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Chemical Structure| 384821-19-6 Chemical Structure| 384821-19-6

Structure of 384821-19-6

Chemical Structure| 384821-19-6

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Product Details of [ 384821-19-6 ]

CAS No. :384821-19-6
Formula : C6H11N3
M.W : 125.17
SMILES Code : CNCC1=CN=CN1C
MDL No. :MFCD07772801

Safety of [ 384821-19-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 384821-19-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 384821-19-6 ]

[ 384821-19-6 ] Synthesis Path-Downstream   1~15

  • 1
  • [ 596-43-0 ]
  • [ 384821-19-6 ]
  • N-trityl-N-methyl-5-aminomethyl-1-methyl-1H-imidazole [ No CAS ]
  • 2
  • [ 24424-99-5 ]
  • [ 384821-19-6 ]
  • N-(tert-butoxycarbonyl)-N-methyl-5-aminomethyl-1-methyl-1H-imidazole [ No CAS ]
  • 3
  • [ 106-95-6 ]
  • [ 384821-19-6 ]
  • [ 384821-24-3 ]
  • 4
  • Methyl-[1-(3-methyl-3H-imidazol-4-yl)-meth-(E)-ylidene]-amine [ No CAS ]
  • [ 384821-19-6 ]
  • 5
  • [ 39021-62-0 ]
  • [ 384821-19-6 ]
  • 6
  • [ 38993-84-9 ]
  • [ 384821-19-6 ]
  • 7
  • [ 143122-18-3 ]
  • [ 384821-19-6 ]
  • 8
  • [ 384821-19-6 ]
  • bis(N-allyl-N-methyl-5-aminomethyl-1-methyl-1H-2-imidazolyl)ketone [ No CAS ]
  • 9
  • [ 384821-19-6 ]
  • [ 384821-27-6 ]
  • 10
  • [ 384821-19-6 ]
  • [ 384821-31-2 ]
  • 11
  • [ 384821-19-6 ]
  • [ 384821-30-1 ]
  • 12
  • [ 384821-19-6 ]
  • [ 384821-29-8 ]
  • 13
  • [ 384821-19-6 ]
  • [ 384821-26-5 ]
  • 14
  • [ 384821-19-6 ]
  • [ 384821-25-4 ]
  • 15
  • [ 1141504-93-9 ]
  • [ 384821-19-6 ]
  • [ 1141505-19-2 ]
YieldReaction ConditionsOperation in experiment
66% With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20.0℃; for 18.0h; To a mixture of 3-{3-[2,2,2-Trifluoro-ethyl)-ureido]-imidazo[1 ,2-a]pyridine-7- carboxylic acid (600 mg, 1.45 mmol), HBTU (823 mg, 2.17 mmol), triethylamine (402 mul_, 2.9 mmol) in a 10/1 mixture of THF/DMF (15 ml_) was added, under an atmosphere of N2, (1-lambda/-methyl-imidazol-5-yl)methylamine (322 mg, 2.89 mmol). The reaction mixture was stirred at room temperature for 18 hours then quenched with water. The aqueous layer was extracted with AcOEt. The organic layer was allowed to stand overnight. The precipitate was filtered off to afford 3-{3-[2,2,2-Trifluoro-ethyl)-ureido]-imidazo[1 ,2-a]pyridine-7-[5-(1-lambda/- methyl-imidazole)]-methylamide (454 mg, 66%).1H NMR (500 MHz, DMSO-d6): 9.15 (br. s., 1 H), 9.07 (br. s., 1 H), 8.61 (d, J = 7.25 Hz, 1 H), 8.25 (s, 1 H), 7.89 (s, 1 H), 7.77 (s, 1 H), 7.56 (s, 1 H), 7.39 - 7.52 (m, 3 H), 7.26 (d, J = 7.25 Hz, 1 H), 7.11 (br. s., 1 H), 6.87 (s, 1 H), 4.51 (s, 2 H), 3.93 (q, J = 9.77 Hz, 2 H), 3.64 (s, 3 H). MS: [M+H] +: 472.2 Melting point > 2600C
 

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