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Chemical Structure| 4124-31-6 Chemical Structure| 4124-31-6

Structure of 4124-31-6

Chemical Structure| 4124-31-6

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Product Details of [ 4124-31-6 ]

CAS No. :4124-31-6
Formula : C4Cl6O3
M.W : 308.76
SMILES Code : O=C(OC(C(Cl)(Cl)Cl)=O)C(Cl)(Cl)Cl
MDL No. :MFCD00000793
InChI Key :MEFKFJOEVLUFAY-UHFFFAOYSA-N
Pubchem ID :20079

Safety of [ 4124-31-6 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H290-H302-H314
Precautionary Statements:P264-P270-P280-P301+P312-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P321-P363-P405-P501
Class:8
UN#:3265
Packing Group:

Application In Synthesis of [ 4124-31-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4124-31-6 ]

[ 4124-31-6 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 562-74-3 ]
  • [ 4124-31-6 ]
  • 4-Carvomenthyl trichloroacetate [ No CAS ]
  • 2
  • [ 4389-45-1 ]
  • [ 4124-31-6 ]
  • [ 66176-17-8 ]
YieldReaction ConditionsOperation in experiment
In tetrahydrofuran; at -10 - 25℃; for 19h; A pre-dried glass lined reactor was charged with triphosgene (1 wt. , 1 eq. ) and anhydrous THF (2 vol. ) and was cooled to an internal temperature of -10 C. A second pre- dried glass lined was charged with ER-807244 (1.27 wt. , 2.5 eq. ) and anhydrous THF (3 vol.) then cooled to an internal temperature of -10 C. The contents of the first reactor were transferred into the second reactor at a rate such that internal temperature did not exceed 15 C. After complete addition, the reaction was stirred at an internal temperature of 0C for 1 hour and then gradually warmed to 25C. A sparge of nitrogen was used for 18 hours to scrub away excess phosgene with trapping of the off-gases through a 2 N NaOH solution. MTBE (3 vol. ) was added and the solvent removed by distillation under N2 purge at 40 to 46C, adding more MTBE as needed. Upon complete removal of the phosgene, the mixture was cooled to an internal temperature of 5 to 10C and the solution filtered with MTBE (3 vol. ) washes to yield ER-807245 (1.12 wt. , 0.97 eq. ) as a white crystalline solid.
  • 3
  • [ 20605-41-8 ]
  • [ 4124-31-6 ]
  • [ 1178972-92-3 ]
 

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