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Chemical Structure| 65412-03-5 Chemical Structure| 65412-03-5
Chemical Structure| 65412-03-5

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Product Details of 4-Aminoethyl-tetrahydropyrane

CAS No. :65412-03-5
Formula : C7H15NO
M.W : 129.20
SMILES Code : NCCC1CCOCC1
MDL No. :MFCD02179433
InChI Key :BZMADPOGYCRPAI-UHFFFAOYSA-N
Pubchem ID :2773198

Safety of 4-Aminoethyl-tetrahydropyrane

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 4-Aminoethyl-tetrahydropyrane

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 65412-03-5 ]

[ 65412-03-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 65412-03-5 ]
  • 5-(4-bromomethyl-2-methoxyphenoxy)pyrazine-2-carboxamide [ No CAS ]
  • [ 676500-67-7 ]
YieldReaction ConditionsOperation in experiment
68% In dichloromethane; at 40.0℃; for 4.0h; 5- (4-bromomethyl-2-methoxyphenoxy) pyrazine-2-carboxamide (starting from 5- (4-bromomethyl-2-methoxybenzeneOxy) pyrazine-2-carboxamide was added in the same manner as in Groups 1 to 5, respectively, and the amount of the added amount2), 5.3 g (41 mmol) of 2- (tetrahydropyran-4-yl) ethylamine, 187 ml of dichloromethane was added to a 250 ml three-necked flask, The reaction system was heated to reflux (40 C) and reacted under reflux for 4 hours. After the reaction time, the reaction was stopped and the pressure wasConcentrated by heating and concentrated to complete a solid which was stirred with 100 ml of water for 1 hour, filtered and dried to about 11G of a white solid which was added to 300 ml of ethyl acetate, washed with 100 ml of 2M aqueous sodium hydroxide solution, and the organic phaseWashed with 100 ml of X2 and the organic phase dried to give 10 g of a white solid (yield: 75.7%, purity: 98.5%). Table 2 showsEffect of the amount of 2- (tetrahydropyran-4-yl) ethylamine on the yield and purity of the product.(3) times purified Fupu Lan10 g of a white solid was placed in a 100 ml three-necked flask,Add 60 ml of isopropyl alcohol, start heating,At 65 under the basic full solution, continue to heat,And adding 0.7 g of activated carbon,Heating at 70-75 C for 30 minutes, followed by hot filtration,The filtrate gradually cooled to room temperature,And continue to stir in the ice bath for 1.5 hours, filter, dry,9.0 g of a white crystalline solid (yield: 68%, purity: 99.8%),The filtered mother liquor was concentrated and 0.3 g of solid (94.3% purity) was recovered.
 

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