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Chemical Structure| 396091-35-3 Chemical Structure| 396091-35-3

Structure of 396091-35-3

Chemical Structure| 396091-35-3

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Product Details of [ 396091-35-3 ]

CAS No. :396091-35-3
Formula : C21H29NOSi
M.W : 339.55
SMILES Code : CC([Si](OC1CCNCC1)(C2=CC=CC=C2)C3=CC=CC=C3)(C)C

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Application In Synthesis of [ 396091-35-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 396091-35-3 ]

[ 396091-35-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 396091-35-3 ]
  • [ 5932-32-1 ]
  • (4-((tert-butyldiphenylsilyl)oxy)piperidin-1-yl)(1,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)methanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
To a mixture of <strong>[5932-32-1]1,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylic acid</strong> (A-3) (3.50 g, 23.00 mmol) in DMF (92 ml) at ambient temperature were added HATU (10.50 g, 27.6 mmol) and TEA (3.85 ml, 27.6 mmol). The mixture was stirred for 10 min before adding a solution of 4-((tert-butyldiphenylsilyl)oxy)piperidine (A-2) (29.9 ml, 29.9 mmol) in DCM. The mixture was stirred for 3 h before quenching with water (100 mL) and taking up in EtOAc (250 mL). The mixture was washed with a sat. solution of NaHCO3(200 mL x 2), water (200 mL), and brine (200 mL). The organic layer was dried over Na2SO4and concentrated. The residue was purified by column chromatography on silica (2-60% 3:1 EtOAc:EtOH/hexane) to afford the title compound. MS: 474.4 (M+1).
 

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