Structure of 40499-83-0
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CAS No. : | 40499-83-0 |
Formula : | C4H9NO |
M.W : | 87.12 |
SMILES Code : | OC1CNCC1 |
MDL No. : | MFCD00005256 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Num. heavy atoms | 6 |
Num. arom. heavy atoms | 0 |
Fraction Csp3 | 1.0 |
Num. rotatable bonds | 0 |
Num. H-bond acceptors | 2.0 |
Num. H-bond donors | 2.0 |
Molar Refractivity | 27.11 |
TPSA ? Topological Polar Surface Area: Calculated from |
32.26 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from |
1.2 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by |
-0.69 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from |
-1.04 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from |
-0.57 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by |
0.52 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions |
-0.12 |
Log S (ESOL):? ESOL: Topological method implemented from |
0.05 |
Solubility | 98.8 mg/ml ; 1.13 mol/l |
Class? Solubility class: Log S scale |
Highly soluble |
Log S (Ali)? Ali: Topological method implemented from |
0.49 |
Solubility | 268.0 mg/ml ; 3.07 mol/l |
Class? Solubility class: Log S scale |
Highly soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by |
-0.13 |
Solubility | 64.4 mg/ml ; 0.74 mol/l |
Class? Solubility class: Log S scale |
Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg |
Low |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg |
No |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) |
No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) |
No |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) |
No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) |
No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) |
No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) |
No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from |
-7.32 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from |
0.0 |
Ghose? Ghose filter: implemented from |
None |
Veber? Veber (GSK) filter: implemented from |
0.0 |
Egan? Egan (Pharmacia) filter: implemented from |
0.0 |
Muegge? Muegge (Bayer) filter: implemented from |
2.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat |
0.55 |
PAINS? Pan Assay Interference Structures: implemented from |
0.0 alert |
Brenk? Structural Alert: implemented from |
0.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from |
No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) |
1.25 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With potassium carbonate; In dimethyl sulfoxide; at 136℃; for 7h; | Example 31a; 7V-(2-Amino-5-(5-chlorothiophen-2-yl)phenyl)-4-(3-morpholinopyrrolidin-l-yl)benzamide(271); Ste 1 : tert-Butyi 4-(3-hvdroxypyrrolidin-l-yl)benzoate (266); [0900] A mixture of fluoride 97 (2.24 g, 11.4 mmol), pyrrolidin-3-ol (1.37 g, 15.8 mmol) and potassium carbonate (2.24 g) was suspended in dimethyl sulfoxide (5 mL) and stirred at 136 0C for 7 h. The reaction mixture was cooled to room temperature, diluted with DCM, washed with H2O, dried over MgSO4, filtered and concentrated to provide title compound 266 (3.93 g, 100%). <n="152"/>[0901] LRMS: 263.3 (calc) 264.1 (obs) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
57% | With triethylamine; In dichloromethane; at 20℃; for 12h; | To a solution of pyrrolidin-3-ol (10.45 g, 120.1 mmol) in dichloromethane (300 mL) was added benzyl chloroformate (24.6 g, 144 mmol) and triethylamine (24.3 g, 240.2 mmol). The resulting solution was stirred at room temperature for 12 hours. After concentrating the reaction, the remaining material was partitioned between ethyl acetate (100 mL) and water (60 mL). The layers were separated. The organic layer was washed with water (60 mL), aqueous saturated sodium chloride solution (60 mL), dried and concentrated. The residue was purified by silica gel column chromatography (petroleum ether:ethyl acetate 2:1) to give benzyl 3-hydroxypyrrolidinyl-1-carboxylate (15.2 g, 57%) as a colorless gum. LCMS m/z = 222.1 [M+H]+. |
49% | In dichloromethane; for 20h; | Prbetaparatlon 16; S-Hydroxy-pyrrolldlne-i-carboxyllc acid benzyl ester; 3-Pyrrolidi?ol (6.99g, 68.9 mmol), benzyl chloroformata (10.66 mL, 75.8 mmol) and CH2CI2 (200 mL) were stirred for 2Oh then washed with water and brine, dried (MgSO4) and concentrated to give a thick yellow oil. Chromatography, flushing first with 20% EtOAc/ hexa?es then eluting with 30% MeOH/EtOAc, afforded 7.4Og (49%) of the title compound: NMR (CDCI3) delta 7.35-7.26 (m, 5H), 5.11 (s, 2H), 4.46 (br s, 1H), 3.60-3.38 (m, 4H)1 2.00-2.82 (m, 2H). |
8.87 g (81%) | In potassium hydroxide; | A. A solution of 4.29 g (48.9 mmol) of 3-hydroxypyrrolidine in 30 mL of 2N potassium hydroxide was cooled to 0 C. and 10.2 mL of benzyl chloroformate were added with stirring. The reaction was stirred for four hours at 0 C. and then extracted with ethyl acetate (3*100 mL). The extracts were combined, washed with brine, dried over sodium sulfate, filtered, and concentrated in vacua. The residue was chromatographed on silica gel with 70/30 hexanes/ethyl acetate. The correct fractions were combined and concentrated in vacuo to give 8.87 g (81%) of benzyl 3-hydroxypyrrolidine-1-carboxylate as a viscous clear oil. Rf=0.11 in 50/50 hexanes/ethyl acetate Mass Spectrum (FD+): M+221; IR (CHCl3, cm-1): 913, 977, 993, 1100, 1117, 1175, 1236, 1360, 1427, 1454, 1498, 1694, 2884, 2954, 3013, 3020, 3436 (broad), 3610; UV (C2 H5 OH) lambdamax =205 (epsilon=9112), 264 (epsilon=142); 1 H NMR (300 MHz, CDC13) delta: 1.91-2.05 (m-, 2H); 3.00 (broad s, 1H); 3.39-3.61 (m, 4H); 4.41 (s, 1H); 5.12 (s, 2H); 7.30-7.43 (m, 5H). |
8.87 g (81%) | In potassium hydroxide; | A. A solution of 4.29 g (48.9 mmol) of 3-hydroxypyrrolidine in 30 mL of 2N potassium hydroxide was cooled to 0C and 10.2 mL of benzyl chloroformate were added with stirring. The reaction was stirred for four hours at 0C and then extracted with ethyl acetate (3 x 100 mL). The extracts were combined, washed with brine, dried over sodium sulfate, filtered, and concentrated in vacuo. The residue was chromatographed on silica gel with 70/30 hexanes/ethyl acetate. The correct fractions were combined and concentrated in vacinoto give 8.87 g (81%) of benzyl 3-hydroxypyrrolidine-1-carboxylate as a viscous clear oil. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | (a) 3-Hydroxy-pyrrolidine-1-carboxylic acid benzyl ester. 3-Hydroxy-pyrrolidine (10 g, 115 mmol, 1.0 equiv) was dissolved in 2 N NaOH (100 mL) and the mixture was cooled to 0 C. Benzylchloroformate (21 g, 126 mmol, 1.1 equiv) was added dropwise over a 45 min period. After addition, the reaction was stirred at room temperature for 4 h at which time the pH was adjusted to 7-8 using concentrated HCl. The product was extracted with 3*100 mL of CH2Cl2. The organic extracts were combined and dried over Na2SO4, decanted and concentrated in vacuo to yield the desired product as a light yellow oil (24.1 g, 95%) that was used without further purification. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine; In aqueous hydrofluoroboric acid; diethyl ether; dimethyl sulfoxide; | EXAMPLE 27 1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-hydroxy-1-pyrrolidinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid [Steps (A2), (A3)+(A4)] A suspension of 0.50 g (0.0015 mole) of ethyl 1-cyclopropyl-6,7-difluoro-8-methoxy-1,4-dihydro-4-oxoquinoline-3-carboxylate (XXXII) (prepared as described in Preparation 3) in 10 ml of 42% aqueous hydrofluoroboric acid was stirred at 90-100 C. for 3 hours, and then poured into water to precipitate a crystalline substance. This crystalline substance was collected by filtration to afford 0.55 g of the chelate (IV) as a colorless powder. The whole of this chelate was dissolved in 2.5 ml of dimethyl sulfoxide, and 0.52 g (0.006 mole) of 3-hydroxypyrrolidine was added to the resulting solution. The mixture was then allowed to stand at room temperature overnight. At the end of this time, the reaction mixture was poured into 250 ml of diethyl ether to precipitate yellow crystals, which were collected by filtration. The whole of these crystals was dissolved in a mixture of 150 ml of 80% aqueous ethanol and 25 ml of triethylamine, and the solution was heated under reflux for 4 hours. The solution was then cooled to room temperature, insoluble material was removed by filtration, and the filtrate was concentrated by evaporation under reduced pressure to yield a crystalline substance, which was washed with ethanol. The crude crystals thus obtained were recrystallized from a mixture of methanol and water to afford 0.35 g of 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-hydroxy-1-pyrrolidinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid as pale brown needles melting at 253-254 C. Mass Spectrum: m/e 362 (M+), 318 (M+ -CO2). Elemental analysis: Calculated for C18 H19 FN2 O5: C, 59.67%; H, 5.25%; N, 7.73%. Found: C, 59.74%; H, 5.30%; N, 7.72%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
47% | With sodium hydroxide; In tetrahydrofuran; water; at 20℃; for 3h; | To the solution of pyrrolidin-3-ol (1.0 g, 11 mmol) in THF (5 mL) and 1M NaOH (5 mL) was added dibenzyldicarbonate (3.3, 11 mmol) at room temperature. The reaction mixture was stirred for 3 h then the THF removed under reduced pressure. The residue was dissolved in DCM (50 mL) and washed successively with saturated NaHCO3 (2×20mL) and saturated NaCl (2×20 mL). The solution was dried over Na2SO4, decanted and concentrated. Benzyl 3-hydroxypyrrolidine-1-carboxylate (1.1 g, 47%) was isolated by prep. HPLC YMC ODSA 30×100 mm, 20-100% MeOH/H2O (0. 1% TFA) gradient over 10 mins at 20 mL/min flow rate at a retention time of 4.93 min. LCMS: 1.21 min [M+1] 222.06 (2 min gradient, MeOH/H2O 0.1% TFA). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In dichloromethane; at 23℃; for 15h; | A solution of 33.43 mmol of (R)-(+)-3-pyrrolininol in 30 ml_ of CH2CI2 is added to a solution of 33.43 mmol of C-(bis-benzothazol-1 -yl)-methylene amine [28992-50-9] in 180 ml_ of CH2CI2. The reaction mixture is stirred at RT for 15 h, washed with aqueous 10% NaHCO3 (2 x 75 ml_), dried over Na2SO4, filtered and evaporated to afford the title compound as an orange oil. LC-MS: 232 (M+H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
100% | With caesium carbonate;palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 90℃; for 16h;Inert atmosphere; | Reference Example 71 1-[3-fluoro-5-(trifluoromethyl)phenyl]pyrrolidin-3-ol; A solution of <strong>[130723-13-6]1-bromo-3-fluoro-5-(trifluoromethyl)benzene</strong> (10.0 g), 3-hydroxypyrrolidine (3.58 g), palladium(II) acetate (461 mg), (+/-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (2.56 g) and cesium carbonate (26.7 g) in toluene (222 mL) was stirred under an argon gas atmosphere at 90C for 16 hr. After cooling to room temperature, the reaction mixture was filtered through celite, and the celite was washed with ethyl acetate. The filtrate and washing were combined and the solution was washed with water and saturated brine. This was dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate 98:2 - 20:80) to give the title compound (10.65 g, yield quant.) as a brown oil. 1H-NMR (300 MHz, CDCl3)delta:1.73 (br. s, 1 H), 2.05 - 2.28 (m, 2 H), 3.27 (d, J = 10.6 Hz, 1 H), 3.38 (td, J = 8.9, 3.4 Hz, 1 H), 3.45 - 3.59 (m, 2 H), 4.55 - 4.70 (m, 1 H), 6.35 (dt, J = 11.7, 2.3 Hz, 1 H), 6.52 (s, 1 H), 6.60 (d, J=8.7 Hz, 1 H). |
100% | With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;palladium diacetate; In toluene; at 90℃; for 16h;Inert atmosphere; | A solution of <strong>[130723-13-6]1-bromo-3-fluoro-5-(trifluoromethyl)benzene</strong> (10.0 g), 3-hydroxypyrrolidine (3.58 g), palladium(II) acetate (461 mg), (+/-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (2.56 g) and cesium carbonate (26.7 g) in toluene (222 ml) was stirred under an argon gas atmosphere at 90 C. for 16 hr. After cooling to room temperature, the reaction mixture was filtered through celite, and the celite was washed with ethyl acetate. The filtrate and washing were combined and the solution was washed with water and saturated brine. This was dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate 98:2-20:80) to give the title compound (10.65 g, yield quant.) as a brown oil.1H-NMR (300 MHz, CDCl3) delta: 1.73 (br. s, 1H), 2.05-2.28 (m, 2H), 3.27 (d, J=10.6 Hz, 1H), 3.38 (td, J=8.9, 3.4 Hz, 1H), 3.45-3.59 (m, 2H), 4.55-4.70 (m, 1H), 6.35 (dt, J=11.7, 2.3 Hz, 1 H), 6.52 (s, 1H), 6.60 (d, J=8.7 Hz, 1H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91% | With caesium carbonate;palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 80℃; for 16.0h;Inert atmosphere; | Reference Example 30 1-[2,5-bis(trifluoromethyl)phenyl]pyrrolidin-3-ol; A solution of <strong>[7617-93-8]2,5-bis(trifluoromethyl)phenyl bromide</strong> (4.45 g), 3-hydroxypyrrolidine (1.2 g), palladium(II) acetate (0.16 g), (+/-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (0.87 g) and cesium carbonate (13.6 g) in toluene (74 mL) was stirred under an argon gas atmosphere at 80C for 16 hr. The reaction mixture was allowed to cool to room temperature, water was added, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated, and the residue was purified by silica gel column chromatography (hexane:ethyl acetate 90:10 - 75:25) to give the title compound (3.79 g, yield 91%) as an orange oil. 1H-NMR (300 MHz, CDCl3)delta:1.72 (d, J = 4.9 Hz, 1 H), 1.95 - 2.10 (m, 1 H), 2.10 - 2.24 (m, 1 H), 3.21 - 3.43 (m, 2 H), 3.60 - 3.78 (m, 2 H), 4.48 - 4.65 (m, 1 H), 7.01 - 7.16 (m, 1 H), 7.16 - 7.23 (m, 1 H), 7.63 - 7.74 (m, 1 H). |
91% | With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;palladium diacetate; In 1,4-dioxane; toluene; at 80℃; for 16.0h;Inert atmosphere; | A solution of <strong>[7617-93-8]2,5-bis(trifluoromethyl)phenyl bromide</strong> (4.45 g), 3-hydroxypyrrolidine (1.2 g), palladium(II) acetate (0.16 g), (+/-)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl (0.87 g) and cesium carbonate (13.6 g) in toluene (74 mL) was stirred under an argon gas atmosphere at 80 C. for 16 hr. The reaction mixture was allowed to cool to room temperature, water was added, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated, and the residue was purified by silica gel column chromatography (hexane:ethyl acetate 90:10-75:25) to give the title compound (3.79 g, yield 91%) as an orange oil.1H-NMR (300 MHz, CDCl3) delta: 1.72 (d, J=4.9 Hz, 1H), 1.95-2.10 (m, 1 H), 2.10-2.24 (m, 1H), 3.21-3.43 (m, 2H), 3.60-3.78 (m, 2H), 4.48-4.65 (m, 1H), 7.01-7.16 (m, 1H), 7.16-7.23. (m, 1H), 7.63-7.74 (m, 1H). |
Tags: 40499-83-0 synthesis path| 40499-83-0 SDS| 40499-83-0 COA| 40499-83-0 purity| 40499-83-0 application| 40499-83-0 NMR| 40499-83-0 COA| 40499-83-0 structure
A200586 [104706-47-0]
(R)-3-Hydroxypyrrolidine hydrochloride
Similarity: 0.96
A309806 [122536-94-1]
(S)-3-Hydroxypyrrolidine hydrochloride
Similarity: 0.96
A200586 [104706-47-0]
(R)-3-Hydroxypyrrolidine hydrochloride
Similarity: 0.96
A309806 [122536-94-1]
(S)-3-Hydroxypyrrolidine hydrochloride
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P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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