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Chemical Structure| 3764-36-1 Chemical Structure| 3764-36-1

Structure of 3764-36-1

Chemical Structure| 3764-36-1

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Product Details of [ 3764-36-1 ]

CAS No. :3764-36-1
Formula : C8H6F3NO2
M.W : 205.13
SMILES Code : FC(F)(F)CC1=CC=C([N+]([O-])=O)C=C1
MDL No. :MFCD14525531

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Application In Synthesis of [ 3764-36-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3764-36-1 ]

[ 3764-36-1 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 3764-36-1 ]
  • [ 7440-44-0 ]
  • [ 7440-05-3 ]
  • 4-(2,2,2-Trifluoroethy)aniline [ No CAS ]
  • [ 131395-17-0 ]
YieldReaction ConditionsOperation in experiment
With hydrazine hydrate; In ethanol; cyclohexane; water; ethyl acetate; 4-(2,2,2-Trifluoroethyl)aniline may be prepared in the following manner: palladinized charcoal (0.17 g) containing 10% of palladium is added to a solution of 4-(2,2,2-trifluoroethyl)nitrobenzene (3.8 g) in ethanol (20 cc), and a solution of hydrazine hydrate (1.8 cc) in ethanol (10 cc) is introduced dropwise and with stirring in the course of 20 minutes; the mixture is then heated to reflux for 15 minutes and the temperature is allowed to return to about 20 C. The catalyst is filtered off, the filtrate is concentrated two-fold under reduced pressure (20 mm Hg; 2.7 kPa), water (30 cc) is added and the mixture is extracted with ethyl acetate (200 cc in total). The organic solution is dried over magnesium sulphate, filtered and evaporated under reduced pressure (20 mm Hg; 2.7 kPa), and the evaporation residue (2.7 g) is purified by chromatography on a column of silica with a mixture of cyclohexane and ethyl acetate (70:30 by volume) as eluant. 4-(2,2,2-Trifluoroethy)aniline (2.3 g) is obtained in the form of a yellow oil, which is used directly in the cyclization stage. 4-(2,2,2-Trifluoroethyl)nitrobenzene may be prepared according to the methods described by S. A. FUQUA et al., J. Org. Chem., 30, 1027 (1965), L. M. YAGUPOLSKII et al., Synthesis, (11), 932 (1980), I. KUMADAKI et al., J. Org. Chem., 53, 3637 (1988).
 

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