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Chemical Structure| 379261-85-5 Chemical Structure| 379261-85-5

Structure of 379261-85-5

Chemical Structure| 379261-85-5

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Product Details of [ 379261-85-5 ]

CAS No. :379261-85-5
Formula : C10H11NO5
M.W : 225.20
SMILES Code : O=C(O)C1=CC=C([N+]([O-])=O)C(OC(C)C)=C1
MDL No. :MFCD14583078

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Application In Synthesis of [ 379261-85-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 379261-85-5 ]

[ 379261-85-5 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 379261-85-5 ]
  • [ 681465-85-0 ]
  • [ 1006030-83-6 ]
  • [ 1318208-92-2 ]
YieldReaction ConditionsOperation in experiment
5% General procedure: The aryl carboxylic acid monomer (6 mmol, comp. 4-6), Mukaiyama reagent (6 mmol) and Et3N (12 mmol) were dissolved in an anhydrous dichloromethane (100 mL). The solution was refluxed for 15 min. under N2. Then a solution of the corresponding arylamine (5 mmol, comp. 7-9) in an anhydrous dichloromethane (20 mL) was added to the reaction mixture and resulting solution was refluxed for 2 days. The solvent was evaporated under vacuum and the residue was subjected to the column of silica gel using the mixture of hexanes/ dichloromethane (2:3) as an eluent to give amide coupling products in moderate to good yields. Note: for the synthesis of 18, 2.5 eq. of corresponding aryl amine over 2-methoxyisophthalic acid was used.
 

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