There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 3840-30-0 | MDL No. : | MFCD00040716 |
Formula : | C10H13ClO3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | XXRUQNNAKXZSOS-UHFFFAOYSA-N |
M.W : | 216.66 | Pubchem ID : | 77448 |
Synonyms : |
|
Signal Word: | Danger | Class: | 8 |
Precautionary Statements: | P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P321-P363-P405-P501 | UN#: | 3261 |
Hazard Statements: | H314 | Packing Group: | Ⅱ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
78% | In dichloromethane; water Heating; | |
Stage #1: 2-hydroxy-2,4,6-cycloheptatrien-1-one With tetra(n-butyl)ammonium hydroxide In water at 20℃; for 1h; Stage #2: 5-(chloromethyl)-1,2,3-trimethoxybenzene In dichloromethane for 24h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: LiAlH4; diethyl ether 2: aqueous HCl | ||
Multi-step reaction with 2 steps 1: LiAlH4, AlBr3 2: aq. HCl | ||
Multi-step reaction with 2 steps 1: LiAlH4 / diethyl ether 2: HCl / benzene / 0 °C |
Multi-step reaction with 2 steps 1: LiAlH4 / diethyl ether / Heating 2: SOCl2 / benzene | ||
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran 2: thionyl chloride / dichloromethane | ||
Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / Inert atmosphere 2: thionyl chloride; pyridine / dichloromethane / 1.5 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium carbonate; In water; acetonitrile; | REFERENCE EXAMPLE 19 A mixture of methyl 4-(tert-butoxycarbonyl)piperazine-2-carboxylate (3.5 g) obtained in Reference Example 16, 3,4,5-trimethoxybenzyl chloride (4.6 g), potassium carbonate (6.0 g) and acetonitrile (80 ml) is refluxed by heating for 10 hours while stirring. The reaction mixture is concentrated under reduced pressure. The concentrate is added to water and extracted with ethyl acetate. The organic layer is washed with water and dried, then the solvent is distilled off under reduced pressure. The residue is purified by means of a silica gel column chromatography (hexane:ethyl acetate =3:2) to afford methyl 4-tert-butoxycarbonyl-1-(3,4,5-trimethoxy-benzyl)piperazine-2-carboxylate as a colorless oily product (5.2 g). | |
With potassium carbonate; In water; acetonitrile; | Reference Example 19 A mixture of methyl 4-(tert-butoxycarbonyl)piperazine-2-carboxylate (3.5 g) obtained in Reference Example 16, 3,4,5-trimethoxybenzyl chloride (4.6 g), potassium carbonate (6.0 g) and acetonitrile (80 ml) is refluxed by heating for 10 hours while stirring. The reaction mixture is concentrated under reduced pressure. The concentrate is added to water and extracted with ethyl acetate. The organic layer is washed with water and dried, then the solvent is distilled off under reduced pressure. The residue is purified by means of a silica gel column chromatography (hexane:ethyl acetate = 3:2) to afford methyl 4-tert-butoxycarbonyl-1-(3,4,5-trimethoxybenzyl)piperazine-2-carboxylate as a colorless oily product (5.2 g). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
4 EXAMPLE 4 EXAMPLE 4 8.3 g of 3,4,5-trimethoxybenzyl chloride and 3.8 g of N-(2-ethylphenyl)-piperazine and 3.5 g of K2 CO3 are reacted and processed according to example 2. 6.5 g of N-(3,4,5-trimethoxy-benzyl)-N'-(2-ethylphenyl)-piperazine dihydrochloride is obtained. Mp.: 179° C. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
19 EXAMPLE 19 EXAMPLE 19 11.0 g of 3,4,5-trimethoxybenzyl chloride, 9.51 g of N-(2,6-dimethylphenyl)-piperazine and 7.00 g of K2 CO3 are reacted and processed according to example 14. 8.6 of N-(3,4,5-trimethoxy-benzyl)-N'-(2,6-dimethylphenyl)-piperazine hydrochloride is obtained. Mp.: 218° C. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
16% | With triethylamine; In ethanol; at 120℃; for 1h;Microwave; | A microwave tube (1OmL) was charged with 6-methoxytetrahydroisoquinoline hydrochloride (300mg, 1.5 mmol), 3,4,5-trimethoxybenzylchloride (325 mg, 1.5 mmol), triethylamine (0.5 mL, 3.6 mmol) dissolved in ethanol (5 mL) and sealed. The Vial was heated to 120 0C with 150W for 60 minutes. After cooling to room temperature the solution was dissolved in ethyl acetate and washed with water (2 x 10 mL), brine (10 mL)5 dried over MgSO4 and evaporated to dryness in vacuo. Purification by flash column chromatography on a flashmaster system (1:0-1:1 petrol 40-60:ethylacetate) afforded the desired compound in 16 % yield (81 mg) and >97 % purity as a soft solid, m.p.102-103 C; 1H NMR (270 MHz5 CDCl3) £2.69 (2H5 d, J= 7.8), 2.87 (2H51, J= 7.8), 3.58 (2H, s), 3.59 (2H, s), 3.77 (3H, s), 3.84 (3H, s), 3.85 (6H, s), 6.62-6.71 (4H, m), 6.92 (IH5 d, J= 8.2); HRMS (ESI+) calcd. for C20H26NO4 (M+-I-H) 344.1856, found 344.1842; LC/MS (ES+) tt = 2.165 min, m/z 344.4 (M++H); HPLC ttau = 2.47 min (>97%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
62% | With triethylamine In ethanol at 130℃; for 1h; Microwave irradiation; | |
62% | With triethylamine In ethanol at 130℃; for 1h; Microwave; | 2 A mixture of 6,7-dimethoxytetrahydroisoquinoline hydrochloride (0.23g, 1 mmol), 3,4,5- trimethoxybenzyl chloride (0.26g, 1.2mmol) in TEA (0.5 mL) and ethanol (2.5 mL) was subjected to microwave heating to 130°C for Ih. The mixture was poured into water, the organics extracted with ethyl acetate and the organic layer washed with water, brine, dried (MgSO4), filtered and concentrated under reduced pressure. The resultant crude solid was purified by flash chromatography (hexane/ethyl acetate 6:1 to 1:1) to give a white solid which was stirred in diethyl ether, filtered and dried under vacuum to afford a white powder (230mg, 62%), mp= 118-119°C, Rf. 0.43 (EtOAc), 1H NMR (270 MHz, CDCl3) δ 2.70 (2H, t, J= 5.6Hz, CH2), 2.81 (2H, t, J= 5.6Hz, CH2), 3.55 (2H, s, CH2), 3.59 (2H, s, CH2), 3.81 (3H, s, CH3O), 3.83 (3H, s, CH3O), 3.84 (3H, s, CH3O), 3.85 (6H, s, CH3O), 6.50 (IH, s, ArH), 6.60 (IH, s, ArH), 6.62 (2H, s, ArH); 13C NMR (67.5 MHz, CDCl3) δ 28.8 (CH2), 50.7 (CH2), 55.9 (CH2), 56.0 (2xCH3O), 56.2 (2xCH3O), 61.0 (CH3O), 63.1 (CH2), 105.6 (2xCH(Ar)), 109.5 (CH(Ar)), 111.4 (CH(Ar)), 126.3 (C(Ar)), 126.8 (C(Ar)), 134.5 (C(Ar)), 136.7 (C(Ar)), 147.3 (C(Ar)), 147.6 (C(Ar)), 153.2 (2xCH(Ar)). LC/MS (ES+) tr =0.93 min m/z 374.27 (M+H)+; MeOH/H2O 95/5; HPLC tr =3.62 min (99.2%). (CH3CN/H2O 70:30) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
82% | With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20℃; for 4h; | 2-MERCAPTO-1-METHYLIMIDAZOLE (228.5 mg, 2 mmol), N, N-DIISOPROPYLETHYLAMINE (0.45 ML, 1.25 eq. ) and 3,4, 5-trimethoxybenzyl chloride (455 mg, 1.05 eq. ) were added to 2 ml dry DIMETHYLFORMAMIDE and the mixture was stirred at room temperature for 4 hours. The solvent was removed under reduced pressure and the residue was purified by MPFC (hexane/dichloromethane gradient) to give the desired 1-METHYL-2- (3, 4,5-trimethoxybenzylthio)-imidazole as a waxy, white solid in 82% yield, which was identified as compound 1. The structure of this compound was as follows: |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
56% | With tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide In dichloromethane; water at 25℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
57% | With tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide In dichloromethane; water at 25℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
45% | With tetra(n-butyl)ammonium hydrogensulfate; potassium hydroxide In dichloromethane; water at 25℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
General procedure: A solution of appropriate phenol 4a-ed (1.0 mmol) in a small amount of DMSO (2 mL) was added to a solution of KOH (174 mg,3.11 mmol) in DMSO (2.5 mL). The mixture was stirred at rt for 15 min, and then a solution of the appropriate arylmethylchloride (1.0 mmol) in DMSO (2 mL) was added dropwise to the solution of 4. The suspension was stirred at room temperature for 12 h, and then it was diluted with AcOEt and washed with water and brine. The organic layer was dried and concentrated. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
71% | In toluene for 48h; Reflux; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water at 80℃; for 24h; Inert atmosphere; Schlenk technique; | 6 2.2.1 General procedure for the preparation of ortho-formyl diarylmethanes 3 via the Suzuki-Miyaura reaction General procedure: A Schlenk flask (25mL) containing a biphasic mixture of oxygen free THF (10mL) and aqueous 2M solution of K2CO3 (4mL) was immersed in the oil bath. Then, ortho-formyl aromatic boronic acid 1 (2.40mmol), benzylic type halide 2 (2.20mmol) and Pd(PPh3)4 (0.06mmol) were added and the temperature of the oil bath was maintained at 80°C. The mixture was vigorously stirred at this temperature for 24h under argon atmosphere.Then, it was allowed to cool down, washed with H2O (8mL) and extracted with ethyl acetate (3x10mL). The organic layer was dried over anhydrous MgSO4. The solvent was removed in vacuum and crude product was purified by column chromatography over silica gel using a mixture of petroleum ether/acetone (20/1) as eluent. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
93% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water at 80℃; for 24h; Inert atmosphere; Schlenk technique; | 7 2.2.1 General procedure for the preparation of ortho-formyl diarylmethanes 3 via the Suzuki-Miyaura reaction General procedure: A Schlenk flask (25mL) containing a biphasic mixture of oxygen free THF (10mL) and aqueous 2M solution of K2CO3 (4mL) was immersed in the oil bath. Then, ortho-formyl aromatic boronic acid 1 (2.40mmol), benzylic type halide 2 (2.20mmol) and Pd(PPh3)4 (0.06mmol) were added and the temperature of the oil bath was maintained at 80°C. The mixture was vigorously stirred at this temperature for 24h under argon atmosphere.Then, it was allowed to cool down, washed with H2O (8mL) and extracted with ethyl acetate (3x10mL). The organic layer was dried over anhydrous MgSO4. The solvent was removed in vacuum and crude product was purified by column chromatography over silica gel using a mixture of petroleum ether/acetone (20/1) as eluent. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
79% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water at 80℃; for 24h; Inert atmosphere; Schlenk technique; | 9 2.2.1 General procedure for the preparation of ortho-formyl diarylmethanes 3 via the Suzuki-Miyaura reaction General procedure: A Schlenk flask (25mL) containing a biphasic mixture of oxygen free THF (10mL) and aqueous 2M solution of K2CO3 (4mL) was immersed in the oil bath. Then, ortho-formyl aromatic boronic acid 1 (2.40mmol), benzylic type halide 2 (2.20mmol) and Pd(PPh3)4 (0.06mmol) were added and the temperature of the oil bath was maintained at 80°C. The mixture was vigorously stirred at this temperature for 24h under argon atmosphere.Then, it was allowed to cool down, washed with H2O (8mL) and extracted with ethyl acetate (3x10mL). The organic layer was dried over anhydrous MgSO4. The solvent was removed in vacuum and crude product was purified by column chromatography over silica gel using a mixture of petroleum ether/acetone (20/1) as eluent. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
52% | With naphthalene; lithium In tetrahydrofuran at 0 - 20℃; Inert atmosphere; | 1 4.1.1 General method for synthesis of compounds 1a-f [19] General procedure: Under nitrogen, a mixture of naphthalene (3.75 eq) and lithium (3.75 eq) in anhydrous THF was stirred at room temperature for 2h. Then, a solution of beta-cyclocitral (1.1 eq) and the substituted benzyl chloride (1 eq) was added dropwise via syringe at 0°C. The reaction mixture was stirred at room temperature for 2h, then diluted with diethyl ether and treated with saturated NH4Cl. The organic phase was separated and the aqueous phase extracted with ethyl acetate. The combined organic layers were washed with brine, dried over Na2SO4 and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (4-10% ethyl acetate in petroleum ether). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 24 h / 80 °C / Inert atmosphere; Schlenk technique 2: dichloromethane / 24 h / 25 °C / Inert atmosphere; Schlenk technique |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
93% | In N,N-dimethyl-formamide at 80℃; for 24h; Inert atmosphere; Schlenk technique; | |
93% | In N,N-dimethyl-formamide at 80℃; for 24h; Inert atmosphere; Schlenk technique; | General procedure for the preparation of benzimidazolium salts General procedure: The benzimidazolium salts 2a-2j were prepared byreacting N-(isobutyl)-benzimidazole (1 mmol) (1) with various alkyl chloride (1.1 mmol) in dimethylformamide(DMF; 5 mL) at 80 °C and the resulting mixture was stirredfor 24 h. Diethyl ether (15 mL) was added to obtain a whitecrystalline solid, which was subsequently filtered off. Thesolid was washed with diethyl ether (3 × 10 mL), driedunder vacuum, and the crude product was recrystallizedfrom dichloromethane/diethyl ether (1:3 ratio). |
93% | In N,N-dimethyl-formamide at 80℃; for 24h; Inert atmosphere; Schlenk technique; | 2.2. General procedure for the preparation of benzimidazolium salts 2a-h General procedure: For the preparation of the benzimidazolium salts (2a-h), N-(isobutyl)-benzimidazole (1) (1.0 mmol) was dissolved in dried dimethylformamide(3 mL) and alkyl chloride (1.1 mmol) was slowlyadded. The reaction mixture was stirred at 80 °C for 24 h under argon.After completion of the reaction, all dimethylformamide was removedby vacuum, and diethyl ether (15 mL) was added to obtain a whitecrystalline solid that was then filtered off. The solid was washed withdiethyl ether (3x10 mL) and dried under vacuum. The crude productwas recrystallized from dichloromethane/diethyl ether. |
93% | In N,N-dimethyl-formamide at 80℃; for 24h; Inert atmosphere; Schlenk technique; | 2.2. General procedure for the preparation of benzimidazolium salts 2a-f General procedure: The benzimidazolium salts 2a-f were prepared by reacting 1-isobutyl-benzimidazole(1 mmol) (1) with various alkyl chloride (1.1 mmol) in dimethylformamide (DMF; 5 mL)at 80 C and the resulting mixture was stirred for 24 h. Diethyl ether (15 mL) wasadded to obtain a white crystalline solid, which was subsequently filtered off. The solidwas washed with diethyl ether (310 mL), dried under vacuum, and the crude productwas recrystallized from dichloromethane/diethyl ether (1:3 ratio).2.2.1 1-(Isobutyl)-3-(3,4,5-trimethoxylbenzyl)benzimidazolium chloride (2a)ield 93%, Mp: 136.2 C, IR mCN/cm1: 1437. 1H-NMR (400 MHz, CDCl3), d(ppm): 1.05 (d,6H, CH3(a,b)), 2.43 (Hep, 1H, H2’), 3.87 (s, 6H, CH3(c,e)), 3.80 (s, 3H, CH3(d)), 4.42 (d, 2H,H1’), 5.84 (s, 2H, H1’’), 6.90 (s, 2H, H3”,7”), 7.58-7.76 (m, 4H, H4, 5, 6, 7), 12.04 (s, 1H, H2).13C NMR (CDCl3, 100 MHz), d(ppm): 19.8 (Ca,b), 28.8 (C2’), 51.5 (C1”), 54.4 (C1‘), 56.6 (Cc,e),60.8 (Cd), 106.0 (C3”;7”), 113.1 (C4), 113.7 (C7), 127.0 (C5), 127.1 (C6), 128.5 (C2”), 131.1(C8), 131.67 (C9), 138.5 (C5”), 144.0 (C2), 153.8 (C4”,6”). Elemental analysis % forC21H27ClN2O3: calcd. C, 64.52; H, 6.96; N, 7.17. found C, 64.30; H, 6.90; N, 7.20. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 24 h / 80 °C / Inert atmosphere; Schlenk technique 2: potassium carbonate / 16 h / 80 °C / Inert atmosphere; Schlenk technique |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
97% | With thionyl chloride In benzene at 0 - 20℃; for 1.66667h; | Benzyl Chlorides; General Procedure General procedure: A solution of thionyl chloride (20.2 mmol) in benzene (2.25 mL) wasadded dropwise to a stirred and cooled (0-5 °C, ice bath) solution ofthe corresponding benzyl alcohol (10.1 mmol) in benzene (7 mL) over10 min. The reaction mixture was then warmed to room temperatureand stirred for 1.5 h. After completion of the reaction (TLC monitoring),benzene was evaporated in vacuo. Ethyl acetate was added (20mL) and the solution was washed with water. The organic layer wasseparated, dried over MgSO4, filtered and the solvent evaporated invacuo to afford the corresponding benzyl chloride. CAUTION We recommendthe use of protective equipment such as gloves due to theirritating and allergic properties of benzyl chlorides, especially thosecarrying multiple donor groups |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | In N,N-dimethyl-formamide at 80℃; for 24h; Inert atmosphere; Green chemistry; | 2.2. Synthesis of 1-(isobutyl)-3-(3.4.5-trimethoxylbenzyl) benzimidazolium chloride (2) For the preparation of the benzimidazolium salts N -(isoButyl)- benzimidazole (1.0 mmol) 1 was dissolved in dried dimethylfor- mamide (3 mL) and the 2-(chloromethyl) naphthalene (1.1 mmol) was slowly added. The reaction mixture was stirred at 80 °C for24 h under argon. After completion of the reaction, all dimethyl- formamide was removed by vacuum, and diethyl ether (15 mL) was added to obtain a white crystalline solid, which was filtered off. The solid was washed with diethyl ether (3 ×10 mL) and dried under vacuum. The crude product was recrystallized from a mixture of dichloromethane/diethyl ether to afford the entitled compound as a 1-(isobutyl) -3-(3.4.5-trimethoxylbenzyl) benzimi- dazolium chloride (2) (white solid, Yield = 92%) (see Scheme 1 )”. Yield 92%, Mp: 198.2 °C, IR CN/cm -1 : 1438. 1 HNMR (400 MHz, CDCl 3 ), (ppm): 1.03 (d, 6H, CH 3 (a,b)), 2.438 (Hep, 1H, H 2’ ), 2.43 (d, 6H, CH 3 (c,d)), 3.87 (s, 6H, CH 3 (c,e)), 3.81 (s, 3H, CH 3 (f)), 3.86 (s, 6H, CH 3 (e,g)), 4.35 (d, 2H, H 1’ ), 5.76 (s, 2H, H1’’), 6.88 (s, 2H, H 3”,7 ), 7.40 (s, 1H, H 4 ), 7.47 (s, 1H, H 7 ), 11.85 (s, 1H, H 2 ). 13 C NMR (CDCl 3 , 100 MHz), (ppm): 19.7 (Cc,d), 20.7 (Ca), 20.7 (Cb), 28.7 (C 2’ ), 51.2 (C 1”), 54.2 (C 1‘ ), 56.6 (Ce;g), 60.8 (Cf), 105.8 (C 3”;7 ), 112.8 (C 4 ), 113.3 (C 7 ), 128.8 (C 2”), 129.6 (C 8 ), 130.1 (C 9 ), 138.4 (C 5”), 137.2 (C 5;6 ), 138.4 (C 5”), 142.7 (C 2 ), 153.5 (C 4”,6 ). |
Tags: 3840-30-0 synthesis path| 3840-30-0 SDS| 3840-30-0 COA| 3840-30-0 purity| 3840-30-0 application| 3840-30-0 NMR| 3840-30-0 COA| 3840-30-0 structure
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :