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Chemical Structure| 393-11-3 Chemical Structure| 393-11-3
Chemical Structure| 393-11-3

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Product Details of 4-Nitro-3-(trifluoromethyl)aniline

CAS No. :393-11-3
Formula : C7H5F3N2O2
M.W : 206.12
SMILES Code : C1=C(N)C=CC(=C1C(F)(F)F)[N+]([O-])=O
MDL No. :MFCD00014717
InChI Key :UTKUVRNVYFTEHF-UHFFFAOYSA-N
Pubchem ID :94955

Safety of 4-Nitro-3-(trifluoromethyl)aniline

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 4-Nitro-3-(trifluoromethyl)aniline

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 393-11-3 ]

[ 393-11-3 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 42926-52-3 ]
  • [ 393-11-3 ]
  • 2-ethoxy-N-(4-nitro-3-trifluoromethyl-phenyl)-benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In dichloromethane; 2-ethoxy--benzoyl chloride was condensed with 5-Amino-2-nitrobenzotrifluoride in dichloromethane in presence of triethylamine as acid scavenger to yield 2-Ethoxy-N-(4-nitro-3-trifluromethyl-phenyl)-benzamide. The reaction mixture was then concentrated in vacuo and the residue was extracted into ethyl acetate. The ethyl acetate layer was washed with water and with cold aqueous hydrochloric acid, then dried over sodium sulphate and finally concentrated in vacuo. The residue obtained was chromatographed over silica gel to afford the desired product. 1H-NMR:delta6.95-8.10 (7H,aromatic), delta3.98(2H,t,OCH2), delta1.33(3H,t,Methyl)
  • 2
  • [ 628-36-4 ]
  • [ 393-11-3 ]
  • 4-(4-nitro-3-trifluoromethylphenyl)-1,2,4-triazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
PREPARATION 46 4-(4-Nitro-3-trifluoromethylphenyl)-1,2,4-triazole The following compound m.p. 100°, was prepared similarly to the previous Preparation using 4-nitro-3-trifluoromethylaniline and 1,2-<strong>[628-36-4]diformylhydrazine</strong> as the starting materials: STR126 Analysis percent: Found: C, 41.9; H, 2.0; N, 21.7; Calculated for C9 H5 N4 F3 O2: C, 41.6; H, 2.1; N, 22.2.
  • 3
  • [ 393-11-3 ]
  • [ 161622-05-5 ]
  • [ 691887-57-7 ]
YieldReaction ConditionsOperation in experiment
Example 65 (General Procedure (D)) 3-Fluoro-N-(4-Nitro-3-Trifluoromethyl-Phenyl)-5-Trifluoromethyl-Benzamide. The title compound was prepared from <strong>[161622-05-5]3-fluoro-5-trifluoromethyl-benzoic acid</strong> and 4-nitro-3-trifluoromethylanilin. 1H NMR (DMSO-d6): delta ppm 8.05 (d, 1 H) 8.16 (d, 1 H) 8.21 (s, 1 H) 8.32 (m, 2 H) 8.43 (d, J=1.88 Hz, 1 H) 11.18 (s, 1 H); HPLC-MS (Method A): m/z=397 (M+1); Rt=5.0 min.
  • 4
  • [ 67515-55-3 ]
  • [ 393-11-3 ]
  • 4-Fluoro-N-(4-Nitro-3-Trifluoromethyl-Phenyl)-3-Trifluoromethyl-Benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
Example 67 (General Procedure (D)) 4-Fluoro-N-(4-Nitro-3-Trifluoromethyl-Phenyl)-3-Trifluoromethyl-Benzamide. The title compound was prepared from <strong>[67515-55-3]4-fluoro-3-trifluoromethylbenzoic acid</strong> and 4-nitro-3-trifluoromethylanilin. 1H NMR (DMSO-d6): delta ppm 7.77 (m, 1 H) 8.29 (s, 1 H) 8.31 (d, J=2.26 Hz, 1 H) 8.39 (m, 3 H) 11.15 (m, 1 H); HPLC-MS (Method A): m/z=397 (M+1); Rt=4.9 min.
 

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