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Chemical Structure| 39172-32-2 Chemical Structure| 39172-32-2

Structure of 39172-32-2

Chemical Structure| 39172-32-2

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Product Details of [ 39172-32-2 ]

CAS No. :39172-32-2
Formula : C10H11BrO2
M.W : 243.10
SMILES Code : CC1(C2=CC=CC(Br)=C2)OCCO1

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Application In Synthesis of [ 39172-32-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 39172-32-2 ]

[ 39172-32-2 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 39172-32-2 ]
  • [ 23719-80-4 ]
  • [ 408359-52-4 ]
YieldReaction ConditionsOperation in experiment
72%
Stage #1: for 5 h; Heating / reflux
Stage #2: for 5 h; Heating / reflux
Stage #3: With hydrogenchloride In tetrahydrofuran; water at 20℃; for 1.5 h;
Pd(PPh3)4 (640 mg) was added followed by the addition of 2-(3-bromo-phenyl)-2-methyl-[1,3]dioxolane (5.05 g, 20.87 mmol) in 80 mL of tetrahydrofuran.
The mixture was refluxed for 5 hours and another portion of cyclopropyl magnesium bromide (made from 2 g of bromocyclopropane and 0.4 g magnesium turnings in 15 mL of tetrahydrofuran) was added and the mixture was again refluxed for 5 hours.
The solution was poured into 1 N HCl (150 mL) and stirred at room temperature for 1.5 hours and the mixture was extracted with diethyl ether.
The extract was dried (Na2SO4) and concentrated.
The residue was chromatographed (30percent ethyl acetate/hexanes) to give 3-cyclopropyl-acetylphenone as an oil, 4.05 g, 72 percent.
References: [1] Patent: US2004/6058, 2004, A1, . Location in patent: Page/Page column 29.
 

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