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Chemical Structure| 40235-65-2 Chemical Structure| 40235-65-2
Chemical Structure| 40235-65-2

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Ethyl 2-(hydroxymethyl)thiazole-4-carboxylate

CAS No.: 40235-65-2

4.5 *For Research Use Only !

Cat. No.: A782912 Purity: 95%

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Product Details of [ 40235-65-2 ]

CAS No. :40235-65-2
Formula : C7H9NO3S
M.W : 187.22
SMILES Code : CCOC(=O)C1=CSC(CO)=N1
MDL No. :MFCD20924035

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Application In Synthesis [ 40235-65-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 40235-65-2 ]

[ 40235-65-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 40235-65-2 ]
  • [ 78502-71-3 ]
YieldReaction ConditionsOperation in experiment
With N-Bromosuccinimide;dibenzoyl peroxide; In 1,2-dichloro-ethane; at 70℃; for 85h; Preparation 23 Ethyl 2-bromomethylthiazole 4-carboxylate [0323] [CHEMMOL-00080] [0324] A mixture of ethyl-2-methylthiazole 4-carboxylate (500 mg, 2.9 mmol), N-bromosuccinimide (877 mg, 4.9 mmol), and benzoyl peroxide (5-10 mg) in 1,2-DCE (3 mL) was heated at 70 C. for 85 h. After cooling to room temperature, DCM (10 ml) was added and washed with water (3 times). The organic layer was dried over Na2SO4 and evaporated in vacuo. The residue was purified by preparative chromatography to yield the above-titled compound (58 mg). 1H NMR (CDCl3): 8.23 (1H, s), 4.77 (2H, s), 4.43 (2H, q), 1.42 (3H, t).
 

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