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Chemical Structure| 461-82-5 Chemical Structure| 461-82-5
Chemical Structure| 461-82-5

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Product Details of 4-(Trifluoromethoxy)aniline

CAS No. :461-82-5
Formula : C7H6F3NO
M.W : 177.12
SMILES Code : NC1=CC=C(OC(F)(F)F)C=C1
MDL No. :MFCD00041314
InChI Key :XUJFOSLZQITUOI-UHFFFAOYSA-N
Pubchem ID :600848

Safety of 4-(Trifluoromethoxy)aniline

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H227-H301+H311+H331-H315-H318-H373
Precautionary Statements:P210-P261-P280-P301+P310-P305+P351+P338
Class:8(6.1)
UN#:2922
Packing Group:

Application In Synthesis of 4-(Trifluoromethoxy)aniline

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 461-82-5 ]
  • Downstream synthetic route of [ 461-82-5 ]

[ 461-82-5 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 461-82-5 ]
  • [ 175203-85-7 ]
References: [1] Bioorganic and Medicinal Chemistry, 1998, vol. 6, # 4, p. 389 - 399.
  • 2
  • [ 870072-76-7 ]
  • [ 461-82-5 ]
  • [ 870544-59-5 ]
YieldReaction ConditionsOperation in experiment
95% at 80℃; for 1.5 h; Inert atmosphere General procedure: The substituted aniline (1 eq, 0.2mmol) was added to a solution of isocyanate (1 eq, 0.2mmol) in toluene (1mL) under argon. The resulting mixture was stirred at 80°C for 1.5h. The solvent was removed by rotary evaporation, and the crude product was purified by flash chromatography to give the diarylurea as colorless solid.
References: [1] European Journal of Medicinal Chemistry, 2019, p. 142 - 159.
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 4, p. 1704 - 1714.
 

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