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Chemical Structure| 40447-15-2 Chemical Structure| 40447-15-2

Structure of 40447-15-2

Chemical Structure| 40447-15-2

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Product Details of [ 40447-15-2 ]

CAS No. :40447-15-2
Formula : C7H15NO2
M.W : 145.20
SMILES Code : CC(NCCCCCO)=O

Safety of [ 40447-15-2 ]

Application In Synthesis of [ 40447-15-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 40447-15-2 ]

[ 40447-15-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 38222-83-2 ]
  • [ 2508-29-4 ]
  • [ 40447-15-2 ]
  • 5-acetamido-1-pentyl triflate [ No CAS ]
YieldReaction ConditionsOperation in experiment
With trifluoromethylsulfonic anhydride; acetic anhydride; triethylamine; In methanol; dichloromethane; A. 5-Acetamido-1-pentyl triflate (30). A solution of 5-amino-1-pentanol (0.650 g, 6.31 mmol) in methanol (15 mL) is cooled to 0° C. and treated with triethylamine (1.62 mL, 11.6 mmol) followed by acetic anhydride (0.891 mL, 9.45 mmol). The reaction mixture is stirred at room temperature overnight. Additional triethylamine (1.6 mL, 11.6 mmol) and acetic anhydride (0.9 mL, 9.5 mmol) is added at room temperature and the solution is stirred 16 h further. Concentration in vacuo and flash chromatography affords 5-acetamido-1-pentanol. To a solution of 5-acetamido-1-pentanol (22.2 mmol) in dry dichloromethane (50 mL) is added <strong>[38222-83-2]2,6-di-tert-butyl-4-methylpyridine</strong> (4.6 g, 22.2 mmol) and triflic anhydride (3.7 mL, 22.2 mmol) at 0° C. The reaction is stirred at room temperature for 20 min, poured into water, and extracted with dichloromethane. The combined extracts are dried over anhydrous sodium sulfate and concentrated in vacuo and to afford 5-acetamido-1-pentyl triflate (30) which is used without further purification.
 

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