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Chemical Structure| 392-95-0 Chemical Structure| 392-95-0

Structure of 392-95-0

Chemical Structure| 392-95-0

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Product Details of [ 392-95-0 ]

CAS No. :392-95-0
Formula : C7H2ClF3N2O4
M.W : 270.55
SMILES Code : FC(C1=C(Cl)C([N+]([O-])=O)=CC([N+]([O-])=O)=C1)(F)F
MDL No. :MFCD00007076
InChI Key :RLXKADBMLQPLDV-UHFFFAOYSA-N
Pubchem ID :67851

Safety of [ 392-95-0 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H315-H318-H331
Precautionary Statements:P261-P264-P271-P280-P302+P352+P332+P313+P362+P364-P304+P340+P312-P305+P351+P338+P310
Class:8(6.1)
UN#:2923
Packing Group:

Application In Synthesis of [ 392-95-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 392-95-0 ]

[ 392-95-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 4018-65-9 ]
  • [ 392-95-0 ]
  • 1-fluoromethyl-3-nitro-9-chlorodibenzo-p-dioxin [ No CAS ]
  • 1-fluoromethyl-3-nitro-6-chlorodibenzo-p-dioxin [ No CAS ]
  • 2
  • [ 392-95-0 ]
  • [ 214360-70-0 ]
  • [ 1206794-39-9 ]
YieldReaction ConditionsOperation in experiment
38% With sodium carbonate;tetrakis(triphenylphosphine) palladium(0); In water; toluene; for 67h;Inert atmosphere; Reflux; Example 1 : 3-[2.4-dinitro-6-(trifluoromethyl)phenvnthiophene; A solution of 2-chloro-3,5-dinitrobenzotrifluoride (214mg, 0.79mmol) and 3- (4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)thiophene (178mg, 0.85mmol) in toluene (3mL) was treated with 2M aqueous sodium carbonate (0.445mL, 0.89mmol). The mixture was flushed with nitrogen and tetrakis(triphenylphosphine)palladium(0) (44mg, 0.04mmol) was added. The mixture was then refluxed under nitrogen for 67 hours. The reaction was allowed to cool and saturated aqueous sodium carbonate (8ml_) was added. The mixture was extracted with dichloromethane (3 x 3OmL) and the combined organic extract was dried over MgSO4 before being evaporated to dryness. The crude product was chromatographed over silica gel. Elution with ethyl acetate/hexanes (1 :9) gave the title compound as a pale yellow solid (96mg, 38%), m.p. 104-50C. 1HNMR (300 MHz, CDCI3): 8.81 , 8.73 (ABq, 2H, J=2.2), 7.46 (dd, 1H, J=5.0, 3.0), 7.35 (br s, 1 H), 7.09 (d, 1 H, J=5.0).
 

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