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Chemical Structure| 39224-61-8 Chemical Structure| 39224-61-8

Structure of 39224-61-8

Chemical Structure| 39224-61-8

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Tang, Jian-Hong ; Luo, Minrui ; Tsao, Wilhelmina ; Waters, Emily Alexandria ; Parigi, Giacomo ; Luchinat, Claudio , et al.

Abstract: Glycoconjugates forming from the conjugation of carbohydrates to other biomolecules, such as proteins, lipids, or other carbohydrates, are essential components of mammalian cells and are involved in numerous biological processes. Due to the capability of sugars to form multiple hydrogen bonds, many synthetic glycoconjugates are desirable biocompatible platforms for imaging, diagnostics, drugs, and supramolecular self-assemblies. Herein, we present a multimeric galactose functionalized paramagnetic gadolinium (Gd(III)) chelate that displays spontaneous dynamic aggregation in aqueous conditions. The dynamic aggregation of the Gd(III) complex was shown by the concentration-dependent magnetic resonance (MR) relaxation measurements, nuclear magnetic resonance dispersion (NMRD) analysis, and dynamic light scattering (DLS). Notably, these data showed a nonlinear relationship between magnetic resonance relaxation rate and concentrations (0.03−1.35 mM), and a large DLS hydrodynamic radius was observed in the high-concentration solutions. MR phantom images were acquired to visualize real-time dynamic aggregation behaviors in aqueous solutions. The in situ visualization of the dynamic self-assembling process of multivalent glycoconjugates has rarely been reported.

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Product Details of [ 39224-61-8 ]

CAS No. :39224-61-8
Formula : C7H7NO4
M.W : 169.13
SMILES Code : OC1=CC=C([N+]([O-])=O)C=C1CO
MDL No. :MFCD01321361
Boiling Point : No data available
InChI Key :JEIYIXDNZKATLC-UHFFFAOYSA-N
Pubchem ID :2763823

Safety of [ 39224-61-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H317-H319
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 39224-61-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 39224-61-8 ]
 

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