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Chemical Structure| 41284-92-8 Chemical Structure| 41284-92-8

Structure of 41284-92-8

Chemical Structure| 41284-92-8

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Product Details of [ 41284-92-8 ]

CAS No. :41284-92-8
Formula : C8H5IO2
M.W : 260.03
SMILES Code : O=C1OCC2=C1C=CC(I)=C2
MDL No. :N/A

Safety of [ 41284-92-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 41284-92-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 41284-92-8 ]

[ 41284-92-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 41284-92-8 ]
  • Zn(CN)2 [ No CAS ]
  • [ 82104-74-3 ]
YieldReaction ConditionsOperation in experiment
tetrakis(triphenylphosphine)palladium (0); In N,N-dimethyl-formamide; Example 4 A mixture of Zn(CN)2 (2.4 g, 0.02 mol) and 5-iodo-3H-isobenzofuran-1-one (5.24 g, 0.02 mol) in DMF (80 mL) were stirred at room temperature under an atmosphere of argon for 30 minutes. Then dissolved oxygen was removed by bubbling argon through the reaction mixture for 10 minutes before the addition of tetrakis(triphenylphosphine)palladium (0) (1.2 g, 0.00096 mol). Then the reaction was heated at 75° C. for 3 hrs, and then the solvent was removed under reduce pressure and the residue poured into water (150 mL). Filtration and followed by drying in vacuo give the crude 5-cyano-3H-isobenzofuran-1-one (2.4 g) (HPLC 93percent).
 

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