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Chemical Structure| 40517-43-9 Chemical Structure| 40517-43-9
Chemical Structure| 40517-43-9

1-(Chloromethyl)-4-(methylsulfonyl)benzene

CAS No.: 40517-43-9

4.5 *For Research Use Only !

Cat. No.: A620582 Purity: 98%

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Product Details of [ 40517-43-9 ]

CAS No. :40517-43-9
Formula : C8H9ClO2S
M.W : 204.67
SMILES Code : O=S(C1=CC=C(C=C1)CCl)(C)=O
MDL No. :MFCD00079774

Safety of [ 40517-43-9 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P321-P363-P405-P501
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 40517-43-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 40517-43-9 ]

[ 40517-43-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 40517-43-9 ]
  • [ 581060-27-7 ]
  • [ 718610-85-6 ]
YieldReaction ConditionsOperation in experiment
Step 3 Preparation of [ (N-BOC-PIPERIDIN-4-YL) METHYL]- (4-METHANESULPHONYL- PHENYLMETHYL) sulphide N-Boc-piperidin-4-ylmethylthiol (1.155 g) was added to a suspension of sodium hydride (200 mg of a 60% dispersion in mineral oil) in DMF at 0C and the mixture was stirred for 30 minutes. 4-METHANESULPHONYLBENZYL chloride (1.023 g) was added, the reaction mixture was allowed to warm to room temperature and was stirred for 1 hour. The reaction mixture was evaporated to dryness and the residue was dissolved in dichloromethane (30 ml) and washed with water (25 ml) and brine (25 ml) and dried. The solvent was evaporated and the residue was purified on a 50g silica Bond Elut eluting with a solvent gradient (isohexane- 50% ethyl ACETATE/ISOHEXANE). Yield LG, MH 300. NMR (CDC13) : 1.2 (m, 2H), 1.45 (s, 9H), 1.5 (m, 1H), 1.8 (m, 2H), 2.35 (d, 2H), 2.65 (bt, 2H), 3.05 (s, 3H), 3.75 (s, 3H), 4.1 (m, 2H), 7.5 (d, 2H), 7.9 (d, 2H).
  • 2
  • [ 40517-43-9 ]
  • [ 122794-99-4 ]
  • C20H18BrNO5S [ No CAS ]
YieldReaction ConditionsOperation in experiment
82% With potassium carbonate; In N,N-dimethyl-formamide; at 90℃; for 4h; To the quinoline compound shown above (2.94 g, 10 mmol) in DMF (60 mL) wasadded K2C03 (5.5 g, 40 mmol) followed by 4-chloromethylmethlsulfone (Fluorochem) (2.04 g, 10 mmol) and the reaction mixture heated to 900 for 4 h. The DMF was removed on a rotary evaporator (1 mm Hg) and water (200 mL) and ethyl acetate (100 mL) added. The mixture was stirred for 30 mins and the light grey solid product filtered off and washed with ethyl acetate (100 mL). 3.58 g, 82 %.
 

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