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Chemical Structure| 186407-74-9 Chemical Structure| 186407-74-9
Chemical Structure| 186407-74-9

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Product Details of 4-Bromo-1H-indazole

CAS No. :186407-74-9
Formula : C7H5BrN2
M.W : 197.03
SMILES Code : BrC1=C2C(=CC=C1)[NH]N=C2
MDL No. :MFCD05664001
InChI Key :KJIODOACRIRBPB-UHFFFAOYSA-N
Pubchem ID :22352548

Safety of 4-Bromo-1H-indazole

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H315-H319-H335
Precautionary Statements:P301+P310+P330-P302+P352-P305+P351+P338
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of 4-Bromo-1H-indazole

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 186407-74-9 ]

[ 186407-74-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 885069-14-7 ]
  • [ 186407-74-9 ]
  • [ 1112980-20-7 ]
YieldReaction ConditionsOperation in experiment
With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; water; at 95℃; Example 99; <n="73"/>N-(6-(1H-Indazol-4-yl)benzo[d]thiazol-2-yl)acetamide; 4-Bromo-1H-indazole (96.8 mg, 0.491 mmol), N-(6-(4,4,5,5-tetramethyl-l ,3,2-dioxaborolan-2- yl)benzo[d]thiazol-2-yl)acetamide (193.2 mg, 6.072 mmol), and tetrakis(triphenylphosphine)palladium(0) (51.5 mg, 44.6 mumol) were suspended in 1 ,4-dioxane (2.0 mL) and sodium carbonate (0.50 mL, 2M in water, 1.0 mmol) was added. The flask was fit with a reflux condensor and placed in a preheated oil bath (95 C) and stirred under nitrogen overnight. The mixture was then cooled to RT and filtered through a pad of Celite(diatomaceous earth). The filtrate was concentrated and purified on HPLC ( 10- 95% MeCN / water with 0.1% TFA over 40 minutes) to give N-(6-(1H-indazol-4-yl)benzo[d]thiazol-2- yl)acetamide. MS (ESI pos. ion) m/z: 309 (MH+). Calculated exact mass for C16H12N4OS: 308.
 

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