operation in experiment
	With triphenylphosphine;bis(triphenylphosphine)palladium(II)-chloride; copper(I) iodide; In triethylamine;	Step 6: <strong>[41492-05-1]1-Bromo-4-butylbenzene</strong> (235 g), 3-methyl-1-butyne-3-ol (139 g), triphenylphosphine (4.8 g) and bis(triphenylphosphine)palladium(II) chloride (2.8 g) were dissolved in triethylamine (1,000 ml), and then copper(I) iodide (0.8 g) was added thereto. After stirring at room temperature for 1 hour, the reaction mixture was further stirred at 90 C. for 5 hours. The resulting precipitated crystals were filtered, and then triethylamine was distilled off therefrom, followed by extracting with chloroform. The resultant was washed with 10% hydrochloric acid twice, and further with water twice, and then chloroform was distilled off therefrom. The residue was purified using silica gel-chloroform column chromatography to give 3-methyl-1-(4'-butylphenyl)-1-butyne-3-ol (100 g).

Reference： [1]Journal of Materials Chemistry,2009,vol. 19,p. 7525 - 7531
[2]Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals,2001,vol. 364,p. 711 - 718
[3]Patent: US5356558,1994,A
[4]Organic and Biomolecular Chemistry,2015,vol. 13,p. 2432 - 2436
[5]European Journal of Organic Chemistry,2018,vol. 2018,p. 4479 - 4482

16
[ 41492-05-1 ]
[ 98-80-6 ]
[ 37909-95-8 ]

Yield	Reaction Conditions	Operation in experiment
93%	With C24H20Cl2NPPdS; potassium carbonate; palladium; In toluene; at 100℃; for 2h;	General procedure: A 100 ml round bottom flask was fitted with a reflux condenser and a magnetic stirrer bar. The flask was charged with toluene (15 ml) and the appropriate amount of catalyst reagents and the internal standard (n-Decane: 2.59 mmol). The contents were thoroughly mixed and an initial sample (t0) was then taken. The reaction flask was placed in an oil bath at the desired temperature and the reaction mixture allowed to heat/reflux with stirring. A sample was taken and analyzed every 10 min for the first hour and every 30 min thereafter until t3h. In cases where conversionwas not complete after 3 h, the reaction mixturewas then allowed to stir for a total of 24 h. The reaction at 140 C was performed in a sealed tube. All catalytic reactions were done under aerobic conditions. Percentage conversions were determined by GC with n-decane as the internal standard and the coupling products were characterized by mass spectrometry (Table 4) as well as 1H NMR spectroscopy (Entry 5, Table 4 only).

Reference： [1]Journal of the American Chemical Society,2012,vol. 134,p. 3190 - 3198
[2]Journal of Heterocyclic Chemistry,2018,vol. 55,p. 551 - 555
[3]Applied Organometallic Chemistry,2015,vol. 29,p. 87 - 89
[4]Journal of Organometallic Chemistry,2012,vol. 703,p. 34 - 42
[5]Angewandte Chemie - International Edition,2006,vol. 45,p. 2868 - 2871
[6]Chemistry - A European Journal,2010,vol. 16,p. 1812 - 1818
[7]Organometallics,2010,vol. 29,p. 1729 - 1739
[8]Applied Catalysis A: General,2011,vol. 393,p. 231 - 241
[9]Organometallics,2011,vol. 30,p. 6270 - 6282
[10]Journal of Organometallic Chemistry,2018,vol. 868,p. 76 - 85

17
potassium [2-(dimethylamino)ethoxy]methyl}trifluoroborate [ No CAS ]
[ 41492-05-1 ]
[ 910251-41-1 ]

Yield	Reaction Conditions	Operation in experiment
25%	With caesium carbonate;dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In 1,4-dioxane; water; at 100℃; for 10h;	To a mixture of 1-bromo-4-buthylbenzene (50 mg, 0.24 mmol) and 1,4-dioxane (1.5 ml) were added water (0.15 ml), cesium carbonate (0.23 g, 0.71 mmol), potassium [2-(dimethylamino)ethoxy]methoxy}trifluorobrate (108 mg, 0.47 mmol), palladium (II) acetate (5.3 mg, 0.024 mmol) and 2-dicyclohexylphosphino-2',6'-dimethoxybiphenyl (19 mg, 0.047 mmol). Then, the reactionmixture was stirred at 100C (external temperature) for 10 hours. After the reaction mixture was cooled at room temperature, ethyl acetate and water were added to the mixture. The separated organic layer was washed with an aqueous saturated sodium chloride solution, and the organic layer was separated. After the organic layer was dried over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure. The residue was purified with silica gel column chromatography (heptane:ethyl acetate=6:1, NH silica gel) to obtain the title compound (14 mg, 0.058 mmol, 25%). 1H-NMR Spectrum (CDCl3) delta (ppm): 0.92 (3H, t, J=7.2Hz), 1.30-1.39(2H, m), 1.55-1.62(2H, m), 2.27(6H, s), 2.53(2H, t, J=5.8Hz), 2.60(2H, t, J=7.8Hz), 3.54(2H, t, J=5.8Hz), 4.50(2H, s), 7.15(2H, d, J=8.0Hz), 7.25(2H, d, J=8.0Hz).

Reference： [1]Patent: EP1867650,2007,A1 .Location in patent: Page/Page column 37

18
[ 41492-05-1 ]
[ 59662-46-3 ]

Reference： [1]Journal of Organometallic Chemistry,2001,vol. 624,p. 208 - 216
[2]Journal of Organometallic Chemistry,2001,vol. 624,p. 208 - 216
[3]Patent: WO2013/123456,2013,A1
[4]Patent: WO2017/84629,2017,A1
[5]Patent: WO2017/84630,2017,A1

19
[ 763-32-6 ]
[ 41492-05-1 ]
C₁₅H₂₂O [ No CAS ]
C₁₅H₂₂O [ No CAS ]
C₁₅H₂₂O [ No CAS ]
C₁₅H₂₂O [ No CAS ]
[ 874116-58-2 ]

Yield	Reaction Conditions	Operation in experiment
38%	With triethylamine; tris-(o-tolyl)phosphine;palladium diacetate; In acetonitrile; at 80 - 81℃; under 760.051 Torr; for 24h;	EXAMPLE 1-3Preparation of alkylated product from the mixture of <strong>[41492-05-1]1-bromo-4-butylbenzene</strong> and 3-methyl-3-buten-1-olTo a solution of 1.46 mmol (311 mg) of 4-bromobutylbenzene in 12 mL of acetonitrile, was added 0.073 mmol (16.4 mg) of palladium diacetate, 0.146 mmol (44.5 mg) of tri-ortho-tolylphosphine, 4.38 mmol (0.61 mL) of triethylamine and 1.46 mmol (0.147 mL) of 3-methyl-3-buten-1-ol. The mixture was refluxed at 80~81 DEG C. under ambient pressure for 24 hours. As illustrated in reaction formula II, the products were separated to the aldehyde and the mixture of the alkenes with column chromatography eluted with hexane and ethyl acetate (hexane:ethyl acetate=4:1). The yield is demonstrated in Table 1.

Reference： [1]Patent: US2006/20153,2006,A1 .Location in patent: Page/Page column 5; 6

20
[ 121-43-7 ]
[ 41492-05-1 ]
[ 145240-28-4 ]

Yield	Reaction Conditions	Operation in experiment
38%	With hydrogenchloride; n-butyllithium; In tetrahydrofuran; hexane;	A. 4-Butyl-phenylboronic acid To a solution of 1-bromo-4-butylbenzene (6.24 g, 29.3 mmol) in tetrahydrofuran (32 mL) and ether (96 mL) at -78 C., n-butyllithium (1.6M in hexane, 21.9 mL, 35.1 mmol) was added dropwise. The mixture was stirred at -78 C. for 30 minutes and was added over 20 minutes to a solution of trimethyl borate (6.1 g, 58.6 mmol) in ether (64 mL) at -78 C. The mixture was stirred at -78 C. for 30 minutes and at room temperature overnight. 10% aqueous hydrochloric acid (150 mL) was added, the mixture was shaken for 10 minutes, the ether layer was separated and the aqueous layer was extracted with ether (100 mL). The combined organic phases were extracted with 1N sodium hydroxide (3100 mL) and the combined aqueous extracts were washed once with ether, acidified to pH 1 with 6N hydrochloric acid and extracted with ether (3100 mL). The combined organic phases were washed with water, dried (magnesium sulfate) and concentrated to give compound A (2.0 g, 38%).

Reference： [1]Patent: US5514696,1996,A
[2]Advanced Functional Materials,2017,vol. 27

21
thrice-fused zinc chloride [ No CAS ]
[ 41492-05-1 ]
[ 157126-75-5 ]
4'-Butyl[1,1'-biphenyl]-4-propanoic acid, ethyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91%	With tert.-butyl lithium;tetrakis(triphenylphosphine)palladium (0); In tetrahydrofuran; pentane;	A. 4'-Butyl[1,1'-biphenyl]-4-propanoic acid, ethyl ester To a stirred solution of 3.20 g (15.0 mmol) of <strong>[41492-05-1]1-bromo-4-butylbenzene</strong> (Aldrich Chemical Company #33,576-2) at -78 C. under argon was added, dropwise over 30 min, 18.0 mL (30.6 mmol, 1.7M in pentane) of t-butyllithium solution. The resulting light yellow solution was warmed to 0 C. and stirred for 1 h. To this solution was added 3.4 g (25 mmol) of thrice-fused zinc chloride in 20 mL of THF. The resulting slurry was stirred for 30 min and then a solution of 2.0 g (6.5 mmol) of 4-iodobenzenepropanoic acid, ethyl ester (Example 43, Part B) and 0.4 g (0.35 mmol) of tetrakis(triphenylphosphine)palladium (0) in 5 mL of THF was added. The reaction was stirred for 16 h, diluted with ether and washed once with 10% citric acid. The organic phase was dried (MgSO4) and evaporated. Purification by flash chromatography on silica gel (5*20 cm column) eluted with 1:1 hexanes/dichloromethane gave title compound as a colorless oil, 1.79 g, 91% yield.

Reference： [1]Patent: US5470845,1995,A

22
[ 1198-30-7 ]
[ 41492-05-1 ]
[ 561290-54-8 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; magnesium;ethylene dibromide; In tetrahydrofuran; methanol; sodium hydroxide;	Example A13 Synthesis of (4-butylphenyl)(1-isoquinolyl)ketone Under a nitrogen atmosphere, 1-bromo-4-butylbenzene (2.29 ml, 13.0 mmol) was added to a mixed solution of magnesium (338 mg, 13.9 mmol) and tetrahydrofuran (6.5 ml), and as an initiator, catalytic amount of 1,2-dibromoethane was added, and this was stirred under reflux for 10 minutes. The solution was cooled to 0C, a tetrahydrofuran solution of <strong>[1198-30-7]1-isoquinolinecarbonitrile</strong> (1.0g, 6.49 mmol) was added, and was stirred for another 1 hour at room temperature, and at 70C for 3 hours. Subsequently, the solution was cooled again to 0C, concentrated hydrochloric acid (2.56 ml) and methanol (11 ml) were added, and then refluxed for 2 hours. The concentrated residue was dissolved in 5 N sodium hydroxide and toluene, and was filtered through celite. The toluene layer of the filtrate was divided, washed with water, dried over magnesium sulfate, and concentrated. The residue was purified by silica gel column chromatography to give 1.72 g of the title compound. 1H-NMR(CDCl3) delta (ppm):0.93(3H, t), 1.32-1.43(2H, m), 1.58-1.66(2H, m), 2.68(2H, t), 7.28(2H, d), 7.61(1H, td), 7.74(1H, td), 7.80(1H, d), 7.87(2H, d), 7.92(1H, d), 8.20(1H, d), 8.60(1H, d)
	With hydrogenchloride; magnesium;ethylene dibromide; In tetrahydrofuran; methanol; sodium hydroxide;	Example B3 (4-Butylphenyl) (1-isoquinolyl)ketone 1-Bromo-4-butylbenzene (2.29 ml, 13 mmol) and a catalytic amount of 1,2-dibromoethane as an initiator were added to a mixedsolution of magnesium (338 mg, 14 mmol) and tetrahydrofuran (6.5 ml) under nitrogen atmosphere, and this mixture was stirred under reflux for 10 minutes. The mixture was cooled to 0C, a solution of <strong>[1198-30-7]1-isoquinolinecarbonitrile</strong> (1.0 g, 6.5 mmol) in tetrahydrofuran was added, and this mixture was stirred at room temperature for 1 hour, then at 70C for 3 hours. Thereafter, the mixture was cooled again to 0C, concentrated hydrochloric acid (2.6 ml) and methanol (11 ml) were added, and this mixture was heated under reflux for 2 hours. After the mixture was concentrated, the residue was dissolved in 5 N sodium hydroxide and toluene, and was filtered through celite. The toluene layer of the filtrate was separated, washed with water, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (1.7 g). 1H-NMR(CDCl3) delta (ppm):0.93(3H, t), 1.32-1.43(2H, m), 1.58-1.66(2H, m), 2.68(2H, t), 7.28(2H, d), 7.61(1H, td), 7.74(1H, td), 7.80(1H, d), 7.87(2H, d), 7.92(1H, d), 8.20(1H, d), 8.60(1H, d)

Reference： [1]Patent: EP1300464,2003,A1
[2]Patent: EP1300464,2003,A1

23
[ 69861-71-8 ]
[ 41492-05-1 ]
[ 157106-76-8 ]

Reference： [1]Journal of the American Chemical Society,1994,vol. 116,p. 5969 - 5970
[2]Organometallics,1995,vol. 14,p. 3030 - 3039

24
[ 61676-62-8 ]
[ 41492-05-1 ]
[ 625458-85-7 ]

Yield	Reaction Conditions	Operation in experiment
90%	With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20℃;Inert atmosphere;	General procedure: 1-Bromo-4-methylbenzene (1.0 g, 5.88 mmol) was dissolved in 30 mL anhydrous THF under argon. The solution was cooled to -78 C before solution of n-BuLi (2.4 M) in hexane (3.4 mL, 8.16 mmol) was added dropwise. The reaction mixture was stirred for 10 min at -78 C. 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1.9 g, 10.2 mmol) was added then. The reaction mixture was allowed to warm up to room temperature and stirred overnight before it was poured into ice water. The solution was extracted with 100 mL dichloromethane (CH2Cl2), the organic layer washed with 70 mL brine and dried with Na2SO4 before the solvent was removed. The crude product was purified by column chromatography on silica gel with petroleum ether/CH2Cl2 (10:1, v/v) as an eluent to give a white solid (1.1 g, 85% yield).

Reference： [1]Dyes and Pigments,2013,vol. 98,p. 17 - 24
[2]Chemical Communications,2008,p. 1548 - 1550
[3]Journal of Organic Chemistry,2008,vol. 73,p. 9207 - 9213

25
lithium (pyridine-2-yl)triisopropoxyborate [ No CAS ]
[ 41492-05-1 ]
2-(4-n-butylphenyl)pyridine [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2008,vol. 47,p. 4695 - 4698

26
lithium triisopropyl 2-(6-methoxypyridyl) borate [ No CAS ]
[ 41492-05-1 ]
[ 1046789-37-0 ]

Reference： [1]Angewandte Chemie - International Edition,2008,vol. 47,p. 4695 - 4698

27
[ 124-38-9 ]
[ 41492-05-1 ]
[ 104-51-8 ]
[ 20651-71-2 ]

Yield	Reaction Conditions	Operation in experiment
17%; 64%	With diethylzinc;palladium diacetate; tert-butyl XPhos; In ISOPROPYLAMIDE; under 7600.51 Torr;Product distribution / selectivity;	Example 1. Reaction and yields in different organic solvents. The present example discloses the conversion of a non-activated aryl bromide (1 a) (p-n-butyl-bromobenzene) with CO2 to obtain the corresponding benzoic acid (2a). In order to render the process catalytic, diethylzinc was used as the reducing agent. The employed catalyst system comprised the palladium diacetate (Pd(OAc)2) with a compound of formula (I) with R1 = tert-butyl; R2, R3 and R4 = isopropyl; and R5, R6, R7, and R8= H. In all the studied cases, significant amounts of dehalogenated and Negishi-type products, (3) and (4), respectively, were observed. The reaction is schematically illustrated below: [Show Image] wherein X is CO2H (product type 2a - corresponding benzoic acid), or H (product type 3), or ethyl (product type 4 Negishi-type products) To perform the reaction 0.5 mmol of (1 a) were employed, the molar percentage of Pd(OAc)2 was 5.0 mol %, the compound of formula (I) as above defined was used in a molar percentage of 10 mol %. The pressure of CO2 was of 1 atm or 10 atm. Following Table 1 lists different process conditions applied to the reaction illustrated above. The percentage by weight of the achieved products measured by gas chromatography using dodecane as internal standard, is shown: ; As can be deduced from Table 1, the nature of the organic solvent has a crucial impact on the reaction outcome. Thus, while dimethylacetamide (DMA) and dimethylformamide (DMF) clearly favored the carboxylation, N-methylpyrrolidone (NMP) or dimethylsulfoxide (DMSO) resulted in the exclusive formation of dehalogenated (3) and Negishi-type products (4). It is worth mentioning that the use of diethylacetamide (DEA), structurally related to DMA, led to the preferential formation of Negishi-type products (4), hence indicating the subtleties of this system (data not shown). Substitution of the organozinc by triethylaluminium or triethylsilane, among others, had also a deleterious effect, affording preferentially dehalogenated and Negishi-type products, (3) and (4) as final products (data not shown). Entry 5 shows the results using diisopropylzinc (2.0 equivalents) as organozinc compound. As can be seen, the yield of the corresponding carboxylic acid obtained is lower than the corresponding with the same solvent (DMA) but using diethylzinc (Entry 1 of table 1), thus being diethylzinc the preferred organozinc reagent. Nonetheless, the best results were finally obtained by operating at a higher CO2 pressure (10 atm), thus leading to formation of the benzoic acid (2a) in a 64 % isolated yield (entry 6 of table).

28
[ 124-38-9 ]
[ 41492-05-1 ]
[ 557-20-0 ]
[ 104-51-8 ]
[ 15181-08-5 ]
[ 20651-71-2 ]

Yield	Reaction Conditions	Operation in experiment
28%; 27%; 19%	palladium diacetate; tert-butyl XPhos; In N,N-dimethyl-formamide; under 760.051 Torr;	Example 1. Reaction and yields in different organic solvents. The present example discloses the conversion of a non-activated aryl bromide (1 a) (p-n-butyl-bromobenzene) with CO2 to obtain the corresponding benzoic acid (2a). In order to render the process catalytic, diethylzinc was used as the reducing agent. The employed catalyst system comprised the palladium diacetate (Pd(OAc)2) with a compound of formula (I) with R1 = tert-butyl; R2, R3 and R4 = isopropyl; and R5, R6, R7, and R8= H. In all the studied cases, significant amounts of dehalogenated and Negishi-type products, (3) and (4), respectively, were observed. The reaction is schematically illustrated below: [Show Image] wherein X is CO2H (product type 2a - corresponding benzoic acid), or H (product type 3), or ethyl (product type 4 Negishi-type products) To perform the reaction 0.5 mmol of (1 a) were employed, the molar percentage of Pd(OAc)2 was 5.0 mol %, the compound of formula (I) as above defined was used in a molar percentage of 10 mol %. The pressure of CO2 was of 1 atm or 10 atm. Following Table 1 lists different process conditions applied to the reaction illustrated above. The percentage by weight of the achieved products measured by gas chromatography using dodecane as internal standard, is shown: ; As can be deduced from Table 1, the nature of the organic solvent has a crucial impact on the reaction outcome. Thus, while dimethylacetamide (DMA) and dimethylformamide (DMF) clearly favored the carboxylation, N-methylpyrrolidone (NMP) or dimethylsulfoxide (DMSO) resulted in the exclusive formation of dehalogenated (3) and Negishi-type products (4). It is worth mentioning that the use of diethylacetamide (DEA), structurally related to DMA, led to the preferential formation of Negishi-type products (4), hence indicating the subtleties of this system (data not shown). Substitution of the organozinc by triethylaluminium or triethylsilane, among others, had also a deleterious effect, affording preferentially dehalogenated and Negishi-type products, (3) and (4) as final products (data not shown). Entry 5 shows the results using diisopropylzinc (2.0 equivalents) as organozinc compound. As can be seen, the yield of the corresponding carboxylic acid obtained is lower than the corresponding with the same solvent (DMA) but using diethylzinc (Entry 1 of table 1), thus being diethylzinc the preferred organozinc reagent. Nonetheless, the best results were finally obtained by operating at a higher CO2 pressure (10 atm), thus leading to formation of the benzoic acid (2a) in a 64 % isolated yield (entry 6 of table).

Reference： [1]Patent: EP2311788,2011,A1 .Location in patent: Page/Page column 5-6
[2]Journal of the American Chemical Society,2009,vol. 131,p. 15974 - 15975
[3]Journal of the American Chemical Society,2009,vol. 131,p. 15974 - 15975
[4]Journal of the American Chemical Society,2009,vol. 131,p. 15974 - 15975
[5]Journal of the American Chemical Society,2009,vol. 131,p. 15974 - 15975

29
[ 124-38-9 ]
[ 41492-05-1 ]
[ 557-20-0 ]
[ 15181-08-5 ]
[ 20651-71-2 ]

Reference： [1]Journal of the American Chemical Society,2009,vol. 131,p. 15974 - 15975

30
[ 41492-05-1 ]
[ 104-51-8 ]

Yield	Reaction Conditions	Operation in experiment
99%	With carbon dioxide; diethylzinc;palladium diacetate; tert-butyl XPhos; In 1-methyl-pyrrolidin-2-one; under 760.051 Torr;	Example 1. Reaction and yields in different organic solvents. The present example discloses the conversion of a non-activated aryl bromide (1 a) (p-n-butyl-bromobenzene) with CO2 to obtain the corresponding benzoic acid (2a). In order to render the process catalytic, diethylzinc was used as the reducing agent. The employed catalyst system comprised the palladium diacetate (Pd(OAc)2) with a compound of formula (I) with R1 = tert-butyl; R2, R3 and R4 = isopropyl; and R5, R6, R7, and R8= H. In all the studied cases, significant amounts of dehalogenated and Negishi-type products, (3) and (4), respectively, were observed. The reaction is schematically illustrated below: [Show Image] wherein X is CO2H (product type 2a - corresponding benzoic acid), or H (product type 3), or ethyl (product type 4 Negishi-type products) To perform the reaction 0.5 mmol of (1 a) were employed, the molar percentage of Pd(OAc)2 was 5.0 mol %, the compound of formula (I) as above defined was used in a molar percentage of 10 mol %. The pressure of CO2 was of 1 atm or 10 atm. Following Table 1 lists different process conditions applied to the reaction illustrated above. The percentage by weight of the achieved products measured by gas chromatography using dodecane as internal standard, is shown: ; As can be deduced from Table 1, the nature of the organic solvent has a crucial impact on the reaction outcome. Thus, while dimethylacetamide (DMA) and dimethylformamide (DMF) clearly favored the carboxylation, N-methylpyrrolidone (NMP) or dimethylsulfoxide (DMSO) resulted in the exclusive formation of dehalogenated (3) and Negishi-type products (4). It is worth mentioning that the use of diethylacetamide (DEA), structurally related to DMA, led to the preferential formation of Negishi-type products (4), hence indicating the subtleties of this system (data not shown). Substitution of the organozinc by triethylaluminium or triethylsilane, among others, had also a deleterious effect, affording preferentially dehalogenated and Negishi-type products, (3) and (4) as final products (data not shown). Entry 5 shows the results using diisopropylzinc (2.0 equivalents) as organozinc compound. As can be seen, the yield of the corresponding carboxylic acid obtained is lower than the corresponding with the same solvent (DMA) but using diethylzinc (Entry 1 of table 1), thus being diethylzinc the preferred organozinc reagent. Nonetheless, the best results were finally obtained by operating at a higher CO2 pressure (10 atm), thus leading to formation of the benzoic acid (2a) in a 64 % isolated yield (entry 6 of table).

31
[ 41492-05-1 ]
[ 557-20-0 ]
[ 104-51-8 ]
[ 15181-08-5 ]

Yield	Reaction Conditions	Operation in experiment
31%; 69%	With carbon dioxide;palladium diacetate; tert-butyl XPhos; In dimethyl sulfoxide; under 760.051 Torr;	Example 1. Reaction and yields in different organic solvents. The present example discloses the conversion of a non-activated aryl bromide (1 a) (p-n-butyl-bromobenzene) with CO2 to obtain the corresponding benzoic acid (2a). In order to render the process catalytic, diethylzinc was used as the reducing agent. The employed catalyst system comprised the palladium diacetate (Pd(OAc)2) with a compound of formula (I) with R1 = tert-butyl; R2, R3 and R4 = isopropyl; and R5, R6, R7, and R8= H. In all the studied cases, significant amounts of dehalogenated and Negishi-type products, (3) and (4), respectively, were observed. The reaction is schematically illustrated below: [Show Image] wherein X is CO2H (product type 2a - corresponding benzoic acid), or H (product type 3), or ethyl (product type 4 Negishi-type products) To perform the reaction 0.5 mmol of (1 a) were employed, the molar percentage of Pd(OAc)2 was 5.0 mol %, the compound of formula (I) as above defined was used in a molar percentage of 10 mol %. The pressure of CO2 was of 1 atm or 10 atm. Following Table 1 lists different process conditions applied to the reaction illustrated above. The percentage by weight of the achieved products measured by gas chromatography using dodecane as internal standard, is shown: ; As can be deduced from Table 1, the nature of the organic solvent has a crucial impact on the reaction outcome. Thus, while dimethylacetamide (DMA) and dimethylformamide (DMF) clearly favored the carboxylation, N-methylpyrrolidone (NMP) or dimethylsulfoxide (DMSO) resulted in the exclusive formation of dehalogenated (3) and Negishi-type products (4). It is worth mentioning that the use of diethylacetamide (DEA), structurally related to DMA, led to the preferential formation of Negishi-type products (4), hence indicating the subtleties of this system (data not shown). Substitution of the organozinc by triethylaluminium or triethylsilane, among others, had also a deleterious effect, affording preferentially dehalogenated and Negishi-type products, (3) and (4) as final products (data not shown). Entry 5 shows the results using diisopropylzinc (2.0 equivalents) as organozinc compound. As can be seen, the yield of the corresponding carboxylic acid obtained is lower than the corresponding with the same solvent (DMA) but using diethylzinc (Entry 1 of table 1), thus being diethylzinc the preferred organozinc reagent. Nonetheless, the best results were finally obtained by operating at a higher CO2 pressure (10 atm), thus leading to formation of the benzoic acid (2a) in a 64 % isolated yield (entry 6 of table).

32
[ 104-13-2 ]
[ 41492-05-1 ]
[ 227003-50-1 ]

Yield	Reaction Conditions	Operation in experiment
88%	With tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine; sodium t-butanolate; In toluene; for 24h;Reflux;	To the round bottom flask was added 4-butylbenzenamine(2.40 g, 11.25 mmol) <strong>[41492-05-1]1-bromo-4-butylbenzene</strong>(1.12 g, 7.5 mmol), sodium tert-butoxide (1.075 g, 11.25 mmol), Tris(dibenzylideneacetone)dipalladium(0) (0.14 g, 0.15 mmol) toluene (50 mL), tri-tert-butylphosphine (0.03 g, 0.15 mmol) was added, and the mixture was refluxed for 24 hours. After confirming with HPLC and LC-MASS, the reaction was terminated, After removal of solvent, extract with MC / H2O. Column (EA: HEX = 1: 4), reprecipitated in MC / hexane and vacuum dried, bis(4-butylphenyl)amine 1.85 g (Yield: 88%).
	With palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; for 15h;Reflux;	Three copies of 4-butylaniline, 4.7 copies of 4-bromo-butylbenzenes, 0.23 copy of palladium acetate (II), 1.9 copies of 2,2 -bis (diphenylphospino)-1,1'-binaphthyl and 2.9 copies of sodium tert-butoxide were added to 35 copies of toluene, and it was made to react under heating-at-reflux conditions for 15 hours. Chloroform water separated and refined the reaction mixture by column chromatography (ethyl acetate hexane) after condensing extraction and a chloroform phase, and it obtained 4.5 copies of compounds denoted by a following formula (300) as a yellow solid.
		0.1 mol of 4-n-butylaniline and 0.1 mol of potassium t-butoxide were placed under a nitrogen atmosphere.Add to a three-necked flask equipped with a thermometer, a dropping funnel and a condenser.Using acetonitrile as a solvent, the temperature was raised to 80 C, and stirred under reflux for 0.5 h.Slowly add 0.1 mol of <strong>[41492-05-1]1-bromo-4-n-butylbenzene</strong> to maintain a constant reaction temperature of 90 C.After 7 h of reaction, the reaction product was cooled to room temperature.A solid such as potassium t-butoxide is removed by filtration, and acetonitrile is removed by atmospheric distillation.A blue-brown 4,4'-dibutyldiphenylamine solution is obtained.

Reference： [1]Journal of Organic Chemistry,2010,vol. 75,p. 6771 - 6781
[2]Patent: KR2019/61746,2019,A .Location in patent: Paragraph 0168-0171
[3]Patent: JP2016/196423,2016,A .Location in patent: Paragraph 0088; 0089
[4]Patent: CN108794338,2018,A .Location in patent: Paragraph 0015; 0016

33
[ 41492-05-1 ]
[ 62-53-3 ]
N,N-bis(4-n-butylphenyl)aniline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91.4%		Compound 5 was prepared according to the literature [18]. A solution of <strong>[41492-05-1]1-bromo-4-butylbenzene</strong> (7.033 g, 33 mmol) was added to tris(dibenzylideneacetone) dipalladium (Pd2(dba)3) (0.302 g, 0.33 mmol) and bis(diphenylphosphino)ferrocene (DPPF) (0.274 g, 0.495 mmol) in toluene (70 mL) under nitrogen atmosphere at room temperature, and the resultant mixture was stirred at that temperature for 10 min. Afterwards, sodium tert-butoxide (3.618 g, 37.65 mmol) and aniline (1.397 g, 15 mmol) was added to the solution and stirred at 100 C for 24 h. Following the standard workup procedure, the reaction mixture was purified by flash column chromatography (silica gel, petroleum ether: dichloromethane, 10:1) to attain the product (4.885 g, 91.4% yield) as yellowish oil. 1H-NMR (CDCl3, 400 MHz) delta: 0.93 (t, J = 7.3 Hz, 6H), 1.32-1.41 (m, 4H), 1.55-1.62 (m, 4H), 2.55 (t, J = 7.8 Hz, 4H), 6.92 (t, J = 7.3 Hz, 1H), 6.98 (d, J = 8.5 Hz, 4H), 7.03-7.05 (m, 6H), 7.16-7.21 (m, 2H).

Reference： [1]Journal of Organic Chemistry,2010,vol. 75,p. 6771 - 6781
[2]Journal of Photochemistry and Photobiology A: Chemistry,2013,vol. 272,p. 58 - 64
[3]Journal of Polymer Science, Part A: Polymer Chemistry,2011,vol. 49,p. 1129 - 1137

34
[ 41492-05-1 ]
[ 994-71-8 ]
[ 80221-11-0 ]

Yield	Reaction Conditions	Operation in experiment
78%	With tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; at 100℃; for 2h;Inert atmosphere;	Tetrakis(triphenylphosphino) palladium(0) (64 mg, 1.7 mol%), triphenylphosphine (12 mg, 1.4 mol%), <strong>[41492-05-1]1-bromo-4-n-butylbenzene</strong> (1.20 mL, 6.80 mmol, 2.05 eq.), 1 (2.01 g, 3.32 mmol), and p-dioxane (20 mL) were combined in a Schlenk flask and heated to 100 C for 2 h. The volatiles were removed in vacuo and the brown oil was dissolved in Et2O (20 mL). This was washed with saturated KF(aq) (2 x 20 mL). The aqueous layer was washed with more Et2O (20 mL) and the combined organic layers were dried with MgSO4, filtered and the Et2O was allowed to evaporate. The resulting solid/oil mixture was taken up in hexanes and chromatographed through a short pad of silica gel (4 x 4 cm) with hexanes as the eluent (Rf = 0.75). The solvent was evaporated and the solid was recrystallized from hot methanol to give large colorless crystals of 5 (0.75 g, 78%). m. p.: 36-38 C. 1H NMR (CDCl3; 90 MHz): d 7.28 (dd, J = 27 Hz, 8.1 Hz, 8 H), 2.61 (t, J = 7.0 Hz, 4 H), 1.45 (m, 8 H), 0.92 (t, 6.3 Hz, 6 H). 13C NMR (CDCl3; 22.635 MHz): d 143.2, 131.5 (C-H), 128.4 (C-H), 120.7, 88.9 (acetylene), 35.6 (C-H), 33.4 (C-H), 22.3 (C-H), 13.9(C-H). UV/Vis (toluene): lmax 308 nm (e = 92,400). HR-MS (EI): for C22H26: calc?d: 290.2035; found: 290.2038.

Reference： [1]Tetrahedron Letters,2011,vol. 52,p. 1960 - 1963

35
[ 41492-05-1 ]
[ 531-91-9 ]
[ 79183-76-9 ]

Reference： [1]Journal of the American Chemical Society,2011,vol. 133,p. 1375 - 1382

36
[ 41492-05-1 ]
[ 1332887-35-0 ]

Yield	Reaction Conditions	Operation in experiment
79%	With N-hydroxyphthalimide; ammonium cerium (IV) nitrate; In acetonitrile; at 0 - 20℃;Inert atmosphere;	General procedure: To a solution of 4-phenylbutyl benzoate 1a (127 mg, 0.5 mmol) and N-hydroxyphthalimide (8.16 mg, 0.05 mmol) in CH3CN (1.7 mL) was added cerium(IV) ammonium nitrate (548 mg, 1.0 mmol) at 0 C. The reaction mixture was immediately warmed to room temperature and stirred for 2 h. The mixture was then filtered through a short column of alumina (hexane-EtOAc 1:1), and the filtrate was concentrated. The residue was purified with flash column chromatography (silica gel, hexane-EtOAc 70:1 to 50:1) to provide 4-benzoyloxy-1-phenylbutyl nitrate 2a in 81% yield (128 mg). 1.0 mmol) at 0 C. The reaction mixture was immediately warmed to room temperature and stirred for 2 h. The mixture was then filtered through a short column of alumina (hexane-EtOAc 1:1), and the filtrate was concentrated. The residue was purified with flash column chromatography (silica gel, hexane-EtOAc 70:1 to 50:1) to provide 4-benzoyloxy-1-phenylbutyl nitrate 2a in 81% yield (128 mg).

Reference： [1]Tetrahedron Letters,2011,vol. 52,p. 4654 - 4657

37
[ 41492-05-1 ]
[ 20651-66-5 ]
[ 20651-65-4 ]

Reference： [1]Organic Letters,2017,vol. 19,p. 2853 - 2856
[2]Journal of the American Chemical Society,2011,vol. 133,p. 18106 - 18109
[3]Journal of the American Chemical Society,2014,vol. 136,p. 3792 - 3795
[4]Organometallics,2015,vol. 34,p. 4775 - 4780
[5]Journal of the American Chemical Society,2015,vol. 137,p. 13433 - 13438

38
[ 225931-80-6 ]
[ 1160861-53-9 ]
[ 41492-05-1 ]
[ 1345093-37-9 ]

Reference： [1]Journal of the American Chemical Society,2011,vol. 133,p. 18106 - 18109

39
[ 225931-80-6 ]
[ 41492-05-1 ]
[ 1262046-34-3 ]
[ 1345093-35-7 ]

Reference： [1]Journal of the American Chemical Society,2011,vol. 133,p. 18106 - 18109

40
[ 41492-05-1 ]
[ 1262046-34-3 ]
[ 1345093-36-8 ]

Reference： [1]Journal of the American Chemical Society,2011,vol. 133,p. 18106 - 18109

41
[ 41492-05-1 ]
[ 95-92-1 ]
[ 80120-35-0 ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: p-bromobutylbenzene With iodine; magnesium In tetrahydrofuran Inert atmosphere; Stage #2: oxalic acid diethyl ester In tetrahydrofuran at -78 - 20℃; for 14h; Inert atmosphere;
	Stage #1: p-bromobutylbenzene With iodine; magnesium In tetrahydrofuran for 4h; Inert atmosphere; Reflux; Stage #2: oxalic acid diethyl ester In tetrahydrofuran at -78 - 20℃; for 14h; Inert atmosphere;

Reference： [1]Rana, Nirmal K.; Singh, Vinod K. [Organic Letters, 2011, vol. 13, # 24, p. 6520 - 6523]
[2]Ji, Xiaolei; Shen, Chaoren; Tian, Xinxin; Dong, Kaiwu [Organic Letters, 2021, vol. 23, # 21, p. 8645 - 8649]

42
[ 41492-05-1 ]
[ 73183-34-3 ]
[ 625458-85-7 ]

Yield	Reaction Conditions	Operation in experiment
90%	With potassium acetate;(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 110℃; for 12h;	[Experimental embodiment 4]: preparation of the compound in formula (I-3)Step 1: synthesize the compound in formula (3-A) (hereinafter ?compound (3-A)?).First, 3.2 grams (15 millimoles) of 4-bromo-1-butyl benzene in formula (3) and 4.2 grams (16.5 millimoles) of bis(pinacolate)diboron, and 4.4 grams (45 millimoles) of potassium acetate are dissolved in 30 mL of DMF. After the above mixture is stirred to a uniform state, 0.05 gram of 1,1'-bis((diphenylphosphino)ferrocene)dichloropalladium is added, and the resulting mixture is heated to 110 C. and stirred for 12 hours. After reacting, 50 mL of water is added to the mixture, and the mixture is extracted by ethyl acetate. An organic layer of the mixture solution is desiccated by waterless magnesium sulfate and is then filtered and concentrated. Afterwards, column chromatography (silicone, hexane) is performed to purify the product, thereby obtaining 3.5 grams of the compound (3-A). The yield is 90%.

Reference： [1]Patent: US2012/264984,2012,A1 .Location in patent: Page/Page column 6-7
[2]Israel Journal of Chemistry,2010,vol. 50,p. 691 - 695
[3]Chemistry - A European Journal,2017,vol. 23,p. 8921 - 8931
[4]Angewandte Chemie - International Edition,2012,vol. 51,p. 536 - 539
[5]Organic and Biomolecular Chemistry,2016,vol. 14,p. 10090 - 10094

43
[ 41492-05-1 ]
[ 68-12-2 ]
[ 1200-14-2 ]

Yield	Reaction Conditions	Operation in experiment
86.1%		To a solution of 4-bromo-4-butylbenzene 19 (4.0 g, 18.8 mmol) was added n-butyllithum (35 mL, 1.6 M in hexane, 56.3 mmol) over 30 min at -78 C. After stirring at -78 C for 2 h, dimethylformamide (3.7 mL, 56.3 mmol) in 10 mL dry tetrahydrofuran was added over 15 min. The mixture was warmed to room temperature gradually, poured into ice-water, and extracted by petroleum ether (100 mL × 4). The organic layers were combined, washed with 100 mL brine, dried over anhydrous sodium sulfate, and evaporated in vacuo. The residue was purified by column chromatography on silica gel using dichloromethane/petroleum ether (1/10, v/v) as eluent to give 20 (2.62 g, 86.1% yield) as a yellowish oil. 1H NMR (400 MHz, CDCl3): delta 9.97 (s, 1H), 7.79 (d, 2H, J = 7.6 Hz), 7.33 (d, 2H, J = 7.6 Hz), 2.69 (t, 2H, J = 7.6 Hz), 1.62 (m, 2H), 1.36 (m, 2H) and 0.93 (t, 3H, J = 7.2 Hz) ppm.

Reference： [1]Bioorganic and Medicinal Chemistry,2012,vol. 20,p. 1240 - 1250

44
[ 41492-05-1 ]
[ 633-70-5 ]
[ 1372406-26-2 ]

Reference： [1]Journal of Photochemistry and Photobiology A: Chemistry,2012,vol. 227,p. 59 - 64

45
[ 486-52-2 ]
[ 41492-05-1 ]
[ 1380543-30-5 ]

Reference： [1]Advanced Synthesis and Catalysis,2012,vol. 354,p. 1551 - 1558

46
[ 41492-05-1 ]
[ 59142-68-6 ]
[ 57297-29-7 ]
[ 1384863-24-4 ]

Reference： [1]Organic Letters,2012,vol. 14,p. 3800 - 3803

47
[ 41492-05-1 ]
[ 1313221-26-9 ]
[ 1313221-28-1 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium t-butanolate;tris-(dibenzylideneacetone)dipalladium(0); tri tert-butylphosphoniumtetrafluoroborate; In toluene; at 110℃; for 2h;Inert atmosphere;	Example 4: Synthesis of compound (IV); Gas in a 100 mL two-neck flack was replaced with nitrogen. Then 0.90 g of compound (III) synthesized above and 0.35 g of <strong>[41492-05-1]1-bromo-4-n-butylbenzene</strong> were placed in the flask and dissolved in 15 mL of toluene. The obtained solution was bubbled with argon for 30 minutes. Then 3.5 mg of tris(dibenzylideneacetone)bispalladium, 2.2 mg of tri(tert-butyl)phosphinetetrafluoroborate, and 0.15 g of sodium tert-butoxide were added, and the resultant mixture was stirred at 110C for 2 hours. After the mixture was allowed to cool, 10 mL of water was added, and the organic layer was separated from the aqueous layer. The aqueous layer was extracted a plurality of times with toluene, and a plurality of extracted organic layers were combined and washed with water and saturated brine. After the product was filtrated through a glass filter covered with 10 g of silica gel, the solvent was removed by evaporation to obtain 1.12 g of a crude product of compound (IV). 1H-NMR (CDCl3) delta (ppm) = 0.52 (4H, br), 0.83-0.98 (28H, m), 1.09-1.50 (48H, m), 1.56-1.72 (12H, m), 2.57 (8H, t), 2.70 (4H, t), 6.23 (2H, s), 6.39 (2H, d), 6.67 (2H, s), 6.83-6.91 (14H, m), 6.99 (12H, d), 7.27 (4H, d) LC-MS APCI, positive 1502 ([M+H]+, exact mass = 1501)

Reference： [1]Patent: EP2520576,2012,A1 .Location in patent: Page/Page column 75

48
[ 225931-80-6 ]
[ 1160861-53-9 ]
[ 41492-05-1 ]
C₄₁H₆₂BrO₂PPd [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2012,vol. 134,p. 19922 - 19934

49
[ 225931-80-6 ]
[ 41492-05-1 ]
[ 564483-19-8 ]
C₃₉H₅₈BrPPd [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2012,vol. 134,p. 19922 - 19934

50
[ 225931-80-6 ]
[ 41492-05-1 ]
[ 1160861-59-5 ]
C₅₃H₇₄BrO₂PPd [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
37%	In pentane at 20℃; for 12h; Inert atmosphere;

Reference： [1]Milner, Phillip J.; Maimone, Thomas J.; Su, Mingjuan; Chen, Jiahao; Müller, Peter; Buchwald, Stephen L. [Journal of the American Chemical Society, 2012, vol. 134, # 48, p. 19922 - 19934]

51
[ 225931-80-6 ]
[ 1070663-78-3 ]
[ 41492-05-1 ]
C₄₅H₆₆BrO₂PPd [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2012,vol. 134,p. 19922 - 19934

52
[ 41492-05-1 ]
[ 99768-12-4 ]
[ 1451206-56-6 ]

Yield	Reaction Conditions	Operation in experiment
86%	With sodium carbonate; In ethanol; toluene; for 5h;Inert atmosphere; Reflux;	[00269] General Method 13: The synthesis of a biaryl or aryl-heteroaryl carboxylic acid from l-bromo-4-butylbenzene and an aryl- or heteroaryl boronic acid. An illustration of this method is depicted for 4-(4-butylphenyl)benzoic acid. [00270] A solution of l-bromo-4-butylbenzene (100 g, 0.472 mol), 4- (methoxycarbonyl)phenylboronic acid (82.0 g, 0.456 mol), 2 M Na2C03 (150 g, 1.42 mol) in toluene/EtOH (900 mL/300 mL) was degassed with N2 three times, then Pd(PPh3)4 (27.2 g, 23.6 mmol) was added. The resulting mixture was degassed with N2 three times and then heated to reflux for 5 firs. After TLC showed the reaction was complete, toluene and EtOH was removed under vacuum. The residue was extracted with EA (30 mL x 3). The combined organic layers were washed with brine, dried with Na2S04. The solvent was removed to give the crude product. The crude product was purified by column chromatography on silica gel eluted with PE, PE: EA (150: 1). The solvent was removed to give methyl 4-(4-butylphenyl)benzoate (105 g, yield: 86.0%), as a white solid
86%	With tetrakis(triphenylphosphine) palladium(0); sodium carbonate; In ethanol; toluene; for 5h;Reflux;	A solution of <strong>[41492-05-1]1-bromo-4-n-butylbenzene</strong> (100 g, 0.472 mol), 4-(methoxycarbonyl)benzeneboronic acid (82.0 g, 0.46 mol), 2 M Na2CO3 (150 g, 1.42 mol) in toluene/EtOH (900 mL/300 mL) was degassed with N2 three times, then Pd(PPh3)4 (27.2 g, 23.6 mmol) was added. The resulting mixture was degassed with N2 three times and then heated to reflux for 5h. After TLC showed the reaction was complete, toluene and EtOH was removed under vacuum. The residue was extracted with EA (3x). The combined organic layers werewashed with brine and dried with Na2504. The solvent was removed to give the crude product. The crude product was purified by column chromatography on silica gel eluted with PE: EA (150:1). The solvent was removed to give methyl 4?-butyl- [1,1 ?-biphenylj -4-carboxylate (105 g, 86.0%) as a white solid.
86%	With sodium carbonate; In ethanol; water; toluene; for 5h;Inert atmosphere; Reflux;	A solution of <strong>[41492-05-1]1-bromo-4-n-butylbenzene</strong> (100 g, 0.472 mol), 4- (methoxycarbonyl)benzeneboronic acid (82.0 g, 0.456 mol), 2 M Na2CO3 (150 g, 1.42 mol) in toluene/EtOH (900 mL/300 mL) was degassed with N2 three times, then Pd(PPh3)4 (27.2 g, 23.6 mmol) was added. The resulting mixture was degassed with N2 three times and then heated to reflux for 5h. After TLC showed the reaction was complete, toluene and EtOH was removedunder vacuum. The residue was extracted with EA (3x). The combined organic layers were washed with brine and dried with Na2504. The solvent was removed to give the crude product. The crude product was purified by column chromatography on silica gel eluted with PE: EA (150:1). The solvent was removed to give methyl 4?-butyl- [1,1 ?-biphenylj -4-carboxylate (105 g, 86.0%) as a white solid.

In ethanol; toluene;

General Method 13 The synthesis of a biaryl or aryl-heteroaryl carboxylic acid from [41492-05-1]1-bromo-4-butylbenzene and an aryl- or heteroaryl boronic acid. An illustration of this method is depicted for 4-(4-butylphenyl)benzoic acid. A solution of [41492-05-1]1-bromo-4-butylbenzene (100 g, 0.472 mol), 4-(methoxycarbonyl)phenylboronic acid (82.0 g, 0.456 mol), 2 M Na2CO3 (150 g, 1.42 mol) in toluene/EtOH (900 mL/300 mL) was degassed with N2 three times, then Pd(PPh3)4 (27.2 g, 23.6 mmol) was added. The resulting mixture was degassed with N2 three times and then heated to reflux for 5 hrs. After TLC showed the reaction was complete, toluene and EtOH was removed under vacuum. The residue was extracted with EA (30 mL*3). The combined organic layers were washed with brine, dried with Na2SO4. The solvent was removed to give the crude product. The crude product was purified by column chromatography on silica gel eluted with PE, PE:EA (150:1). The solvent was removed to give methyl 4-(4-butylphenyl)benzoate (105 g, yield: 86.0%), as a white solid.

Reference： [1]Patent: WO2013/123456,2013,A1 .Location in patent: Paragraph 00269-00270
[2]Patent: WO2017/84629,2017,A1 .Location in patent: Paragraph 00340
[3]Patent: WO2017/84630,2017,A1 .Location in patent: Paragraph 00443
[4]Patent: US2013/217619,2013,A1 .Location in patent: Page/Page column

53
potassiumhexacyanoferrate(II) trihydrate [ No CAS ]
[ 41492-05-1 ]
[ 20651-73-4 ]

Yield	Reaction Conditions	Operation in experiment
88%	With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tris(2-morpholinophenyl)phosphine; potassium carbonate In water; <i>tert</i>-butyl alcohol at 85℃; for 12h; Schlenk technique; Inert atmosphere;

Reference： [1]Zou, Tao; Feng, Xiujuan; Liu, Hesong; Yu, Xiaoqiang; Yamamoto, Yoshinori; Bao, Ming [RSC Advances, 2013, vol. 3, # 43, p. 20379 - 20384]

54
[ 108-77-0 ]
[ 41492-05-1 ]
[ 1643382-76-6 ]

Yield	Reaction Conditions	Operation in experiment
43%		A solution of 4-n-butylbromobenzene (31 mL, 180 mmol, 3 eq) was added dropwise to a suspension of magnesium turnings (4.81 g, 198 mmol, 3.3 eq) in anhydrous THF (120 mL) over 30 minutes. After complete addition, the reaction mixture was maintained for2 h at reflux temperature, then cooled to room temperature. The Grignard solution was added dropwise to a solution of cyanuric chloride 1 (11.1 g, 60.0 mmol) in anhydrous THF (100 mL) while the temperature was maintained at 0 C. When the addition was completed, the mixture was stirred for 10 h at 50 C and then cooled to room temperature and poured into an aqueous solution of HCl (200 mL) to neutralize. Ethyl acetate (200 mL) was poured in the mixture. The organic phase was separated, washed three times with water, dried over anhydrous MgSO4, then concentrated and the residue was purified by silica-gel chromatography (hexane/dichloromethane = 20:1 to 5:1) to afford the title compound (9.89 g, 26.0 mmol, 43%) as a white solid.

Reference： [1]Chemistry Letters,2014,vol. 43,p. 699 - 701

55
[ 1885-46-7 ]
[ 41492-05-1 ]
[ 1454765-32-2 ]

Yield	Reaction Conditions	Operation in experiment
62%		General procedure: [a] Reactions were performed on a 0.5 mmol scale to determine yields by 19F NMR spectroscopy with PI1CF3 as an internal standard added after the reaction.; Note: The hydroxylation reaction was set-up under an inert atmosphere according to the literature procedure. [Anderson, K. W.; Ikawa, T.; Tundel, R. E.; Buchwald, S. L. J. Am. Chem. Soc. 2006, 128, 10694.] To an oven-dried 4 mL vial was added Pd2(dba)3 (9.2 mg, .010 mmol, 4.0 mol % Pd), 2-Di-tert-butylphosphino-2',4',6'-triisopropylbiphenyl (lBu- XPhos, 17.0 mg, .040 mmol, 8.0 mol %), KOH (1.0-3.0 equiv), degassed H20 (150-300 mu) and dioxane (250-500 muKappa). The aryl halide (0.5 mmol, 1.0 equiv) was added (solid aryl halides were weighed into the vial prior to adding solvent, and liquid aryl bromides were added neat by syringe after the addition of solvent). The vial was sealed with a Teflon-lined cap and heated at 100 C for 1-18 h. The solution was allowed to cool, and the reaction was diluted with acetonitrile (500-750 mu, such that the total volume of dioxane and acetonitrile is 1.0 mL) and 6M KOH (700-850 mu, such that the final aqueous solvent volume is 1.0 mL). The resulting mixture was stirred rapidly at room temperature, and HCF20Tf (210 mu, 1.5 mmol, 3.0 equiv) was added at once. Note: the reactions are exothermic. The mixture was stirred vigorously for 2 minutes. The reaction was diluted with ]0 (8 mL) and extracted with ether (2 x 8 mL). The combined organic layers were dried over MgS04, concentrated, and purified by silica gel chromatography.

Reference： [1]Patent: WO2014/107380,2014,A1 .Location in patent: Paragraph 00166-00167

56
[ 41492-05-1 ]
[ 13230-09-6 ]
1-butyl-5-(4-butylphenyl)-4-nitro-1H-imidazole [ No CAS ]
1-butyl-2,5-bis(4-butylphenyl)-4-nitro-1H-imidazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
68%; 15%Spectr.	With palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; In toluene; at 120℃; for 18h;Inert atmosphere;	General procedure: To a 8 mL glass vial equipped with a magnetic stirbar were sequentially added K2CO3 (207 mg, 1.5 mmol), the nitroazole substrate (0.50 mmol), aryl halide (0.50 mmol oras indicated), toluene (0.50 M or 1.0 M), Pd(OAc)2 (5.60mg, 0.025 mmol) and [PCy3H]BF4 (18.4 mg, 0.050 mmol).The reaction mixture was purged with nitrogen through aTeflon-lined cap. Then the cap was replaced with a newTeflon-lined solid cap. The reaction vial was moved to a preheatedreaction block. After stirring for 18 h at the indicatedtemperature, the reaction mixture was cooled to 25 C and concentrated. The residue was purified by flash column chromatography to provide the desired arylated product.

Reference： [1]Bulletin of the Korean Chemical Society,2014,vol. 35,p. 3009 - 3014

57
[ 41492-05-1 ]
[ 13230-09-6 ]
1-butyl-2,5-bis(4-butylphenyl)-4-nitro-1H-imidazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
75%	With palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; Trimethylacetic acid; In toluene; at 120℃; for 18h;Inert atmosphere;	General procedure: To a 8 mL glass vial equipped with a magnetic stirbar were sequentially added K2CO3 (207 mg, 1.5 mmol), the nitroazole substrate (0.50 mmol), aryl halide (0.50 mmol oras indicated), toluene (0.50 M or 1.0 M), Pd(OAc)2 (5.60mg, 0.025 mmol) and [PCy3H]BF4 (18.4 mg, 0.050 mmol).The reaction mixture was purged with nitrogen through aTeflon-lined cap. Then the cap was replaced with a newTeflon-lined solid cap. The reaction vial was moved to a preheatedreaction block. After stirring for 18 h at the indicatedtemperature, the reaction mixture was cooled to 25 C and concentrated. The residue was purified by flash column chromatography to provide the desired arylated product.

Reference： [1]Bulletin of the Korean Chemical Society,2014,vol. 35,p. 3009 - 3014

58
[ 41492-05-1 ]
[ 88095-61-8 ]
1-benzyl-5-(4-butylphenyl)-4-nitro-1H-pyrazole [ No CAS ]
1-benzyl-3,5-bis(4-butylphenyl)-4-nitro-1H-pyrazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85%; 7%	With palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; In toluene; at 100℃; for 18h;Inert atmosphere;	General procedure: To a 8 mL glass vial equipped with a magnetic stirbar were sequentially added K2CO3 (207 mg, 1.5 mmol), the nitroazole substrate (0.50 mmol), aryl halide (0.50 mmol oras indicated), toluene (0.50 M or 1.0 M), Pd(OAc)2 (5.60mg, 0.025 mmol) and [PCy3H]BF4 (18.4 mg, 0.050 mmol).The reaction mixture was purged with nitrogen through aTeflon-lined cap. Then the cap was replaced with a newTeflon-lined solid cap. The reaction vial was moved to a preheatedreaction block. After stirring for 18 h at the indicatedtemperature, the reaction mixture was cooled to 25 C and concentrated. The residue was purified by flash column chromatography to provide the desired arylated product.
62%; 25%	With palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; Trimethylacetic acid; In toluene; at 120℃; for 18h;Inert atmosphere;	General procedure: To a 8 mL glass vial equipped with a magnetic stirbar were sequentially added K2CO3 (207 mg, 1.5 mmol), the nitroazole substrate (0.50 mmol), aryl halide (0.50 mmol oras indicated), toluene (0.50 M or 1.0 M), Pd(OAc)2 (5.60mg, 0.025 mmol) and [PCy3H]BF4 (18.4 mg, 0.050 mmol).The reaction mixture was purged with nitrogen through aTeflon-lined cap. Then the cap was replaced with a newTeflon-lined solid cap. The reaction vial was moved to a preheatedreaction block. After stirring for 18 h at the indicatedtemperature, the reaction mixture was cooled to 25 C and concentrated. The residue was purified by flash column chromatography to provide the desired arylated product.

Reference： [1]Bulletin of the Korean Chemical Society,2014,vol. 35,p. 3009 - 3014
[2]Bulletin of the Korean Chemical Society,2014,vol. 35,p. 3009 - 3014

59
[ 41492-05-1 ]
[ 3994-50-1 ]
5-(4-butylphenyl)-1-methyl-4-nitro-1H-pyrazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
77%	With palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; In toluene; at 120℃; for 18h;Inert atmosphere;	General procedure: To a 8 mL glass vial equipped with a magnetic stirbar were sequentially added K2CO3 (207 mg, 1.5 mmol), the nitroazole substrate (0.50 mmol), aryl halide (0.50 mmol oras indicated), toluene (0.50 M or 1.0 M), Pd(OAc)2 (5.60mg, 0.025 mmol) and [PCy3H]BF4 (18.4 mg, 0.050 mmol).The reaction mixture was purged with nitrogen through aTeflon-lined cap. Then the cap was replaced with a newTeflon-lined solid cap. The reaction vial was moved to a preheatedreaction block. After stirring for 18 h at the indicatedtemperature, the reaction mixture was cooled to 25 C and concentrated. The residue was purified by flash column chromatography to provide the desired arylated product.

Reference： [1]Bulletin of the Korean Chemical Society,2014,vol. 35,p. 3009 - 3014

60
[ 41492-05-1 ]
[ 13230-13-2 ]
1-benzyl-5-(4-butylphenyl)-4-nitro-1H-imidazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
70%	With palladium diacetate; potassium carbonate; tricyclohexylphosphine tetrafluoroborate; In toluene; at 120℃; for 18h;Inert atmosphere;	General procedure: To a 8 mL glass vial equipped with a magnetic stirbar were sequentially added K2CO3 (207 mg, 1.5 mmol), the nitroazole substrate (0.50 mmol), aryl halide (0.50 mmol oras indicated), toluene (0.50 M or 1.0 M), Pd(OAc)2 (5.60mg, 0.025 mmol) and [PCy3H]BF4 (18.4 mg, 0.050 mmol).The reaction mixture was purged with nitrogen through aTeflon-lined cap. Then the cap was replaced with a newTeflon-lined solid cap. The reaction vial was moved to a preheatedreaction block. After stirring for 18 h at the indicatedtemperature, the reaction mixture was cooled to 25 C and concentrated. The residue was purified by flash column chromatography to provide the desired arylated product.

Reference： [1]Bulletin of the Korean Chemical Society,2014,vol. 35,p. 3009 - 3014

61
[ 41492-05-1 ]
C₂₄H₂₀Cl₂F₂Ir₂N₂ [ No CAS ]
[ 693-13-0 ]
C₄₁H₄₅F₂IrN₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
63%		General procedure: CS127 was prepared using a modified literature procedure [16]. A solution of butyllithium (1. hexane, 0.15 mL) was added to a solution of 4-bromotoluene (8.52 mg, 0.050 mmol) in hexane (15 mL). After stirring for 1 h, N,N'-diisopropylcarbodiimide (6.29 mg, 0.050 mmol) was added dropwise. The solution was stirred for 1 h at room temperature and then the dimer [(FMeppy)2Ir(mu-Cl)]2 (30 mg, 0.025 mmol) was added. The mixture was heated overnight at 70 C. After being cooled to room temperature, the resulting precipitate was collected and washed with diethyl ether. The dried product was obtained as a yellow powder. Yield 65%.

Reference： [1]Journal of Organometallic Chemistry,2014,vol. 772,p. 68 - 78

62
[ 691-24-7 ]
[ 41492-05-1 ]
C₂₄H₂₀Cl₂F₂Ir₂N₂ [ No CAS ]
C₄₃H₄₉F₂IrN₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
65%		General procedure: CS127 was prepared using a modified literature procedure [16]. A solution of butyllithium (1. hexane, 0.15 mL) was added to a solution of 4-bromotoluene (8.52 mg, 0.050 mmol) in hexane (15 mL). After stirring for 1 h, N,N'-diisopropylcarbodiimide (6.29 mg, 0.050 mmol) was added dropwise. The solution was stirred for 1 h at room temperature and then the dimer [(FMeppy)2Ir(mu-Cl)]2 (30 mg, 0.025 mmol) was added. The mixture was heated overnight at 70 C. After being cooled to room temperature, the resulting precipitate was collected and washed with diethyl ether. The dried product was obtained as a yellow powder. Yield 65%.

Reference： [1]Journal of Organometallic Chemistry,2014,vol. 772,p. 68 - 78

63
[ 15226-74-1 ]
[ 41492-05-1 ]
[ 107377-07-1 ]

Yield	Reaction Conditions	Operation in experiment
90%	With 1H-imidazole; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; ammonium chloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 90℃; for 3h;Sealed tube;	General procedure: To a stirred solution of aryl halide (Br/I) (1 mmol) in dry dioxane in a 25 mL sealed tube, was added Pd(OAc)2 (5 mol%), dppf (6 mol %), DIPEA (2 mmol), imidazole (0.25 mmol), ammonium chloride (2 mmol) and then Co2(CO)8 (0.3 mmol). The seal tube was closed immediately and stirred at 90 C for 3h. After the reaction time the reaction mixture was cooled to room temperature. The reaction mixture was filtered through celite pad and washed with dioxane, the filtrate was concentrated under reduced pressure and the residue obtained was purified by column chromatography.

Reference： [1]Tetrahedron Letters,2015,vol. 56,p. 4864 - 4867

64
[ 1055351-98-8 ]
[ 41492-05-1 ]
(4-butylphenyl)(3',5'-dichloro-2,6-dimethoxybiphenyl-4-yl)methanol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
87%		General procedure: Glassware and magnesium turnings were dries overnight in a110 C oven, assembled hot, and allowed to come to ambient temperatureunder dry positive nitrogen pressure. To the magnesiumturning (290 mg, 12.1 mmol) was added dry THF (12 mL), n-bromohexane(2 g, 12.1 mmol), and 1 drop of 1,2-dibromoethaneand the mixture was heated to reflux, the reaction was determinedto be complete when the magnesiumturnings were consumed. Thesolution was allowed to cool to ambient temperature then 6.5 mL(6.5 mmol) of the Grignard reagent was added dropwise to an icecold solution of 3 (1 g, 3.2 mmol) in dry THF (3.5 mL). The solutionwas allowed to warm to ambient temperature then stirred for anadditional 3 h. The reaction was quenched with saturated ammoniumchloride (15 mL), layers separated, and the aqueous phaseextracted with THF (2 15 mL), and the organic phase extractedwith brine (15 mL) then dried over sodium sulfate. Solvent wasremoved and the residue was loaded onto a Grace Reveleris 12 gsilica column and eluted with a hexane/ethyl acetate gradient(5-5% 2 column volumes, 5-40% 10 column volumes, 40-40% 2column volume, flow rate 36 mL per min).

Reference： [1]Bioorganic and Medicinal Chemistry,2015,vol. 23,p. 5390 - 5401

65
[ 41492-05-1 ]
[ 111939-57-2 ]

Yield	Reaction Conditions	Operation in experiment
38%		General procedure: A flask equippedwith a dropping funnel and a reflux condenser was charged with Mg in THF (or Et2O). Thedropping funnel was charged with the arylbromide in THF. After addition of approximately10% of the aryl bromide to the Mg, the solution was carefully heated to start the reaction.The aryl bromide was subsequently added slowly. After complete addition, the reaction wasrefluxed for 2-12 h, until complete consumption of magnesium. The content of Grignardreagent was determined by diluting small volume of the solution with deionized water andtitration with 1M HCl using phenolphthalein as indicator. The Grignard solution was slowlyadded to SiCl4 in THF (or Et2O) at 0C. The reaction was stirred for 4 h and was allowedto warm up to room temperature. The solvent was removed under reduced pressure andthe residue dissolved in boiling toluene. Insoluble salts were removed via filtration throughcellite and washed with hot toluene. The solvent of the resulting clear solution was removedunder reduced pressure, followed by purification via distillation or recrystallization. Benzyl2SiCl2 (1). Mg (2.63 g, 108 mmol, 1 equiv.) in Et2O (100 mL). Addition ofbenzylbromide (13 mL, 108 mmol, 1 equiv.) in Et2O (40 mL). 2 h reflux. SiCl4 (6 mL,52 mmol, 0.5 equiv.) in Et2O (80 mL). Purification by distillation. Crystals suitable forX-ray diffraction analysis were grown from toluene at 4C. Yield 38% (5.9 g, 21 mmol).mp = 50-51C. bp (obs.) = 103-107C (0.4 mbar).49 1H NMR (300 MHz, CDCl3): delta7.3-7.1 (m, 10H, Ar-H), 2.60 (s, 4H, Si-CH2-Ar) ppm. 13C NMR (75.5 MHz, C6D6): delta134.1, 129.4, 128.8, 126.1, 28.8 (CH2) ppm. 29Si (59.6 MHz, C6D6): delta 22.72 ppm. MS(70 eV, m/z) = 280.1 (M+).

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,2015,vol. 190,p. 1980 - 1994
[2]Journal of Photochemistry and Photobiology A: Chemistry,2016,vol. 331,p. 120 - 129

66
[ 41492-05-1 ]
[ 20651-67-6 ]

Yield	Reaction Conditions	Operation in experiment
90%	With copper(I) oxide; L-proline; potassium iodide; In ethanol; at 110℃; for 30h;Schlenk technique; Inert atmosphere; Sealed tube;	General procedure: A Schlenk tube was charged with Cu2O (7.2 mg, 10 mol%), l-proline (11.5 mg, 20 mol%), aryl (or heteroaryl) bromide (1 or 3,0.50 mmol), potassium iodide (KI) (249 mg, 0.75 mmol), and EtOH(1.5 mL) under nitrogen atmosphere. The Schlenk tube was sealedwith a teflon valve, and then the reaction mixture was stirred at110C for a period (the reaction progress was monitored by GCanalysis). After the reaction was completed, GC yield of high volatileproduct was determined using an appropriate internal standard(chlorobenzene or 1-chloro-4-methylbenzene) or the solvent wasremoved under reduced pressure. The residue obtained was puri-fied via silica gel chromatography (eluent: petroleum ether/ethylacetate = 10/1) to afford aryl iodides 2a-2o or heteroaryl iodides4a-4g.

Reference： [1]Catalysis Today,2016,vol. 274,p. 129 - 132

67
[ 3612-20-2 ]
[ 41492-05-1 ]
1-benzyl-4-(4-butylphenyl)piperidin-4-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
68%		[009831 To a stirring solution of 1-brorno-4-butylbenzene (3.72 g, 17.44 mrnol) in THF (50 mL) at -78C was added butyllithium (7.61 mL of a 2.5 M solution in hexanes, 19.02 mmol). After 1 h. 1-benzylpiperidin-4-one (2.94 mL, 15.85 mmol) was added. The reaction was stirred at -78C for 1 h, then warmed to room temperature and stirred for a further 1 h. The reaction was quenched with ammonium chloride (30 mL of a saturated aqueous solution) and extracted with EA (3 x 3OmL). The combined organic extracts were washed with brine (30 mL), dried over MgSO4 and solvents evaporated to afford 3.5 g (68%) of l-benzyl-4-(4-butylphenyl)piperidin-4-ol. LCMS-ESI (m/z) calculated for C22H29N0: 323.2; found 324.3 [M+H, tR = 1.51 mm (Method]]).

Reference： [1]Patent: WO2016/94729,2016,A1 .Location in patent: Paragraph 00983

68
[ 753-90-2 ]
[ 41492-05-1 ]
C₁₂H₁₆F₃N [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
81%	With (2R)-1-[(1R)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(dicyclohexylphosphino)ferrocene; palladium diacetate; sodium t-butanolate; In 1,4-dioxane; at 100℃; for 15h;Sealed tube; Glovebox;	Due to the similar basicity of trifluoroethylamine and aniline, it was hypothesized that trifluoroethylamine would couple with aryl halides under conditions reported for the coupling of aniline with aryl halides. To test this hypothesis, trifluoroethylamine was allowed to react with 4-n-butyl bromobenzene in the presence of a Josiphos-ligated catalyst that couples anilines with aryl halides with broad scope under mild conditions. Figure 2A shows a chemical reaction forthe coupling of trifluoroethylamine 202 with aryl bromides 201. The reaction is catalyzed with1 mole percent of Pd(OAc)2 and 1 mole percent of CyPFtBu, with 1.4 equivalents of NaOtBu and dioxane at 100C where the aryl bromide 201 is provided at 1.2 equivalents. The product is depicted in compound 203. Figure 2B shows the chemical structure of CyPFtBu. Organic groups R for 201 and 203 of Figure 2A may be any of the below structures as shown in Table 1.The results are shown in Table 1. In one trial, the reaction produced compound 401 in 81% yield after 15 hours. Compound 401 is shown below and is also depicted in Figure 3B:

Reference： [1]Patent: WO2016/183101,2016,A1 .Location in patent: Page/Page column 0055; 0056; 0058; 0061

69
[ 41492-05-1 ]
[ 113443-62-2 ]
(4-butylphenyl)(naphthalen-2-yl)methanone [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2017,vol. 139,p. 1416 - 1419

70
[ 41492-05-1 ]
C₁₅H₁₀N^(1-)*Li⁽¹⁺⁾ [ No CAS ]
C₂₅H₂₃N [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
75.7%	With bis(triphenylphosphine)nickel(II) chloride; In toluene; at 20 - 110℃; for 13h;Inert atmosphere;	Placed in a 100 ml three-necked flask with magnetic stirring,0.07 mmol of triphenylphosphine nickel chloride was added,1.0 mmol of the compound of formula III,Vacuum for N2 gas 3 times,Add 15 ml of anhydrous toluene,To the syringe was added 1.2 mmol of the compound of the above formula IV,The mixture was stirred at room temperature for 1 hour,And then heated to 110 C to continue the reaction for 12 hours,Stop the reaction.After the reaction,The reaction system was naturally cooled to room temperature,Filtered through a silica gel layer,A dark brown reaction solution,Washed with ethyl acetate,Organic synthesis.The organic phase was dried over anhydrous magnesium sulfate,Filter, concentrate,Silica gel column chromatography (silica gel 200-300 mesh; petroleum ether / dichloromethane = 15: 1, v / v)Get 255 mg product,I.e., the compound I of the above formula (yield: 75.7%).

Reference： [1]Patent: CN106905224,2017,A .Location in patent: Paragraph 0115; 0116; 0117; 0118; 0119

71
[ 41492-05-1 ]
C₁₅H₁₀N^(1-)*Li⁽¹⁺⁾ [ No CAS ]
C₂₅H₂₃N [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	With bis(triphenylphosphine)nickel(II) chloride; In toluene; at 20 - 110℃; for 11h;Inert atmosphere;	A 100 ml three-necked flask equipped with a magnetic stirrer was charged with 0.05 millimole of triphenylphosphine nickel chloride and 1.0 millimole of compound III of the above formula, evacuated for 3 times with N2 gas, 15 ml of anhydrous toluene was added, and a syringe was charged 1.2 mmol of the compound IV of the above formula was added and stirred at room temperature for 1 hour and then heated to 110 C to continue the reaction for 10 hours to stop the reaction.After the reaction was completed, the reaction system was allowed to cool to room temperature and filtered through a pad of silica gel to give a dark brown reaction mixture, which was washed with ethyl acetate and the organic phases were combined.The organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated. Silica gel column chromatography (silica gel 200-300 mesh; petroleum ether / methylene chloride = 15: 1, v / v) afforded 242 mg of product, (72% yield).

Reference： [1]Patent: CN106905223,2017,A .Location in patent: Paragraph 0142; 0143; 0144; 0145

72
[ 1279123-63-5 ]
[ 55124-35-1 ]
[ 41492-05-1 ]
[ 1412414-09-5 ]

Yield	Reaction Conditions	Operation in experiment
85%		General procedure: A solution in THF (4 mL) of DIPAB (863 mg, 7.5 mmol), Mg (182 mg, 7.5 mmol) and arylbromide (5 mmol) was stirred at 70 C until no starting arylbromide remains (TLC). The reaction mixture was cooled down to 0 C and quenched slowly with 7 mL of MeOH. After 1h, volatile were removed under reduced pressure and the resulting solid was dissolved in MeOH. An aqueous solution of KHF2 (4.5 eq, 10 mL) was added at room temperature. After 1h at room temperature, volatiles were removed under reduced pressure; the solid was extracted with anhydrous acetone and the resulting powder was recrystallized from acetone/Et2O or acetone/pentane.

Reference： [1]Tetrahedron,2019,vol. 75,p. 164 - 171

73
[ 67-56-1 ]
[ 55124-35-1 ]
[ 41492-05-1 ]
[ 145240-28-4 ]

Yield	Reaction Conditions	Operation in experiment
92%		General procedure: To a solution in THF (4 mL) of DIPAB (863 mg, 7.5 mmol) and Mg (182 mg, 7.5 mmol) were added a PhMgBr 1M THF solution (375 muL, 375mumol) at room temperature. After 10 min, 30 mL of anhydrous THF were added followed by the arylbromide (5 mmol). The reaction mixture was cooled down to 0 C and quenched slowly with 7 mL of MeOH. After 1h, volatile were removed under reduced pressure and the resulting solid was dissolved in 1N HCl/MeOH (7/3). After 1h at room temperature, 100 mL of AcOEt were added, the organic phase was washed with 1N HCl (30 mL) and brine (3×30 mL). Organic phases were concentrated under reduced pressure yielding a solid which was recrystallized from H2O.

Reference： [1]Tetrahedron,2019,vol. 75,p. 164 - 171

74
[ 67-56-1 ]
[ 131765-96-3 ]
[ 41492-05-1 ]
[ 145240-28-4 ]

Yield	Reaction Conditions	Operation in experiment
99%		General procedure: A solution in THF (4 mL) of DIPAB (863 mg, 7.5 mmol), Mg (182 mg, 7.5 mmol) and arylbromide (5 mmol) was stirred at 70 C until no starting arylbromide remains (TLC). The reaction mixture was cooled down to 0 C and quenched slowly with 7 mL of MeOH. After 1h, volatile were removed under reduced pressure and the resulting solid was dissolved in 1N HCl/MeOH (7/3). After 1h at room temperature, 100 mL of AcOEt were added, the organic phase was washed with 1N HCl (30 mL) and brine (3×30 mL). Organic phases were concentrated under reduced pressure yielding a solid which was recrystallized from H2O.

Reference： [1]Tetrahedron,2019,vol. 75,p. 164 - 171

75
[ 41492-05-1 ]
[ 75-05-8 ]
[ 20651-73-4 ]

Yield	Reaction Conditions	Operation in experiment
84%	With 1,10-Phenanthroline; hexakis(acetonitrile)nickel(II) tetrafluoroborate; 2,3,5,6-tetramethyl-1,4-bis(trimethylsilyl)-1,4-diaza-2,5-cyclo-hexadiene at 80℃; for 24h;

Reference： [1]Ueda, Yohei; Tsujimoto, Nagataka; Yurino, Taiga; Tsurugi, Hayato; Mashima, Kazushi [Chemical Science, 2019, vol. 10, # 4, p. 994 - 999]

76
[ 225931-80-6 ]
[ 1160861-53-9 ]
[ 41492-05-1 ]
C₄₁H₆₂BrO₂PPd [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2019,vol. 84,p. 12672 - 12679

77
[ 87-82-1 ]
[ 41492-05-1 ]
1,4-diiodo-2,3,5,6-tetrakis(4-butylphenyl)benzene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
49%	Stage #1: p-bromobutylbenzene With magnesium In tetrahydrofuran at 20℃; for 2h; Cooling with ice; Stage #2: hexabromobenzene In tetrahydrofuran at 20℃; for 22h; Stage #3: With iodine In tetrahydrofuran for 0.25h;

Reference： [1]Nishimura, Tomoaki; Sasaki, Yoshito; Tachi, Yoshimitsu; Suzuki, Shuichi; Okada, Keiji; Kozaki, Masatoshi [Chemistry - An Asian Journal, 2020, vol. 15, # 5, p. 594 - 600]

78
[ 41492-05-1 ]
[ 4931-66-2 ]
(S)-5-[bis(4-butylphenyl)(hydroxy)methyl]pyrrolidin-2-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
4.05 g	Stage #1: p-bromobutylbenzene With iodine; magnesium In tetrahydrofuran at 0℃; for 3.5h; Inert atmosphere; Schlenk technique; Reflux; Stage #2: methyl (S)-pyroglutamate In tetrahydrofuran at 0 - 20℃; Inert atmosphere; Schlenk technique;	(S)-5-[Bis(4-butylphenyl)(hydroxy)methyl]pyrrolidin-2-one (3d) A dry, argon-flushed, two-neck Schlenk flask equipped with a magnetic stir bar and a septum was charged with methyl pyroglutamate 2 (3.5 g, 24.5 mmol, 1 equiv) in anhydrous THF (50 mL). 4-n-Butylphenylmagnesium bromide (110.0 mL, 73 mmol, 0.67 M in THF, 3.0 equiv) was added dropwise at 0 °C and the mixture warmed to 20 °C and left to stir for 24 h. The reaction mixture was quenched with 3% aqueous HCl solution (300 mL). The organic layer was removed, and the aqueous layer was washed with DCM (5 × 50 mL). The organic extracts were combined, dried over Na2SO4 and concentrated under reduced pressure. The obtained crude residue was purified by flash column chromatography (silica gel was pre-neutralized with triethylamine, n-hexane/EtOAc, 1:9) to furnish compound 3d. Yield: 4.05 g (56%); white solid.1H NMR (400 MHz, CD3OD): = 0.89-0.94 (m, 6 H), 1.28-1.39 (m, 4H), 1.52-1.61 (m, 4 H), 1.96-2.12 (m, 4 H), 2.54-2.60 (m, 4 H), 4.76-4.79 (m, 1 H), 4.85 (s, 1 H), 7.09-7.16 (m, 4 H), 7.31-7.34 (m, 2 H),7.38-7.41 (m, 2 H).13C NMR (100 MHz, CD3OD): = 14.3, 23.2, 23.3, 31.1, 34.8, 36.1, 62.4,80.1, 127.6, 129.0, 129.3, 142.7, 142.9, 143.1, 143.9, 181.9.

Reference： [1]Dhayalan, Vasudevan; Mal, Kanchan; Milo, Anat [Synthesis, 2019, vol. 51, # 14, p. 2845 - 2864]

79
[ 2768-02-7 ]
[ 41492-05-1 ]
[ 26206-42-8 ]

Yield	Reaction Conditions	Operation in experiment
56%	With (1,2-dimethoxyethane)dichloronickel(II); tetrabutylammonium triphenyldifluorosilicate In N,N-dimethyl acetamide at 35℃; for 12h; Inert atmosphere;	General Procedure 2 General procedure: In a nitrogen-filled glove box, aromatic halide (0.2 mmol, 1.0equiv), TBAT (270 mg, 0.5 mmol, 2.5 equiv), NiCl2(glyme) (4.4mg, 0.02 mmol, 10 mol%), and DMA (1.0 mL) were charged to an8 mL vial equipped with a magnetic stirrer bar. The vinyltrimethoxysilane(59.1 mg, 0.4 mmol, 2.0 equiv) was added. The vialwas removed from the glove box, and the reaction mixture wasstirred at rt (35 °C) for 12 h. The reaction mixture was thendiluted with EtOAc and washed with water. The organic phasewas dried over Na2SO4, filtered, and concentrated, and theresidue was purified by column chromatography on silica gel togive the product.

Reference： [1]Wei, Shichao; Mao, Yongjun; Shi, Shi-Liang [Synlett, 2021, vol. 32, # 16, p. 1670 - 1674]

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[ CAS No. 41492-05-1 ] {[proInfo.proName]}

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[ 41492-05-1 ] Synthesis Path-Upstream 1~5

[ 41492-05-1 ] Synthesis Path-Downstream 1~79

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