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Chemical Structure| 389621-83-4 Chemical Structure| 389621-83-4

Structure of 389621-83-4

Chemical Structure| 389621-83-4

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Product Details of [ 389621-83-4 ]

CAS No. :389621-83-4
Formula : C12H16BNO3
M.W : 233.07
SMILES Code : OB(O)C1=CC=C(C=C1)C(=O)N1CCCCC1
MDL No. :MFCD03411951
InChI Key :PUXUKRSBJVVKMD-UHFFFAOYSA-N
Pubchem ID :2773567

Safety of [ 389621-83-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P233-P260-P261-P264-P270-P271-P280-P301+P312-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501

Application In Synthesis of [ 389621-83-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 389621-83-4 ]

[ 389621-83-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 389621-83-4 ]
  • [ 1010120-55-4 ]
  • C18H19N5O [ No CAS ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate;(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; An appropriate Ar substituted boronic acid derivative (2eq.) is added to a solution of 2-amino-8-bromo-triazolopyridine (Commercially available, BiofocusDPI) in dioxan/water (5:1). K2CO3 (2 eq.) and PdC^dppf (5%) are added to the mixture. The resulting mixture is heated in a microwave oven at 1400C for 15-45 min or heated in an oil bath at 900C for 4 to 16 h until the reaction goes to completion (monitored by LCMS). Water is added and the mixture is extracted with ethyl acetate. The organic layers are combined, dried over anhyd. MgSO4 and evaporated in vacuo to yield the crude product. The crude product is then purified by flash chromatography to give the corresponding 2-amino-5-Ar-triazolopyridine derivative (2).
 

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