375368-94-8|tert-Butyl 3-bromo-4-fluorobenzoate| Ambeed

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Quality Control of [ 375368-94-8 ] Purity: 97% SDS Specification

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Product Details of [ 375368-94-8 ]

CAS No. :	375368-94-8
Formula :	C₁₁H₁₂BrFO₂
M.W :	275.11
SMILES Code :	O=C(OC(C)(C)C)C1=CC=C(F)C(Br)=C1
MDL No. :	MFCD03095011
InChI Key :	MUGCZCJMBJFCIX-UHFFFAOYSA-N
Pubchem ID :	44754911

Safety of [ 375368-94-8 ]

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H301-H311-H331
Precautionary Statements:	P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501
Class:	6.1
UN#:	2811
Packing Group:	Ⅲ

Application In Synthesis of [ 375368-94-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 375368-94-8 ]

[ 375368-94-8 ] Synthesis Path-Downstream 1~9

1
[ 1007-16-5 ]
[ 75-65-0 ]
[ 375368-94-8 ]

Yield	Reaction Conditions	Operation in experiment
		Exam ple 1E: Com pound 1OT7Step 1- Add carbonyi diimtcfazoie (3.68 g, 227 mmol) to a mixture of 3-bromo-4-fluoro benzoic acid 1e1 (2.51 g, 115 mmoi) in DMF (25 mL} and stir at RT for about 1 ft. Cool the reaction to CfC and add t-BuOH (5,7 ml, 59,4 mmol). Then add DBU (1.9 mL, 12,8 mmol) dropwise. Allow the mixture to warm to RT and stir for about 21 ft, Dilute the mixture with t-BME and wash successively with 10% titrie acid (aqueous) and saturated NaHCO^ (aqueous). Dry over MgSO4, filter and evaporate the votatiies to obtain 1e2.

References: [1]Patent: WO2010/37210,2010,A1 .Location in patent: Page/Page column 60-61.

2
[ 375368-94-8 ]
C₁₉H₂₇NO₄ [ No CAS ]
C₃₀H₃₈BrNO₆ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With caesium carbonate; In dimethyl sulfoxide; at 50℃; for 18.0h;	Step 2: Add anhydrous cesium carbonate (387 mg, 1,13 mmol) to a mixture of 1e2 (310 mg, 1.13 mmol) and 1c2 (255 mg, 0,76 mmol) tn DMSO (4 mL) and stir at S0C for about 18 h. Dilute the mixture t-BME and wash successively with 10% cine acid (aqueous) and saturated NaHCGj (aqueous). Dry over MgSO4, filter and evaporate Ihe volatiles. Purification by flash chromatography (EtOAc/Hexanes) provides 1e3,

References: [1]Patent: WO2010/37210,2010,A1 .Location in patent: Page/Page column 61.

3
[ 375368-94-8 ]
C₂₅H₂₇NO₆ [ No CAS ]